| Field | Description |
|---|---|
| SampleID | Name of the sample |
| TrimReads | Total number of reads after quality filtering |
| MeanReadLen | Average read length after quality filtering |
| Contigs | Number of contigs of the draft genome (>200bp) |
| GenomeLength | Length (bp) of the draft genome |
| LargestContig | Length (bp) of the largest contig in the genome |
| N50 | Length of the smallest contig in the set that contains the fewest (largest) contigs whose combined length represents at least 50% of the assembly |
| GC-Content | GC content (%) of the draft genome |
| Depth | Number of times each nucleotide position in the draft genome has a read that aligns to that position |
| SampleID | TrimReads | MeanReadLen | Contigs | GenomeLength | LargestContig | N50 | GC-Content | Depth |
|---|---|---|---|---|---|---|---|---|
| Catt-BWE_048B | 230174 | 169 | 2240 | 3715684 | 11806 | 2090 | 51.49 | 10X |
| Catt-BWE_054A | 304450 | 155 | 2462 | 4118917 | 17419 | 2172 | 50.94 | 11X |
| Catt-BWE_113B | 311660 | 162 | 2273 | 4247867 | 27842 | 2521 | 50.76 | 11X |
| Catt-HIM_031B | 164526 | 165 | 2995 | 2563559 | 4310 | 913 | 50.70 | 10X |
| Catt-HIM_045B | 329330 | 143 | 3224 | 3520313 | 13526 | 1258 | 50.51 | 13X |
| Catt-HIM_048B | 291558 | 161 | 2114 | 3903224 | 16987 | 2403 | 51.43 | 12X |
| Catt-HIM_068A | 242972 | 164 | 2748 | 3796931 | 12856 | 1680 | 51.55 | 10X |
| Catt-HIM_073A | 227696 | 158 | 3054 | 3346460 | 6620 | 1272 | 51.13 | 10X |
| Catt-HIM_082A1 | 298778 | 163 | 2396 | 4267109 | 13284 | 2407 | 51.11 | 11X |
| Catt-KAT_009_A1 | 344352 | 168 | 1344 | 4475396 | 26936 | 5163 | 50.85 | 12X |
| Catt-KAT_013A1 | 239918 | 167 | 3023 | 3487810 | 10159 | 1366 | 51.75 | 11X |
| Catt-KAT_036B | 90360 | 167 | 1226 | 777772 | 4764 | 620 | 50.33 | 19X |
| Home-BWE_054A | 341966 | 163 | 1789 | 4542485 | 21516 | 3592 | 51.11 | 12X |
| Home-HIM_031A | 261270 | 164 | 2060 | 4024124 | 18944 | 2607 | 50.99 | 10X |
| Home-HIM_032A | 218272 | 168 | 2605 | 3838236 | 9168 | 1832 | 50.87 | 9X |
| Home-HIM_045A | 479548 | 142 | 1520 | 4254672 | 24612 | 4234 | 50.87 | 16X |
| Home-HIM_047B | 258442 | 169 | 1967 | 4263045 | 15928 | 3108 | 55.96 | 10X |
| Home-HIM_048A | 318010 | 165 | 1299 | 4336772 | 27117 | 4994 | 50.96 | 12X |
| Home-HIM_068B | 250506 | 161 | 2738 | 3788525 | 9060 | 1681 | 50.94 | 10X |
| Home-HIM_071A | 264128 | 161 | 2522 | 4010382 | 13352 | 2100 | 51.08 | 10X |
| Home-HIM_072A | 229122 | 170 | 2430 | 3863330 | 13217 | 1999 | 51.41 | 10X |
| Home-HIM_073B | 274600 | 165 | 3133 | 3997463 | 12594 | 1533 | 50.78 | 11X |
| Home-HIM_075A | 433206 | 167 | 790 | 4565722 | 45205 | 9881 | 50.98 | 15X |
| Home-HIM_82A | 275378 | 172 | 1845 | 4425285 | 24299 | 3473 | 51.08 | 10X |
| Home-KAT_009A | 337726 | 163 | 2433 | 4437467 | 14004 | 2489 | 50.88 | 12X |
| Home-KAT_013A | 228108 | 170 | 2879 | 3740660 | 12726 | 1592 | 51.14 | 10X |
| Home-KAT_023A | 321126 | 158 | 2630 | 4020724 | 14588 | 1950 | 51.32 | 12X |
| Home-KAT_039B | 168914 | 164 | 2928 | 2793862 | 25204 | 1032 | 50.24 | 9X |
| Hosp-BWE_048 | 182824 | 169 | 3078 | 3302835 | 8241 | 1225 | 51.05 | 9X |
| Hosp-BWE_054 | 425850 | 157 | 1484 | 4757167 | 21565 | 4755 | 50.80 | 14X |
| Hosp-BWE_076 | 214110 | 161 | 3008 | 3192002 | 7609 | 1205 | 50.81 | 10X |
| Hosp-BWE_106 | 171380 | 166 | 3159 | 2890869 | 8594 | 1005 | 50.82 | 9X |
| Hosp-HIM_031 | 207346 | 163 | 2912 | 3577483 | 9055 | 1470 | 50.70 | 9X |
| Hosp-HIM_045 | 387642 | 150 | 1866 | 4158817 | 12843 | 3117 | 51.01 | 13X |
| Hosp-HIM_048 | 330554 | 156 | 2939 | 4079520 | 19766 | 1687 | 50.22 | 12X |
| Hosp-HIM_068 | 398734 | 169 | 833 | 4556867 | 40148 | 8964 | 50.71 | 14X |
| Hosp-HIM_071A | 327566 | 159 | 2917 | 4249416 | 12074 | 1830 | 51.03 | 12X |
| Hosp-HIM_82 | 214874 | 170 | 2860 | 3736242 | 9583 | 1563 | 50.97 | 9X |
| Hosp-KAT_009 | 289630 | 155 | 2779 | 3956709 | 10531 | 1789 | 50.83 | 11X |
| Hosp-KAT_013 | 233622 | 169 | 2759 | 3728264 | 9258 | 1688 | 51.03 | 10X |
| Hosp-KAT_023 | 293682 | 164 | 2931 | 4145128 | 10214 | 1759 | 51.09 | 11X |
| Hosp-KAT_039 | 260886 | 164 | 2375 | 4130433 | 18456 | 2290 | 50.99 | 10X |
## Warning: `arrange_()` is deprecated as of dplyr 0.7.0.
## Please use `arrange()` instead.
## See vignette('programming') for more help
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_warnings()` to see where this warning was generated.
Average number of reads per sample = 277971
| Field | Description |
|---|---|
| Contig | Contig name where the gene was found |
| Start | Start position of the gene within the contig |
| End | End position of the gene within the contig |
| Gene | Antibiotic resistance gene |
| Gaps | Gaps in subject (genome) and query (antibiotic resistance gene) |
| Coverage | Proportion (%) of the gene covered |
| Identity | Proportion (%) of exact nucleotide matches |
| Accession | Accesion number of the antibiotic resistance gene |
| Product | Antibiotic resistance gene product |
| Resistance | Antibiotic that the gene confers resistance to |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00153 | 739 | 1542 | aph(3’’)-Ib_5 | 0/0 | 100 | 100.0 | AF321551 | aph(3’’)-Ib | Streptomycin |
| contig01204 | 109 | 969 | blaTEM-1B_1 | 0/0 | 100 | 100.0 | AY458016 | blaTEM-1B | Amoxicillin, Ampicillin, Cephalothin, Piperacillin, Ticarcillin |
| contig01222 | 42 | 551 | dfrA8_1 | 0/0 | 100 | 100.0 | U10186 | dfrA8 | Trimethoprim |
| contig00153 | 1603 | 2418 | sul2_2 | 0/0 | 100 | 100.0 | AY034138 | sul2 | Sulfamethoxazole |
| contig00594 | 740 | 1945 | tet(B)_2 | 0/0 | 100 | 99.9 | AF326777 | tet(B) | Doxycycline, Tetracycline, Minocycline |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00933 | 197 | 1354 | acrE | 0/0 | 100.0 | 98.8 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00153 | 739 | 1542 | APH(3’’)-Ib | 0/0 | 100.0 | 99.8 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig01074 | 92 | 911 | bacA | 0/0 | 99.8 | 98.5 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00996 | 681 | 1372 | baeR | 0/0 | 95.7 | 99.3 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00003 | 7704 | 9074 | cpxA | 0/0 | 99.8 | 98.8 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00490 | 620 | 1252 | CRP | 0/0 | 100.0 | 99.5 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig01222 | 42 | 551 | dfrA8 | 0/0 | 100.0 | 100.0 | KJ174469:710-1220 | dfrA8 is a transposon-encoded dihydrofolate reductase found in Salmonella enterica | diaminopyrimidine |
| contig01021 | 105 | 1277 | emrA | 0/0 | 100.0 | 98.3 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig00659 | 705 | 1037 | Escherichia_coli_emrE | 0/0 | 100.0 | 92.5 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig00810 | 81 | 494 | H-NS | 0/0 | 100.0 | 99.3 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00160 | 27 | 410 | marA | 0/0 | 100.0 | 99.5 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00186 | 1236 | 2393 | mdtE | 0/0 | 100.0 | 99.6 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00503 | 331 | 1557 | mdtG | 0/0 | 100.0 | 99.3 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00134 | 1897 | 3129 | mdtM | 0/0 | 100.0 | 95.0 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00534 | 359 | 1390 | mdtN | 0/0 | 100.0 | 98.2 | AP009048.1:4307588-4306556 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride. | acridine_dye, nucleoside |
| contig00698 | 54 | 1520 | mdtP | 0/0 | 100.0 | 98.2 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00310 | 945 | 1421 | mphB | 0/0 | 100.0 | 98.1 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig01265 | 217 | 1139 | pmrF | 0/0 | 95.2 | 99.3 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00153 | 1603 | 2418 | sul2 | 0/0 | 100.0 | 100.0 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig01204 | 109 | 969 | TEM-1 | 0/0 | 100.0 | 99.9 | AL513383:161910-162771 | TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. | cephalosporin, monobactam, penam, penem |
| contig00594 | 740 | 1945 | tet(B) | 0/0 | 100.0 | 99.7 | AB089595:0-1206 | Tet(B) is a tetracycline efflux protein expressed in many Gram-negative bacteria. It confers resistance to tetracycline doxycycline and minocycline but not tigecycline. | tetracycline |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00153 | 739 | 1542 | (AGly)strA | 0/0 | 100 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig01204 | 109 | 969 | (Bla)blaTEM-105 | 0/0 | 100 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00153 | 1603 | 2418 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00594 | 740 | 1945 | (Tet)tetB | 0/0 | 100 | 99.6 | AB089594:1-1206 | (Tet)tetB | NA |
| contig01222 | 42 | 551 | (Tmt)dfrA8 | 0/0 | 100 | 100.0 | U10186:711-1220 | (Tmt)dfrA8 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00153 | 739 | 1542 | (AGly)strA | 0/0 | 100 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig01204 | 109 | 969 | (Bla)blaTEM-105 | 0/0 | 100 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00153 | 1603 | 2418 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00594 | 740 | 1945 | (Tet)tetB | 0/0 | 100 | 99.6 | AB089594:1-1206 | (Tet)tetB | NA |
| contig01222 | 42 | 551 | (Tmt)dfrA8 | 0/0 | 100 | 100.0 | U10186:711-1220 | (Tmt)dfrA8 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00933 | 197 | 1354 | ACRE | 0/0 | 100.0 | 98.8 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig00153 | 739 | 1566 | APH3-DPRIME | 0/0 | 100.0 | 100.0 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig01074 | 92 | 911 | BACA | 0/0 | 99.8 | 98.8 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00996 | 681 | 1372 | BAER | 0/0 | 95.7 | 99.3 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00003 | 7009 | 7707 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2122 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00003 | 7704 | 9074 | CPXAR | 0/0 | 99.8 | 99.5 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00490 | 620 | 1252 | CRP | 0/0 | 100.0 | 99.5 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig01222 | 42 | 551 | DFRA | 0/0 | 100.0 | 100.0 | MEG_2553 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig01021 | 105 | 1277 | EMRA | 0/0 | 100.0 | 98.3 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig00810 | 81 | 494 | HNS | 0/0 | 100.0 | 99.3 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00160 | 27 | 416 | MARA | 0/0 | 100.0 | 99.5 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00160 | 430 | 864 | MARR | 0/0 | 100.0 | 98.2 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00186 | 1236 | 2393 | MDTE | 0/0 | 100.0 | 99.6 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00503 | 331 | 1557 | MDTG | 0/0 | 100.0 | 99.5 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00134 | 1897 | 3129 | MDTM | 0/0 | 100.0 | 95.0 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00534 | 359 | 1390 | MDTN | 0/0 | 100.0 | 98.2 | MEG_3763 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTN | NA |
| contig00698 | 54 | 1520 | MDTP | 0/0 | 100.0 | 98.2 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00310 | 945 | 1421 | MPHB | 0/0 | 100.0 | 98.1 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00659 | 705 | 1037 | MVRC | 0/0 | 100.0 | 92.5 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig01265 | 217 | 1139 | PMRF | 0/0 | 95.2 | 99.3 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00025 | 230 | 1099 | ROBA | 0/0 | 100.0 | 99.2 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00734 | 1383 | 1706 | SOXS | 0/0 | 100.0 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00153 | 1603 | 2418 | SULII | 0/0 | 100.0 | 100.0 | MEG_6617 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| contig00594 | 740 | 1945 | TETB | 0/0 | 100.0 | 99.9 | MEG_7052 | Drugs:Tetracyclines:Tetracycline_resistance_MFS_efflux_pumps:TETB | NA |
## [1] "No antibiotic resitance genes from Resfinder database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00329 | 1 | 2891 | acrB | 0/0 | 91.8 | 99.0 | U00096.3:484403-481253 | Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00676 | 1136 | 1798 | acrS | 0/0 | 100.0 | 97.4 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00955 | 1 | 805 | bacA | 0/0 | 97.9 | 96.8 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00107 | 3712 | 4433 | baeR | 0/0 | 99.9 | 98.2 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00107 | 2312 | 3715 | baeS | 0/0 | 100.0 | 97.6 | AP009048:2165012-2166416 | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance. | aminocoumarin, aminoglycoside |
| contig00069 | 3582 | 4955 | cpxA | 0/0 | 100.0 | 98.2 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00179 | 2848 | 3480 | CRP | 0/0 | 100.0 | 99.7 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00099 | 2017 | 3072 | emrK | 0/0 | 100.0 | 98.0 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig01097 | 478 | 1008 | emrR | 0/0 | 100.0 | 99.4 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00099 | 479 | 2017 | emrY | 0/0 | 100.0 | 97.6 | D78168:1591-3130 | emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. | tetracycline |
| contig00038 | 447 | 2090 | eptA | 0/0 | 100.0 | 98.0 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00152 | 2583 | 3776 | Escherichia_coli_acrA | 0/0 | 100.0 | 98.9 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00087 | 942 | 2075 | Escherichia_coli_ampC | 0/0 | 100.0 | 96.9 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00557 | 850 | 1182 | Escherichia_coli_emrE | 0/0 | 100.0 | 92.2 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig00099 | 3596 | 4210 | evgA | 0/0 | 100.0 | 99.2 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00103 | 1549 | 2277 | gadW | 0/0 | 100.0 | 95.5 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00103 | 356 | 1180 | gadX | 0/0 | 100.0 | 96.8 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00287 | 666 | 1079 | H-NS | 0/0 | 100.0 | 99.3 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00278 | 1003 | 1386 | marA | 0/0 | 100.0 | 99.7 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00251 | 1077 | 2231 | mdtE | 1/3 | 99.7 | 98.3 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00371 | 343 | 1374 | mdtN | 0/0 | 100.0 | 97.0 | AP009048.1:4307588-4306556 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride. | acridine_dye, nucleoside |
| contig00170 | 2048 | 3016 | pmrF | 0/0 | 100.0 | 98.3 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00087 | 942 | 2075 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 96.9 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00315 | 839 | 2740 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 98.7 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00087 | 942 | 2075 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 96.9 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00315 | 839 | 2740 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 98.7 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00152 | 2583 | 3776 | ACRA | 0/0 | 100.0 | 98.9 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00329 | 1 | 2891 | ACRB | 0/0 | 91.8 | 99.0 | MEG_401 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRB | NA |
| contig00676 | 1136 | 1798 | ACRS | 0/0 | 100.0 | 97.4 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00955 | 1 | 805 | BACA | 0/0 | 97.9 | 97.0 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00107 | 3712 | 4433 | BAER | 0/0 | 99.9 | 98.2 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00107 | 2312 | 3715 | BAES | 0/0 | 100.0 | 97.6 | MEG_1193 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAES | NA |
| contig00087 | 942 | 2075 | BLAEC | 0/0 | 100.0 | 97.5 | MEG_1282 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00069 | 2887 | 3585 | CPXAR | 0/0 | 100.0 | 99.3 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00069 | 3582 | 4955 | CPXAR | 0/0 | 100.0 | 98.2 | MEG_2119 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00179 | 2848 | 3480 | CRP | 0/0 | 100.0 | 99.7 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00021 | 4410 | 5600 | EMRD | 0/0 | 100.0 | 98.1 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00099 | 2017 | 3180 | EMRK | 0/0 | 100.0 | 98.2 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig01097 | 478 | 1008 | EMRR | 0/0 | 100.0 | 99.4 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00099 | 479 | 2017 | EMRY | 0/0 | 100.0 | 97.7 | MEG_2736 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRY | NA |
| contig00038 | 447 | 2090 | EPTA | 0/0 | 100.0 | 98.0 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00103 | 1549 | 2277 | GADW | 0/0 | 100.0 | 97.4 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00103 | 356 | 1180 | GADX | 0/0 | 100.0 | 96.8 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00287 | 666 | 1079 | HNS | 0/0 | 100.0 | 99.3 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00278 | 997 | 1386 | MARA | 0/0 | 100.0 | 99.7 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00278 | 548 | 982 | MARR | 0/0 | 100.0 | 97.9 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00251 | 1077 | 2231 | MDTE | 1/3 | 99.7 | 98.3 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00995 | 730 | 1059 | MDTI | 0/0 | 100.0 | 98.5 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00995 | 378 | 743 | MDTJ | 0/0 | 100.0 | 98.6 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00371 | 343 | 1374 | MDTN | 0/0 | 100.0 | 97.0 | MEG_3763 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTN | NA |
| contig00557 | 850 | 1182 | MVRC | 0/0 | 100.0 | 92.2 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig00315 | 839 | 2740 | PBP2 | 0/0 | 100.0 | 98.7 | MEG_5400 | Drugs:betalactams:Penicillin_binding_protein:PBP2 | NA |
| contig00170 | 2048 | 3016 | PMRF | 0/0 | 100.0 | 98.3 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00841 | 699 | 1568 | ROBA | 0/0 | 100.0 | 99.3 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
## [1] "No antibiotic resitance genes from Resfinder database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00321 | 175 | 3159 | acrF | 0/0 | 96.1 | 99.0 | U00096:3415032-3418137 | AcrF is a inner membrane transporter similar to AcrB. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00254 | 2788 | 3450 | acrS | 0/0 | 100.0 | 99.4 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00783 | 1026 | 1845 | bacA | 0/0 | 99.8 | 98.8 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00521 | 1687 | 2319 | CRP | 0/0 | 100.0 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00290 | 843 | 2381 | emrB | 0/0 | 100.0 | 98.5 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig01013 | 320 | 1375 | emrK | 0/0 | 100.0 | 98.4 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00537 | 300 | 830 | emrR | 0/0 | 100.0 | 99.8 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00035 | 4331 | 5524 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.8 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00052 | 1444 | 2748 | Escherichia_coli_ampC1_beta-lactamase | 0/0 | 100.0 | 98.2 | FN649414.1:2765050-2766355 | An ampC-like beta-lactamase identified from Escherichia coli. | cephalosporin, penam |
| contig01428 | 296 | 910 | evgA | 0/0 | 100.0 | 99.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00013 | 1225 | 1953 | gadW | 0/0 | 100.0 | 94.4 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00013 | 33 | 857 | gadX | 0/0 | 100.0 | 97.9 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00470 | 878 | 1291 | H-NS | 0/0 | 100.0 | 99.3 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00280 | 2502 | 2885 | marA | 0/0 | 100.0 | 99.5 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00125 | 3296 | 4543 | mdtA | 0/0 | 100.0 | 98.2 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00125 | 174 | 3296 | mdtB | 0/0 | 100.0 | 98.4 | U00096:2155262-2158385 | MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. | aminocoumarin |
| contig00013 | 5454 | 6611 | mdtE | 0/0 | 100.0 | 99.7 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00013 | 2316 | 5429 | mdtF | 0/0 | 100.0 | 98.5 | U00096:3660413-3663527 | MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex. | fluoroquinolone, macrolide, penam |
| contig00374 | 972 | 2198 | mdtG | 0/0 | 100.0 | 99.3 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00383 | 1246 | 2478 | mdtM | 0/0 | 100.0 | 96.0 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00171 | 1319 | 1793 | mphB | 0/0 | 99.6 | 97.5 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00466 | 1479 | 2645 | ugd | 0/0 | 100.0 | 97.0 | U00096:2099613-2098446 | PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin | peptide |
| contig00522 | 795 | 2438 | yojI | 0/0 | 100.0 | 98.0 | U00096.3:2308615-2306971 | YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00052 | 1444 | 2748 | (Bla)AmpC1_Ecoli | 0/0 | 100.0 | 98.2 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00698 | 249 | 2058 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 95.2 | 98.7 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
## [1] "No antibiotic resitance genes from NCBI database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00035 | 4331 | 5524 | ACRA | 0/0 | 100.0 | 99.8 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00321 | 175 | 3159 | ACRF | 0/0 | 96.1 | 99.0 | MEG_409 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRF | NA |
| contig00254 | 2788 | 3450 | ACRS | 0/0 | 100.0 | 99.4 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00222 | 1927 | 3779 | ASMA | 0/0 | 100.0 | 98.6 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00783 | 1026 | 1845 | BACA | 0/0 | 99.8 | 98.8 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00061 | 3007 | 4197 | BCR | 0/0 | 100.0 | 98.1 | MEG_1210 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig01188 | 224 | 922 | CPXAR | 0/0 | 100.0 | 99.4 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00521 | 1687 | 2319 | CRP | 0/0 | 100.0 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00290 | 843 | 2381 | EMRB | 0/0 | 100.0 | 98.5 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig01013 | 320 | 1483 | EMRK | 0/0 | 100.0 | 98.5 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00537 | 300 | 830 | EMRR | 0/0 | 100.0 | 99.8 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00013 | 1225 | 1953 | GADW | 0/0 | 100.0 | 98.6 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00013 | 33 | 857 | GADX | 0/0 | 100.0 | 97.9 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00470 | 878 | 1291 | HNS | 0/0 | 100.0 | 99.3 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00280 | 2496 | 2885 | MARA | 0/0 | 100.0 | 99.5 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00280 | 2048 | 2482 | MARR | 0/0 | 100.0 | 97.7 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00125 | 3296 | 4543 | MDTA | 0/0 | 100.0 | 98.2 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00125 | 174 | 3296 | MDTB | 0/0 | 100.0 | 98.4 | MEG_3747 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTB | NA |
| contig00013 | 5454 | 6611 | MDTE | 0/0 | 100.0 | 99.7 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00013 | 2316 | 5429 | MDTF | 0/0 | 100.0 | 98.5 | MEG_3752 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTF | NA |
| contig00374 | 972 | 2198 | MDTG | 0/0 | 100.0 | 99.4 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00405 | 1992 | 2321 | MDTI | 0/0 | 100.0 | 99.4 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00405 | 2308 | 2673 | MDTJ | 0/0 | 100.0 | 99.7 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00461 | 701 | 2074 | MDTK | 0/0 | 100.0 | 99.0 | MEG_3759 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MATE_efflux_pumps:MDTK | NA |
| contig00383 | 1246 | 2478 | MDTM | 0/0 | 100.0 | 96.0 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00171 | 1319 | 1793 | MPHB | 0/0 | 99.6 | 97.5 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00698 | 249 | 2058 | PBP2 | 0/0 | 95.2 | 98.7 | MEG_5400 | Drugs:betalactams:Penicillin_binding_protein:PBP2 | NA |
| contig00052 | 1444 | 2748 | PBP4B | 0/0 | 100.0 | 98.2 | MEG_5409 | Drugs:betalactams:Penicillin_binding_protein:PBP4B | NA |
| contig00928 | 454 | 1323 | ROBA | 0/0 | 100.0 | 99.4 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00466 | 1479 | 2645 | UGD | 0/0 | 100.0 | 97.0 | MEG_7328 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:UGD | NA |
| contig00522 | 795 | 2438 | YOGI | 0/0 | 100.0 | 98.0 | MEG_7842 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_ABC_efflux_pumps:YOGI | NA |
## [1] "No antibiotic resitance genes from Resfinder database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00117 | 199 | 1371 | emrA | 0/0 | 100 | 97.9 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig01192 | 8 | 622 | evgA | 0/0 | 100 | 99.2 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
## [1] "No antibiotic resitance genes from ARG-ANNOT database were found"
## [1] "No antibiotic resitance genes from NCBI database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00533 | 363 | 1061 | CPXAR | 0/0 | 100.0 | 99.4 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00117 | 199 | 1371 | EMRA | 0/0 | 100.0 | 97.9 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig01276 | 412 | 759 | QACEDELTA1 | 0/0 | 100.0 | 100.0 | MEG_5829 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:QACEDELTA1 | NA |
| contig00477 | 420 | 1206 | ROBA | 0/0 | 90.5 | 99.5 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00351 | 679 | 1884 | tet(B)_1 | 0/0 | 100 | 100 | AP000342 | tet(B) | Doxycycline, Tetracycline, Minocycline |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00159 | 5 | 1060 | emrK | 0/0 | 100.0 | 99.7 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00236 | 126 | 1769 | eptA | 0/0 | 100.0 | 99.5 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00622 | 1 | 1074 | Escherichia_coli_ampC | 0/0 | 94.7 | 97.4 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig02078 | 103 | 435 | Escherichia_coli_emrE | 0/0 | 100.0 | 97.6 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig00159 | 1584 | 2198 | evgA | 0/0 | 100.0 | 99.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00021 | 1423 | 2151 | gadW | 0/0 | 100.0 | 94.4 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00021 | 231 | 1055 | gadX | 0/0 | 100.0 | 97.9 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00172 | 567 | 1793 | mdtG | 0/0 | 100.0 | 99.3 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig01539 | 368 | 844 | mphB | 0/0 | 100.0 | 98.1 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00711 | 125 | 1093 | pmrF | 0/0 | 100.0 | 99.4 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00351 | 679 | 1884 | tet(B) | 0/0 | 100.0 | 99.8 | AB089595:0-1206 | Tet(B) is a tetracycline efflux protein expressed in many Gram-negative bacteria. It confers resistance to tetracycline doxycycline and minocycline but not tigecycline. | tetracycline |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00622 | 1 | 1074 | (Bla)AmpC2_Ecoli | 0/0 | 94.7 | 97.4 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00351 | 679 | 1884 | (Tet)tetB | 0/0 | 100.0 | 99.8 | AB089594:1-1206 | (Tet)tetB | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00622 | 1 | 1074 | (Bla)AmpC2_Ecoli | 0/0 | 94.7 | 97.4 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00351 | 679 | 1884 | (Tet)tetB | 0/0 | 100.0 | 99.8 | AB089594:1-1206 | (Tet)tetB | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00622 | 1 | 1074 | BLAEC | 0/0 | 94.7 | 99.9 | MEG_1280 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig01032 | 1 | 670 | CPXAR | 0/0 | 95.8 | 99.4 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00560 | 198 | 1388 | EMRD | 0/0 | 100.0 | 99.8 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00159 | 5 | 1168 | EMRK | 0/0 | 100.0 | 99.7 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00236 | 126 | 1769 | EPTA | 0/0 | 100.0 | 99.5 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00021 | 1423 | 2151 | GADW | 0/0 | 100.0 | 98.6 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00021 | 231 | 1055 | GADX | 0/0 | 100.0 | 97.9 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig01348 | 386 | 820 | MARR | 0/0 | 100.0 | 98.2 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00172 | 567 | 1793 | MDTG | 0/0 | 100.0 | 99.4 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig01539 | 368 | 844 | MPHB | 0/0 | 100.0 | 98.1 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig02078 | 103 | 435 | MVRC | 0/0 | 100.0 | 97.6 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig00711 | 125 | 1093 | PMRF | 0/0 | 100.0 | 99.4 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00111 | 522 | 845 | SOXS | 0/0 | 100.0 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00351 | 679 | 1884 | TETB | 0/0 | 100.0 | 100.0 | MEG_7042 | Drugs:Tetracyclines:Tetracycline_resistance_MFS_efflux_pumps:TETB | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00971 | 1 | 1180 | mdf(A)_1 | 0/0 | 95.7 | 99.9 | Y08743 | mdf(A) | |
| contig00899 | 23 | 679 | qnrS1_1 | 0/0 | 100.0 | 100.0 | AB187515 | qnrS1 | Ciprofloxacin |
| contig00452 | 372 | 1187 | sul2_2 | 0/0 | 100.0 | 100.0 | AY034138 | sul2 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00196 | 509 | 3613 | acrF | 0/0 | 100.0 | 99.5 | U00096:3415032-3418137 | AcrF is a inner membrane transporter similar to AcrB. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig01301 | 227 | 1048 | bacA | 0/0 | 100.0 | 100.0 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00682 | 477 | 1199 | baeR | 0/0 | 100.0 | 99.9 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00123 | 3055 | 4428 | cpxA | 0/0 | 100.0 | 99.0 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00129 | 1004 | 1636 | CRP | 0/0 | 100.0 | 99.4 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00139 | 2800 | 3855 | emrK | 0/0 | 100.0 | 99.9 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig01931 | 52 | 582 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00139 | 1262 | 2800 | emrY | 0/0 | 100.0 | 99.0 | D78168:1591-3130 | emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. | tetracycline |
| contig00192 | 103 | 1746 | eptA | 0/0 | 100.0 | 100.0 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00198 | 1147 | 2340 | Escherichia_coli_acrA | 0/0 | 100.0 | 100.0 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00021 | 3558 | 4691 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.3 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00971 | 2 | 1180 | Escherichia_coli_mdfA | 0/0 | 95.6 | 98.4 | JQ394987:0-1233 | Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter. | benzalkonium_chloride, rhodamine, tetracycline |
| contig01673 | 1 | 577 | evgA | 0/0 | 93.8 | 100.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig01290 | 1 | 817 | gadX | 0/0 | 99.0 | 100.0 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00029 | 1150 | 1563 | H-NS | 0/0 | 100.0 | 99.5 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig01291 | 568 | 951 | marA | 0/0 | 100.0 | 99.7 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00532 | 138 | 1385 | mdtA | 0/0 | 100.0 | 97.4 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00257 | 1306 | 2514 | mdtH | 0/0 | 100.0 | 99.9 | U00096:1125326-1124117 | Multidrug resistance protein MdtH | fluoroquinolone |
| contig00747 | 305 | 1771 | mdtP | 0/0 | 100.0 | 100.0 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00422 | 1644 | 2118 | mphB | 0/0 | 99.6 | 97.3 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00330 | 836 | 1804 | pmrF | 0/0 | 100.0 | 100.0 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00899 | 23 | 679 | QnrS1 | 0/0 | 100.0 | 100.0 | DQ485529.1:0-657 | QnrS1 is a plasmid-mediated quinolone resistance protein found in Shigella flexneri | fluoroquinolone |
| contig00452 | 372 | 1187 | sul2 | 0/0 | 100.0 | 100.0 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig00748 | 383 | 1850 | tolC | 0/0 | 98.7 | 99.7 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00021 | 3558 | 4691 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.3 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00100 | 592 | 2493 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 100.0 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00899 | 23 | 679 | (Flq)qnr-S1 | 0/0 | 100 | 100.0 | AB187515:9737-10393 | (Flq)qnr-S1 | NA |
| contig00452 | 372 | 1187 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00021 | 3558 | 4691 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.3 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00100 | 592 | 2493 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 100.0 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00899 | 23 | 679 | (Flq)qnr-S1 | 0/0 | 100 | 100.0 | AB187515:9737-10393 | (Flq)qnr-S1 | NA |
| contig00452 | 372 | 1187 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00198 | 1147 | 2340 | ACRA | 0/0 | 100.0 | 100.0 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00196 | 509 | 3613 | ACRF | 0/0 | 100.0 | 99.5 | MEG_409 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRF | NA |
| contig00496 | 542 | 2394 | ASMA | 0/0 | 100.0 | 98.2 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig01301 | 227 | 1048 | BACA | 0/0 | 100.0 | 100.0 | MEG_1190 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00682 | 477 | 1199 | BAER | 0/0 | 100.0 | 99.9 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00133 | 56 | 1246 | BCR | 0/0 | 100.0 | 100.0 | MEG_1210 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig00021 | 3558 | 4691 | BLAEC | 0/0 | 100.0 | 98.6 | MEG_1282 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00123 | 2360 | 3058 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2122 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00123 | 3055 | 4428 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00129 | 1004 | 1636 | CRP | 0/0 | 100.0 | 99.4 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00429 | 1513 | 2593 | EMRD | 0/0 | 90.8 | 100.0 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00139 | 2800 | 3963 | EMRK | 0/0 | 100.0 | 99.9 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig01931 | 52 | 582 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00139 | 1262 | 2800 | EMRY | 0/0 | 100.0 | 99.0 | MEG_2736 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRY | NA |
| contig00192 | 103 | 1746 | EPTA | 0/0 | 100.0 | 100.0 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig01290 | 1 | 817 | GADX | 0/0 | 99.0 | 100.0 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00029 | 1150 | 1563 | HNS | 0/0 | 100.0 | 99.5 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig01291 | 562 | 951 | MARA | 0/0 | 100.0 | 99.7 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig01291 | 113 | 547 | MARR | 0/0 | 100.0 | 98.4 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00971 | 1 | 1180 | MDFA | 0/0 | 95.7 | 100.0 | MEG_3737 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDFA | NA |
| contig00532 | 138 | 1385 | MDTA | 0/0 | 100.0 | 97.4 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00257 | 1306 | 2514 | MDTH | 0/0 | 100.0 | 99.9 | MEG_3755 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTH | NA |
| contig00747 | 305 | 1771 | MDTP | 0/0 | 100.0 | 100.0 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00422 | 1644 | 2118 | MPHB | 0/0 | 99.6 | 97.3 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00100 | 592 | 2493 | PBP2 | 0/0 | 100.0 | 100.0 | MEG_5400 | Drugs:betalactams:Penicillin_binding_protein:PBP2 | NA |
| contig00330 | 836 | 1804 | PMRF | 0/0 | 100.0 | 100.0 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00899 | 23 | 679 | QNRS | 0/0 | 100.0 | 100.0 | MEG_6020 | Drugs:Fluoroquinolones:Quinolone_resistance_protein_Qnr:QNRS | NA |
| contig01419 | 187 | 977 | ROBA | 0/0 | 90.9 | 99.0 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig01532 | 543 | 865 | SOXS | 0/0 | 99.7 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00452 | 372 | 1187 | SULII | 0/0 | 100.0 | 100.0 | MEG_6617 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
## [1] "No antibiotic resitance genes from Resfinder database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00824 | 739 | 1461 | baeR | 0/0 | 100.0 | 99.5 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00342 | 532 | 1164 | CRP | 0/0 | 100.0 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig01111 | 1 | 1103 | emrA | 0/0 | 94.0 | 98.2 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig01026 | 688 | 1218 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00076 | 110 | 1753 | eptA | 0/0 | 100.0 | 99.2 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00265 | 426 | 1619 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.8 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig01869 | 1 | 555 | evgA | 0/0 | 90.2 | 98.9 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00462 | 252 | 980 | gadW | 0/0 | 100.0 | 94.4 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig01649 | 1 | 824 | gadX | 0/0 | 99.9 | 97.8 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00647 | 1294 | 1707 | H-NS | 0/0 | 100.0 | 99.3 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00627 | 266 | 1423 | mdtE | 0/0 | 100.0 | 99.7 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00301 | 395 | 1426 | mdtN | 0/0 | 100.0 | 98.0 | AP009048.1:4307588-4306556 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride. | acridine_dye, nucleoside |
| contig00176 | 1 | 1397 | mdtP | 0/0 | 95.2 | 98.1 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00018 | 2040 | 3788 | msbA | 0/0 | 100.0 | 99.0 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| contig00012 | 1192 | 2679 | tolC | 0/0 | 100.0 | 98.5 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| contig01151 | 78 | 1211 | ugd | 0/0 | 97.2 | 96.3 | U00096:2099613-2098446 | PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin | peptide |
## [1] "No antibiotic resitance genes from ARG-ANNOT database were found"
## [1] "No antibiotic resitance genes from NCBI database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00265 | 426 | 1619 | ACRA | 0/0 | 100.0 | 99.8 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00202 | 1174 | 2950 | ASMA | 0/0 | 95.8 | 98.1 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00824 | 739 | 1461 | BAER | 0/0 | 100.0 | 99.5 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00342 | 532 | 1164 | CRP | 0/0 | 100.0 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig01111 | 1 | 1103 | EMRA | 0/0 | 94.0 | 98.2 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig01026 | 688 | 1218 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00076 | 110 | 1753 | EPTA | 0/0 | 100.0 | 99.2 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00462 | 252 | 980 | GADW | 0/0 | 100.0 | 98.6 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig01649 | 1 | 824 | GADX | 0/0 | 99.9 | 97.8 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00647 | 1294 | 1707 | HNS | 0/0 | 100.0 | 99.3 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00627 | 266 | 1423 | MDTE | 0/0 | 100.0 | 99.7 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig02220 | 96 | 461 | MDTJ | 0/0 | 100.0 | 99.7 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00301 | 395 | 1426 | MDTN | 0/0 | 100.0 | 98.0 | MEG_3763 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTN | NA |
| contig00176 | 1 | 1397 | MDTP | 0/0 | 95.2 | 98.1 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00018 | 2040 | 3788 | MSBA | 0/0 | 100.0 | 99.0 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
| contig00166 | 1083 | 1952 | ROBA | 0/0 | 100.0 | 99.1 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00313 | 2025 | 2347 | SOXS | 0/0 | 99.7 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig01151 | 78 | 1211 | UGD | 0/0 | 97.2 | 96.3 | MEG_7328 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:UGD | NA |
## [1] "No antibiotic resitance genes from Resfinder database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00691 | 197 | 1354 | acrE | 0/0 | 100.0 | 98.8 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00625 | 1 | 1400 | baeS | 0/0 | 99.7 | 99.9 | AP009048:2165012-2166416 | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance. | aminocoumarin, aminoglycoside |
| contig00034 | 999 | 1631 | CRP | 0/0 | 100.0 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00404 | 758 | 1778 | emrK | 0/0 | 96.7 | 99.7 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00068 | 564 | 1094 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00210 | 168 | 1811 | eptA | 0/0 | 100.0 | 99.4 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00265 | 7 | 1140 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.4 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00328 | 259 | 987 | gadW | 0/0 | 100.0 | 94.4 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig01598 | 1 | 772 | gadX | 0/0 | 93.6 | 97.9 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00646 | 1019 | 1402 | marA | 0/0 | 100.0 | 99.5 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00472 | 1 | 1187 | mdtG | 0/0 | 96.7 | 99.2 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00397 | 1302 | 1776 | mphB | 0/0 | 99.6 | 97.5 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00051 | 960 | 2708 | msbA | 0/0 | 100.0 | 99.0 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| contig00197 | 270 | 1757 | tolC | 0/0 | 100.0 | 98.4 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00265 | 7 | 1140 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.4 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00265 | 7 | 1140 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.4 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00691 | 197 | 1354 | ACRE | 0/0 | 100.0 | 98.8 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig00625 | 1 | 1400 | BAES | 0/0 | 99.7 | 99.9 | MEG_1193 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAES | NA |
| contig00265 | 7 | 1140 | BLAEC | 0/0 | 100.0 | 98.1 | MEG_1279 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00534 | 213 | 911 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2122 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00034 | 999 | 1631 | CRP | 0/0 | 100.0 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00068 | 564 | 1094 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00210 | 168 | 1811 | EPTA | 0/0 | 100.0 | 99.4 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00328 | 259 | 987 | GADW | 0/0 | 100.0 | 98.6 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig01598 | 1 | 772 | GADX | 0/0 | 93.6 | 97.9 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00646 | 1013 | 1402 | MARA | 0/0 | 100.0 | 99.5 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00646 | 565 | 999 | MARR | 0/0 | 100.0 | 97.7 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00472 | 1 | 1187 | MDTG | 0/0 | 96.7 | 99.3 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig01908 | 97 | 462 | MDTJ | 0/0 | 100.0 | 99.7 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00397 | 1302 | 1776 | MPHB | 0/0 | 99.6 | 97.5 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00051 | 960 | 2708 | MSBA | 0/0 | 100.0 | 99.0 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
## [1] "No antibiotic resitance genes from Resfinder database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00056 | 5239 | 5901 | acrS | 0/0 | 100.0 | 98.6 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00158 | 84 | 806 | baeR | 0/0 | 100.0 | 99.5 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00158 | 803 | 2206 | baeS | 0/0 | 100.0 | 98.9 | AP009048:2165012-2166416 | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance. | aminocoumarin, aminoglycoside |
| contig00053 | 2156 | 2788 | CRP | 0/0 | 100.0 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00529 | 4 | 1176 | emrA | 0/0 | 100.0 | 98.3 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig00755 | 672 | 1727 | emrK | 0/0 | 100.0 | 98.7 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00855 | 397 | 1590 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.8 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00007 | 8147 | 9280 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.6 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00407 | 1213 | 2370 | Escherichia_coli_ampH | 0/0 | 100.0 | 98.6 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00991 | 1249 | 1581 | Escherichia_coli_emrE | 0/0 | 100.0 | 99.4 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig01513 | 25 | 639 | evgA | 0/0 | 100.0 | 99.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig01296 | 1 | 823 | gadX | 0/0 | 99.8 | 97.8 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00657 | 62 | 475 | H-NS | 0/0 | 100.0 | 99.3 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00085 | 3515 | 3898 | marA | 0/0 | 100.0 | 99.5 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00324 | 215 | 1462 | mdtA | 0/0 | 100.0 | 98.1 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00125 | 964 | 4077 | mdtF | 0/0 | 100.0 | 98.6 | U00096:3660413-3663527 | MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex. | fluoroquinolone, macrolide, penam |
| contig00184 | 651 | 1877 | mdtG | 0/0 | 100.0 | 99.3 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00364 | 1266 | 2474 | mdtH | 0/0 | 100.0 | 98.3 | U00096:1125326-1124117 | Multidrug resistance protein MdtH | fluoroquinolone |
| contig00357 | 1174 | 2406 | mdtM | 0/0 | 100.0 | 95.9 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00397 | 387 | 1418 | mdtN | 0/0 | 100.0 | 98.0 | AP009048.1:4307588-4306556 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride. | acridine_dye, nucleoside |
| contig00511 | 602 | 2068 | mdtP | 0/0 | 100.0 | 98.2 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00686 | 1 | 964 | pmrF | 0/0 | 99.5 | 99.2 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig01319 | 72 | 1195 | ugd | 0/0 | 96.3 | 96.3 | U00096:2099613-2098446 | PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00007 | 8147 | 9280 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.6 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00407 | 1213 | 2370 | (Bla)ampH_Ecoli | 0/0 | 100 | 98.6 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00007 | 8147 | 9280 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.6 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00407 | 1213 | 2370 | (Bla)ampH_Ecoli | 0/0 | 100 | 98.6 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00855 | 397 | 1590 | ACRA | 0/0 | 100.0 | 99.8 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00056 | 5239 | 5901 | ACRS | 0/0 | 100.0 | 98.6 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00407 | 1213 | 2370 | AMPH | 0/0 | 100.0 | 98.6 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00679 | 273 | 2125 | ASMA | 0/0 | 100.0 | 98.2 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00158 | 84 | 806 | BAER | 0/0 | 100.0 | 99.5 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00158 | 803 | 2206 | BAES | 0/0 | 100.0 | 98.9 | MEG_1193 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAES | NA |
| contig00007 | 8147 | 9280 | BLAEC | 0/0 | 100.0 | 99.3 | MEG_1279 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00053 | 2156 | 2788 | CRP | 0/0 | 100.0 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00529 | 4 | 1176 | EMRA | 0/0 | 100.0 | 98.3 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig00755 | 672 | 1835 | EMRK | 0/0 | 100.0 | 98.8 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig01296 | 1 | 823 | GADX | 0/0 | 99.8 | 97.8 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00657 | 62 | 475 | HNS | 0/0 | 100.0 | 99.3 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00085 | 3509 | 3898 | MARA | 0/0 | 100.0 | 99.5 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00085 | 3061 | 3495 | MARR | 0/0 | 100.0 | 97.7 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00324 | 215 | 1462 | MDTA | 0/0 | 100.0 | 98.1 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00125 | 964 | 4077 | MDTF | 0/0 | 100.0 | 98.6 | MEG_3752 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTF | NA |
| contig00184 | 651 | 1877 | MDTG | 0/0 | 100.0 | 99.5 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00364 | 1266 | 2474 | MDTH | 0/0 | 100.0 | 98.3 | MEG_3755 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTH | NA |
| contig00550 | 497 | 826 | MDTI | 0/0 | 100.0 | 99.4 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00550 | 813 | 1178 | MDTJ | 0/0 | 100.0 | 99.7 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00357 | 1174 | 2406 | MDTM | 0/0 | 100.0 | 95.9 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00397 | 387 | 1418 | MDTN | 0/0 | 100.0 | 98.0 | MEG_3763 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTN | NA |
| contig00511 | 602 | 2068 | MDTP | 0/0 | 100.0 | 98.2 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00991 | 1249 | 1581 | MVRC | 0/0 | 100.0 | 99.4 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig00686 | 1 | 964 | PMRF | 0/0 | 99.5 | 99.2 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00035 | 5429 | 6298 | ROBA | 0/0 | 100.0 | 99.1 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00172 | 2869 | 3191 | SOXS | 0/0 | 99.7 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig01319 | 72 | 1195 | UGD | 0/0 | 96.3 | 96.3 | MEG_7328 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:UGD | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00417 | 1201 | 2004 | aph(3’’)-Ib_5 | 0/0 | 100.0 | 99.9 | AF321551 | aph(3’’)-Ib | Streptomycin |
| contig00417 | 365 | 1201 | aph(6)-Id_1 | 0/0 | 100.0 | 99.9 | M28829 | aph(6)-Id | Streptomycin |
| contig01129 | 1 | 812 | blaOXA-1_1 | 0/0 | 97.7 | 99.9 | HQ170510 | blaOXA-1 | Amoxicillin, Amoxicillin+Clavulanic_acid, Ampicillin, Ampicillin+Clavulanic_acid, Cefepime, Piperacillin, Piperacillin+Tazobactam |
| contig01025 | 17 | 877 | blaTEM-1B_1 | 0/0 | 100.0 | 100.0 | AY458016 | blaTEM-1B | Amoxicillin, Ampicillin, Cephalothin, Piperacillin, Ticarcillin |
| contig01005 | 42 | 551 | dfrA8_1 | 0/0 | 100.0 | 100.0 | U10186 | dfrA8 | Trimethoprim |
| contig00173 | 4671 | 5903 | mdf(A)_1 | 0/0 | 100.0 | 98.9 | Y08743 | mdf(A) | |
| contig00417 | 2065 | 2880 | sul2_2 | 0/0 | 100.0 | 100.0 | AY034138 | sul2 | Sulfamethoxazole |
| contig00557 | 1439 | 2644 | tet(B)_2 | 0/0 | 100.0 | 100.0 | AF326777 | tet(B) | Doxycycline, Tetracycline, Minocycline |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00189 | 3062 | 6211 | acrB | 0/0 | 100.0 | 100.0 | U00096.3:484403-481253 | Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00103 | 6882 | 8039 | acrE | 0/0 | 100.0 | 98.9 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00103 | 3766 | 6870 | acrF | 0/0 | 100.0 | 99.1 | U00096:3415032-3418137 | AcrF is a inner membrane transporter similar to AcrB. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00454 | 2689 | 3351 | acrS | 0/0 | 100.0 | 98.9 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00417 | 1201 | 2004 | APH(3’’)-Ib | 0/0 | 100.0 | 99.6 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig00417 | 365 | 1201 | APH(6)-Id | 0/0 | 100.0 | 99.8 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig00756 | 1082 | 1903 | bacA | 0/0 | 100.0 | 99.0 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00426 | 764 | 1486 | baeR | 0/0 | 100.0 | 100.0 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00658 | 943 | 2316 | cpxA | 0/0 | 100.0 | 98.1 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00436 | 719 | 1351 | CRP | 0/0 | 100.0 | 99.8 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig01005 | 42 | 551 | dfrA8 | 0/0 | 100.0 | 100.0 | KJ174469:710-1220 | dfrA8 is a transposon-encoded dihydrofolate reductase found in Salmonella enterica | diaminopyrimidine |
| contig00206 | 880 | 2418 | emrB | 0/0 | 100.0 | 100.0 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig00008 | 2550 | 3605 | emrK | 0/0 | 100.0 | 99.9 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00847 | 684 | 1214 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00008 | 1012 | 2550 | emrY | 0/0 | 100.0 | 99.0 | D78168:1591-3130 | emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. | tetracycline |
| contig00054 | 2406 | 4049 | eptA | 0/0 | 100.0 | 100.0 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00189 | 1846 | 3039 | Escherichia_coli_acrA | 0/0 | 100.0 | 100.0 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00020 | 9353 | 10486 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.3 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00883 | 144 | 1448 | Escherichia_coli_ampC1_beta-lactamase | 0/0 | 100.0 | 100.0 | FN649414.1:2765050-2766355 | An ampC-like beta-lactamase identified from Escherichia coli. | cephalosporin, penam |
| contig00261 | 1222 | 2379 | Escherichia_coli_ampH | 0/0 | 100.0 | 98.9 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00173 | 4671 | 5903 | Escherichia_coli_mdfA | 0/0 | 100.0 | 97.3 | JQ394987:0-1233 | Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter. | benzalkonium_chloride, rhodamine, tetracycline |
| contig00008 | 4129 | 4743 | evgA | 0/0 | 100.0 | 100.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00008 | 4748 | 8341 | evgS | 0/0 | 100.0 | 99.7 | U00096:2484373-2487967 | EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00317 | 1586 | 2314 | gadW | 0/0 | 100.0 | 94.7 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00317 | 394 | 1218 | gadX | 0/0 | 100.0 | 100.0 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00766 | 215 | 1462 | mdtA | 0/0 | 100.0 | 98.2 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00136 | 2008 | 5085 | mdtC | 0/0 | 100.0 | 97.9 | U00096:2158385-2161463 | MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58. | aminocoumarin |
| contig00325 | 1236 | 2393 | mdtE | 0/0 | 100.0 | 100.0 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00562 | 772 | 1998 | mdtG | 0/0 | 100.0 | 99.4 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00190 | 1 | 1204 | mdtM | 0/0 | 97.7 | 95.6 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00159 | 4593 | 6644 | mdtO | 0/0 | 100.0 | 100.0 | AP009048.1:4306557-4304505 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00159 | 3130 | 4596 | mdtP | 0/0 | 100.0 | 100.0 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00080 | 5870 | 6346 | mphB | 0/0 | 100.0 | 98.3 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig01129 | 1 | 812 | OXA-1 | 0/0 | 97.7 | 99.9 | JN420336.1:2230-1399 | OXA-1 is a beta-lactamase found in E. coli | cephalosporin, penam |
| contig00546 | 668 | 1636 | pmrF | 0/0 | 100.0 | 100.0 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00417 | 2065 | 2880 | sul2 | 0/0 | 100.0 | 100.0 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig01025 | 17 | 877 | TEM-1 | 0/0 | 100.0 | 99.9 | AL513383:161910-162771 | TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. | cephalosporin, monobactam, penam, penem |
| contig00557 | 1439 | 2644 | tet(B) | 0/0 | 100.0 | 99.8 | AB089595:0-1206 | Tet(B) is a tetracycline efflux protein expressed in many Gram-negative bacteria. It confers resistance to tetracycline doxycycline and minocycline but not tigecycline. | tetracycline |
| contig00013 | 12612 | 14099 | tolC | 0/0 | 100.0 | 98.4 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| contig00262 | 1512 | 2678 | ugd | 0/0 | 100.0 | 98.9 | U00096:2099613-2098446 | PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin | peptide |
| contig00550 | 1286 | 2792 | yojI | 0/0 | 91.7 | 98.0 | U00096.3:2308615-2306971 | YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01066 | 112 | 916 | (AGly)aadA1-pm | 0/0 | 96.9 | 99.6 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00417 | 1201 | 2004 | (AGly)strA | 0/0 | 100.0 | 99.8 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00417 | 365 | 1201 | (AGly)strB | 0/0 | 100.0 | 99.9 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00883 | 144 | 1448 | (Bla)AmpC1_Ecoli | 0/0 | 100.0 | 100.0 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00020 | 9353 | 10486 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 97.3 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00261 | 1222 | 2379 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 98.9 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig01129 | 1 | 812 | (Bla)blaOXA-1 | 0/0 | 97.7 | 99.9 | JQ682867:1-831 | (Bla)blaOXA-1 | NA |
| contig01025 | 17 | 877 | (Bla)blaTEM-105 | 0/0 | 100.0 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00307 | 1513 | 3414 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100.0 | 99.7 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00417 | 2065 | 2880 | (Sul)sul2 | 0/0 | 100.0 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00557 | 1439 | 2644 | (Tet)tetB | 0/0 | 100.0 | 99.7 | AB089594:1-1206 | (Tet)tetB | NA |
| contig01005 | 42 | 551 | (Tmt)dfrA8 | 0/0 | 100.0 | 100.0 | U10186:711-1220 | (Tmt)dfrA8 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01066 | 112 | 916 | (AGly)aadA1-pm | 0/0 | 96.9 | 99.6 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00417 | 1201 | 2004 | (AGly)strA | 0/0 | 100.0 | 99.8 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00417 | 365 | 1201 | (AGly)strB | 0/0 | 100.0 | 99.9 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00883 | 144 | 1448 | (Bla)AmpC1_Ecoli | 0/0 | 100.0 | 100.0 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00020 | 9353 | 10486 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 97.3 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00261 | 1222 | 2379 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 98.9 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig01129 | 1 | 812 | (Bla)blaOXA-1 | 0/0 | 97.7 | 99.9 | JQ682867:1-831 | (Bla)blaOXA-1 | NA |
| contig01025 | 17 | 877 | (Bla)blaTEM-105 | 0/0 | 100.0 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00307 | 1513 | 3414 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100.0 | 99.7 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00417 | 2065 | 2880 | (Sul)sul2 | 0/0 | 100.0 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00557 | 1439 | 2644 | (Tet)tetB | 0/0 | 100.0 | 99.7 | AB089594:1-1206 | (Tet)tetB | NA |
| contig01005 | 42 | 551 | (Tmt)dfrA8 | 0/0 | 100.0 | 100.0 | U10186:711-1220 | (Tmt)dfrA8 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00189 | 1846 | 3039 | ACRA | 0/0 | 100.0 | 100.0 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00189 | 3062 | 6211 | ACRB | 0/0 | 100.0 | 100.0 | MEG_401 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRB | NA |
| contig00103 | 6882 | 8039 | ACRE | 0/0 | 100.0 | 98.9 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig00103 | 3766 | 6870 | ACRF | 0/0 | 100.0 | 99.1 | MEG_409 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRF | NA |
| contig00454 | 2689 | 3351 | ACRS | 0/0 | 100.0 | 98.9 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00261 | 1222 | 2379 | AMPH | 0/0 | 100.0 | 98.9 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig01066 | 112 | 916 | ANT3-DPRIME | 0/0 | 96.9 | 99.6 | MEG_915 | Drugs:Aminoglycosides:Aminoglycoside_O-nucleotidyltransferases:ANT3-DPRIME | NA |
| contig00417 | 1201 | 2028 | APH3-DPRIME | 0/0 | 100.0 | 99.9 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00417 | 365 | 1201 | APH6 | 0/0 | 100.0 | 100.0 | MEG_1084 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig00397 | 2008 | 3860 | ASMA | 0/0 | 100.0 | 98.3 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00756 | 1082 | 1903 | BACA | 0/0 | 100.0 | 99.0 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00426 | 764 | 1486 | BAER | 0/0 | 100.0 | 100.0 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00483 | 1197 | 2387 | BCR | 0/0 | 100.0 | 100.0 | MEG_1210 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig00020 | 9353 | 10486 | BLAEC | 0/0 | 100.0 | 98.5 | MEG_1282 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00658 | 248 | 946 | CPXAR | 0/0 | 100.0 | 99.6 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00658 | 943 | 2316 | CPXAR | 0/0 | 100.0 | 98.1 | MEG_2119 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00436 | 719 | 1351 | CRP | 0/0 | 100.0 | 99.8 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig01005 | 42 | 551 | DFRA | 0/0 | 100.0 | 100.0 | MEG_2553 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00206 | 880 | 2418 | EMRB | 0/0 | 100.0 | 100.0 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig00009 | 174 | 1364 | EMRD | 0/0 | 100.0 | 99.8 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00008 | 2550 | 3713 | EMRK | 0/0 | 100.0 | 99.9 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00847 | 684 | 1214 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00008 | 1012 | 2550 | EMRY | 0/0 | 100.0 | 99.1 | MEG_2736 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRY | NA |
| contig00054 | 2406 | 4049 | EPTA | 0/0 | 100.0 | 100.0 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00008 | 4748 | 8341 | EVGS | 0/0 | 100.0 | 99.7 | MEG_2870 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EVGS | NA |
| contig00317 | 1586 | 2314 | GADW | 0/0 | 100.0 | 100.0 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00317 | 394 | 1218 | GADX | 0/0 | 100.0 | 100.0 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00216 | 587 | 1021 | MARR | 0/0 | 100.0 | 100.0 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00173 | 4671 | 5903 | MDFA | 0/0 | 100.0 | 99.0 | MEG_3737 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDFA | NA |
| contig00766 | 215 | 1462 | MDTA | 0/0 | 100.0 | 98.2 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00136 | 2008 | 5085 | MDTC | 0/0 | 100.0 | 97.9 | MEG_3749 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTC | NA |
| contig00325 | 1236 | 2393 | MDTE | 0/0 | 100.0 | 100.0 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00562 | 772 | 1998 | MDTG | 0/0 | 100.0 | 100.0 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00495 | 2704 | 3033 | MDTI | 0/0 | 100.0 | 99.7 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00495 | 2352 | 2717 | MDTJ | 0/0 | 100.0 | 99.2 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00190 | 1 | 1204 | MDTM | 0/0 | 97.7 | 95.6 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00159 | 4593 | 6644 | MDTO | 0/0 | 100.0 | 100.0 | MEG_3764 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTO | NA |
| contig00159 | 3130 | 4596 | MDTP | 0/0 | 100.0 | 100.0 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00080 | 5870 | 6346 | MPHB | 0/0 | 100.0 | 98.3 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig01129 | 1 | 812 | OXA | 0/0 | 97.7 | 99.9 | MEG_4980 | Drugs:betalactams:Class_D_betalactamases:OXA | NA |
| contig00307 | 1513 | 3414 | PBP2 | 0/0 | 100.0 | 99.7 | MEG_5400 | Drugs:betalactams:Penicillin_binding_protein:PBP2 | NA |
| contig00883 | 144 | 1448 | PBP4B | 0/0 | 100.0 | 100.0 | MEG_5409 | Drugs:betalactams:Penicillin_binding_protein:PBP4B | NA |
| contig00546 | 668 | 1636 | PMRF | 0/0 | 100.0 | 100.0 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00044 | 9120 | 9989 | ROBA | 0/0 | 100.0 | 99.0 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00004 | 14455 | 14778 | SOXS | 0/0 | 100.0 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00417 | 2065 | 2880 | SULII | 0/0 | 100.0 | 100.0 | MEG_6617 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| contig00557 | 1439 | 2644 | TETB | 0/0 | 100.0 | 100.0 | MEG_7052 | Drugs:Tetracyclines:Tetracycline_resistance_MFS_efflux_pumps:TETB | NA |
| contig00262 | 1512 | 2678 | UGD | 0/0 | 100.0 | 98.9 | MEG_7328 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:UGD | NA |
| contig00550 | 1286 | 2792 | YOGI | 0/0 | 91.7 | 98.0 | MEG_7842 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_ABC_efflux_pumps:YOGI | NA |
## [1] "No antibiotic resitance genes from Resfinder database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01264 | 164 | 983 | bacA | 0/0 | 99.8 | 98.7 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00132 | 1565 | 2938 | cpxA | 0/0 | 100.0 | 98.5 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00118 | 2456 | 3059 | CRP | 0/0 | 95.4 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00662 | 1 | 1489 | eptA | 0/0 | 90.6 | 99.3 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00382 | 529 | 1722 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.8 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00158 | 687 | 1820 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.5 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00589 | 1 | 332 | Escherichia_coli_emrE | 0/0 | 99.7 | 92.2 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig01009 | 44 | 772 | gadW | 0/0 | 100.0 | 94.4 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig01912 | 220 | 603 | marA | 0/0 | 100.0 | 99.5 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00843 | 109 | 1266 | mdtE | 0/0 | 100.0 | 99.7 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00454 | 329 | 1360 | mdtN | 0/0 | 100.0 | 98.0 | AP009048.1:4307588-4306556 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride. | acridine_dye, nucleoside |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00158 | 687 | 1820 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.5 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00158 | 687 | 1820 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.5 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00382 | 529 | 1722 | ACRA | 0/0 | 100.0 | 99.8 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig01264 | 164 | 983 | BACA | 0/0 | 99.8 | 98.9 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00158 | 687 | 1820 | BLAEC | 0/0 | 100.0 | 98.2 | MEG_1279 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00132 | 870 | 1568 | CPXAR | 0/0 | 100.0 | 99.4 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00132 | 1565 | 2938 | CPXAR | 0/0 | 100.0 | 99.1 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00118 | 2456 | 3059 | CRP | 0/0 | 95.4 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00662 | 1 | 1489 | EPTA | 0/0 | 90.6 | 99.3 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig01009 | 44 | 772 | GADW | 0/0 | 100.0 | 98.6 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig01912 | 214 | 603 | MARA | 0/0 | 100.0 | 99.5 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00843 | 109 | 1266 | MDTE | 0/0 | 100.0 | 99.7 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00454 | 329 | 1360 | MDTN | 0/0 | 100.0 | 98.0 | MEG_3763 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTN | NA |
| contig00589 | 1 | 332 | MVRC | 0/0 | 99.7 | 92.2 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig00742 | 92 | 961 | ROBA | 0/0 | 100.0 | 99.3 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig01388 | 533 | 856 | SOXS | 0/0 | 100.0 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
## [1] "No antibiotic resitance genes from Resfinder database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00015 | 366 | 1190 | gadX | 0/0 | 100 | 97.9 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
## [1] "No antibiotic resitance genes from ARG-ANNOT database were found"
## [1] "No antibiotic resitance genes from NCBI database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00015 | 366 | 1190 | GADX | 0/0 | 100 | 97.9 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00947 | 844 | 1647 | aph(3’’)-Ib_5 | 0/0 | 100.0 | 100.0 | AF321551 | aph(3’’)-Ib | Streptomycin |
| contig00947 | 8 | 844 | aph(6)-Id_1 | 0/0 | 100.0 | 100.0 | M28829 | aph(6)-Id | Streptomycin |
| contig01185 | 1 | 792 | blaTEM-104_1 | 0/0 | 92.0 | 100.0 | AF516719 | blaTEM-104 | |
| contig00280 | 940 | 1599 | catA1_1 | 0/0 | 100.0 | 99.8 | V00622 | catA1 | Chloramphenicol |
| contig00019 | 2913 | 4145 | mdf(A)_1 | 0/0 | 100.0 | 98.0 | Y08743 | mdf(A) | |
| contig00689 | 928 | 2174 | tet(A)_6 | 0/0 | 97.8 | 100.0 | AF534183 | tet(A) | Doxycycline, Tetracycline |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01002 | 197 | 1354 | acrE | 0/0 | 100.0 | 98.3 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00401 | 2775 | 3437 | acrS | 0/0 | 100.0 | 97.4 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00947 | 844 | 1647 | APH(3’’)-Ib | 0/0 | 100.0 | 99.8 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig00947 | 8 | 844 | APH(6)-Id | 0/0 | 100.0 | 99.9 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig00172 | 283 | 1102 | bacA | 0/0 | 99.8 | 96.7 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00833 | 261 | 1664 | baeS | 0/0 | 100.0 | 97.1 | AP009048:2165012-2166416 | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance. | aminocoumarin, aminoglycoside |
| contig00280 | 940 | 1599 | catI | 0/0 | 100.0 | 99.8 | V00622:243-903 | catI is a chromosome and transposon-encoded variant of the cat gene found in Escherichia coli and Acinetobacter baumannii | phenicol |
| contig00950 | 277 | 1650 | cpxA | 0/0 | 100.0 | 98.3 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00408 | 2162 | 2794 | CRP | 0/0 | 100.0 | 99.0 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00444 | 219 | 1391 | emrA | 0/0 | 100.0 | 97.9 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig00432 | 2298 | 3305 | emrK | 0/0 | 95.5 | 97.9 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00444 | 1518 | 2048 | emrR | 0/0 | 100.0 | 99.4 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00432 | 760 | 2298 | emrY | 0/0 | 100.0 | 97.9 | D78168:1591-3130 | emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. | tetracycline |
| contig00277 | 2397 | 4040 | eptA | 0/0 | 100.0 | 98.2 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00359 | 2308 | 3501 | Escherichia_coli_acrA | 0/0 | 100.0 | 98.9 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00092 | 2723 | 3856 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.3 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00112 | 5016 | 6173 | Escherichia_coli_ampH | 0/0 | 100.0 | 96.7 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00019 | 2913 | 4145 | Escherichia_coli_mdfA | 0/0 | 100.0 | 96.5 | JQ394987:0-1233 | Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter. | benzalkonium_chloride, rhodamine, tetracycline |
| contig01110 | 329 | 943 | evgA | 0/0 | 100.0 | 99.2 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00283 | 1403 | 2131 | gadW | 0/0 | 100.0 | 95.9 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00283 | 210 | 1034 | gadX | 0/0 | 100.0 | 96.6 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00628 | 270 | 683 | H-NS | 0/0 | 100.0 | 99.5 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00205 | 1 | 673 | kdpE | 0/0 | 99.3 | 96.0 | U00096.3:721733-721055 | kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding. | aminoglycoside |
| contig00033 | 8217 | 8600 | marA | 0/0 | 100.0 | 99.7 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00671 | 154 | 1401 | mdtA | 0/0 | 100.0 | 97.1 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00144 | 739 | 3816 | mdtC | 0/0 | 100.0 | 96.3 | U00096:2158385-2161463 | MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58. | aminocoumarin |
| contig00835 | 1 | 1214 | mdtG | 0/0 | 98.9 | 98.6 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00262 | 1291 | 2499 | mdtH | 0/0 | 100.0 | 98.2 | U00096:1125326-1124117 | Multidrug resistance protein MdtH | fluoroquinolone |
| contig00180 | 2664 | 3896 | mdtM | 0/0 | 100.0 | 97.1 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00478 | 666 | 2717 | mdtO | 0/0 | 100.0 | 97.3 | AP009048.1:4306557-4304505 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00155 | 1199 | 1673 | mphB | 0/0 | 99.6 | 96.0 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00257 | 1820 | 2788 | pmrF | 0/0 | 100.0 | 98.5 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig01185 | 1 | 792 | TEM-104 | 0/0 | 92.0 | 100.0 | AF516719:214-1075 | TEM-104 is a beta-lactamase found in Klebsiella pneumoniae. | cephalosporin, monobactam, penam, penem |
| contig00689 | 928 | 2174 | tet(A) | 0/0 | 97.8 | 100.0 | AF534183.1:2970-4245 | TetA is a tetracycline efflux pump found in many species of Gram-negative bacteria. | tetracycline |
| contig00008 | 9704 | 11191 | tolC | 0/0 | 100.0 | 98.0 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| contig00440 | 78 | 1244 | ugd | 0/0 | 100.0 | 96.0 | U00096:2099613-2098446 | PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00947 | 844 | 1647 | (AGly)strA | 0/0 | 100 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00947 | 8 | 844 | (AGly)strB | 0/0 | 100 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00092 | 2723 | 3856 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.3 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00112 | 5016 | 6173 | (Bla)ampH_Ecoli | 0/0 | 100 | 96.7 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig01185 | 1 | 792 | (Bla)blaTEM-104 | 0/0 | 92 | 100.0 | AF516719:215-1075 | (Bla)blaTEM-104 | NA |
| contig00029 | 5460 | 7361 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 98.4 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00280 | 940 | 1599 | (Phe)catA1 | 0/0 | 100 | 99.8 | V00622:244-903 | (Phe)catA1 | NA |
| contig00689 | 900 | 2174 | (Tet)tetA | 0/0 | 100 | 100.0 | JX424423:94438-95712 | (Tet)tetA | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00947 | 844 | 1647 | (AGly)strA | 0/0 | 100 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00947 | 8 | 844 | (AGly)strB | 0/0 | 100 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00092 | 2723 | 3856 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.3 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00112 | 5016 | 6173 | (Bla)ampH_Ecoli | 0/0 | 100 | 96.7 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig01185 | 1 | 792 | (Bla)blaTEM-104 | 0/0 | 92 | 100.0 | AF516719:215-1075 | (Bla)blaTEM-104 | NA |
| contig00029 | 5460 | 7361 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 98.4 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00280 | 940 | 1599 | (Phe)catA1 | 0/0 | 100 | 99.8 | V00622:244-903 | (Phe)catA1 | NA |
| contig00689 | 900 | 2174 | (Tet)tetA | 0/0 | 100 | 100.0 | JX424423:94438-95712 | (Tet)tetA | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00359 | 2308 | 3501 | ACRA | 0/0 | 100.0 | 98.9 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig01002 | 197 | 1354 | ACRE | 0/0 | 100.0 | 98.3 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig00401 | 2775 | 3437 | ACRS | 0/0 | 100.0 | 97.4 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00112 | 5016 | 6173 | AMPH | 0/0 | 100.0 | 96.7 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00947 | 844 | 1669 | APH3-DPRIME | 0/0 | 99.8 | 100.0 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00947 | 8 | 844 | APH6 | 0/0 | 100.0 | 100.0 | MEG_1086 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig00249 | 2511 | 4363 | ASMA | 0/0 | 100.0 | 97.6 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00172 | 283 | 1102 | BACA | 0/0 | 99.8 | 97.0 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00833 | 261 | 1664 | BAES | 0/0 | 100.0 | 97.1 | MEG_1193 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAES | NA |
| contig00427 | 452 | 1642 | BCR | 0/0 | 100.0 | 96.1 | MEG_1210 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig00092 | 2723 | 3856 | BLAEC | 0/0 | 100.0 | 98.5 | MEG_1278 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00280 | 929 | 1599 | CATA | 0/0 | 100.0 | 100.0 | MEG_1593 | Drugs:Phenicol:Chloramphenicol_acetyltransferases:CATA | NA |
| contig00950 | 277 | 1650 | CPXAR | 0/0 | 100.0 | 98.5 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00408 | 2162 | 2794 | CRP | 0/0 | 100.0 | 99.0 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00444 | 219 | 1391 | EMRA | 0/0 | 100.0 | 97.9 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig00738 | 1101 | 2216 | EMRD | 0/0 | 93.7 | 97.8 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00444 | 1518 | 2048 | EMRR | 0/0 | 100.0 | 99.4 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00432 | 760 | 2298 | EMRY | 0/0 | 100.0 | 97.9 | MEG_2736 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRY | NA |
| contig00277 | 2397 | 4040 | EPTA | 0/0 | 100.0 | 98.2 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00283 | 1403 | 2131 | GADW | 0/0 | 100.0 | 97.5 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00283 | 210 | 1034 | GADX | 0/0 | 100.0 | 96.6 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00628 | 270 | 683 | HNS | 0/0 | 100.0 | 99.5 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00205 | 1 | 673 | KDPE | 0/0 | 99.3 | 96.0 | MEG_3448 | Drugs:Aminoglycosides:Aminoglycoside_efflux_pumps:KDPE | NA |
| contig00033 | 8217 | 8606 | MARA | 0/0 | 100.0 | 99.7 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00033 | 8621 | 9055 | MARR | 0/0 | 100.0 | 98.6 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00019 | 2913 | 4145 | MDFA | 0/0 | 100.0 | 98.1 | MEG_3737 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDFA | NA |
| contig00671 | 154 | 1401 | MDTA | 0/0 | 100.0 | 97.1 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00144 | 739 | 3816 | MDTC | 0/0 | 100.0 | 96.3 | MEG_3749 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTC | NA |
| contig00835 | 1 | 1214 | MDTG | 0/0 | 98.9 | 99.0 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00262 | 1291 | 2499 | MDTH | 0/0 | 100.0 | 98.2 | MEG_3755 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTH | NA |
| contig00461 | 147 | 512 | MDTJ | 0/0 | 100.0 | 98.4 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00180 | 2664 | 3896 | MDTM | 0/0 | 100.0 | 97.1 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00478 | 666 | 2717 | MDTO | 0/0 | 100.0 | 97.3 | MEG_3764 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTO | NA |
| contig00155 | 1199 | 1673 | MPHB | 0/0 | 99.6 | 96.0 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00029 | 5460 | 7361 | PBP2 | 0/0 | 100.0 | 98.4 | MEG_5400 | Drugs:betalactams:Penicillin_binding_protein:PBP2 | NA |
| contig00257 | 1820 | 2788 | PMRF | 0/0 | 100.0 | 98.5 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig01147 | 128 | 997 | ROBA | 0/0 | 100.0 | 99.3 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00616 | 592 | 914 | SOXS | 0/0 | 99.7 | 98.1 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig01185 | 1 | 1159 | TEM | 0/0 | 91.4 | 99.3 | MEG_6875 | Drugs:betalactams:Class_A_betalactamases:TEM | NA |
| contig00689 | 900 | 2174 | TETA | 0/0 | 100.0 | 100.0 | MEG_7024 | Drugs:Tetracyclines:Tetracycline_resistance_MFS_efflux_pumps:TETA | NA |
| contig00440 | 78 | 1244 | UGD | 0/0 | 100.0 | 96.0 | MEG_7328 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:UGD | NA |
## [1] "No antibiotic resitance genes from Resfinder database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00034 | 3553 | 6702 | acrB | 0/0 | 100.0 | 99.1 | U00096.3:484403-481253 | Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig01295 | 392 | 1054 | acrS | 0/0 | 100.0 | 99.2 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00060 | 2465 | 3187 | baeR | 0/0 | 100.0 | 99.3 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00060 | 1065 | 2468 | baeS | 0/0 | 100.0 | 98.2 | AP009048:2165012-2166416 | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance. | aminocoumarin, aminoglycoside |
| contig00121 | 3577 | 4950 | cpxA | 0/0 | 100.0 | 98.7 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00244 | 2146 | 2778 | CRP | 0/0 | 100.0 | 99.0 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00305 | 1508 | 2680 | emrA | 0/0 | 100.0 | 98.2 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig00422 | 1046 | 2101 | emrK | 0/0 | 100.0 | 99.7 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00305 | 851 | 1381 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00034 | 2337 | 3530 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.8 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00242 | 1846 | 2979 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.7 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00116 | 1096 | 2400 | Escherichia_coli_ampC1_beta-lactamase | 0/0 | 100.0 | 98.2 | FN649414.1:2765050-2766355 | An ampC-like beta-lactamase identified from Escherichia coli. | cephalosporin, penam |
| contig00047 | 1816 | 2973 | Escherichia_coli_ampH | 0/0 | 100.0 | 99.3 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00167 | 1454 | 2182 | gadW | 0/0 | 100.0 | 94.4 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00167 | 262 | 1086 | gadX | 0/0 | 100.0 | 97.9 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig01572 | 88 | 471 | marA | 0/0 | 100.0 | 99.5 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00546 | 215 | 1462 | mdtA | 0/0 | 100.0 | 98.3 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00609 | 927 | 2084 | mdtE | 0/0 | 100.0 | 99.7 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00663 | 1 | 1225 | mdtM | 0/0 | 99.3 | 95.8 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00093 | 2615 | 4081 | mdtP | 0/0 | 100.0 | 98.2 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig01899 | 1 | 433 | mphB | 0/0 | 90.8 | 97.5 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00719 | 485 | 1453 | pmrF | 0/0 | 100.0 | 99.5 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00020 | 3295 | 4782 | tolC | 0/0 | 100.0 | 98.4 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| contig00270 | 1 | 1628 | yojI | 0/0 | 99.0 | 98.2 | U00096.3:2308615-2306971 | YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00116 | 1096 | 2400 | (Bla)AmpC1_Ecoli | 0/0 | 100 | 98.2 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00242 | 1846 | 2979 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.7 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00047 | 1816 | 2973 | (Bla)ampH_Ecoli | 0/0 | 100 | 99.3 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00116 | 1096 | 2400 | (Bla)AmpC1_Ecoli | 0/0 | 100 | 98.2 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00242 | 1846 | 2979 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.7 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00047 | 1816 | 2973 | (Bla)ampH_Ecoli | 0/0 | 100 | 99.3 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00034 | 2337 | 3530 | ACRA | 0/0 | 100.0 | 99.8 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00034 | 3553 | 6702 | ACRB | 0/0 | 100.0 | 99.1 | MEG_401 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRB | NA |
| contig01295 | 392 | 1054 | ACRS | 0/0 | 100.0 | 99.2 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00047 | 1816 | 2973 | AMPH | 0/0 | 100.0 | 99.3 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00060 | 2465 | 3187 | BAER | 0/0 | 100.0 | 99.3 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00060 | 1065 | 2468 | BAES | 0/0 | 100.0 | 98.2 | MEG_1193 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAES | NA |
| contig00242 | 1846 | 2979 | BLAEC | 0/0 | 100.0 | 99.9 | MEG_1279 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00121 | 2882 | 3580 | CPXAR | 0/0 | 100.0 | 99.4 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00121 | 3577 | 4950 | CPXAR | 0/0 | 100.0 | 99.4 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00244 | 2146 | 2778 | CRP | 0/0 | 100.0 | 99.0 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00305 | 1508 | 2680 | EMRA | 0/0 | 100.0 | 98.2 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig00029 | 6037 | 7227 | EMRD | 0/0 | 100.0 | 99.9 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00422 | 1046 | 2209 | EMRK | 0/0 | 100.0 | 99.7 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00305 | 851 | 1381 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00167 | 1454 | 2182 | GADW | 0/0 | 100.0 | 98.6 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00167 | 262 | 1086 | GADX | 0/0 | 100.0 | 97.9 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig01572 | 82 | 471 | MARA | 0/0 | 100.0 | 99.5 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00546 | 215 | 1462 | MDTA | 0/0 | 100.0 | 98.3 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00609 | 927 | 2084 | MDTE | 0/0 | 100.0 | 99.7 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig01239 | 635 | 1000 | MDTJ | 0/0 | 100.0 | 99.2 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00339 | 1719 | 3092 | MDTK | 0/0 | 100.0 | 99.0 | MEG_3759 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MATE_efflux_pumps:MDTK | NA |
| contig00663 | 1 | 1225 | MDTM | 0/0 | 99.3 | 95.8 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00093 | 2615 | 4081 | MDTP | 0/0 | 100.0 | 98.2 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig01899 | 1 | 433 | MPHB | 0/0 | 90.8 | 97.5 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00116 | 1096 | 2400 | PBP4B | 0/0 | 100.0 | 98.2 | MEG_5409 | Drugs:betalactams:Penicillin_binding_protein:PBP4B | NA |
| contig00719 | 485 | 1453 | PMRF | 0/0 | 100.0 | 99.5 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00419 | 694 | 1563 | ROBA | 0/0 | 100.0 | 99.1 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00066 | 578 | 901 | SOXS | 0/0 | 100.0 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00270 | 1 | 1628 | YOGI | 0/0 | 99.0 | 98.2 | MEG_7842 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_ABC_efflux_pumps:YOGI | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00604 | 556 | 1359 | aph(3’’)-Ib_5 | 0/0 | 100 | 100.0 | AF321551 | aph(3’’)-Ib | Streptomycin |
| contig01209 | 6 | 866 | blaTEM-1B_1 | 0/0 | 100 | 100.0 | AY458016 | blaTEM-1B | Amoxicillin, Ampicillin, Cephalothin, Piperacillin, Ticarcillin |
| contig00125 | 1789 | 2262 | dfrA1_10 | 0/0 | 100 | 99.8 | AF203818 | dfrA1 | Trimethoprim |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00604 | 556 | 1359 | APH(3’’)-Ib | 0/0 | 100.0 | 99.8 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig00336 | 1127 | 2500 | cpxA | 0/0 | 100.0 | 99.0 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00157 | 1034 | 1666 | CRP | 0/0 | 100.0 | 99.4 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00125 | 1789 | 2262 | dfrA1 | 0/0 | 100.0 | 100.0 | KJ541681.1:19526-20000 | dfrA1 is an integron-encoded dihydrofolate reductase | diaminopyrimidine |
| contig00063 | 1557 | 2612 | emrK | 0/0 | 100.0 | 99.9 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig01134 | 185 | 715 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00063 | 19 | 1557 | emrY | 0/0 | 100.0 | 99.0 | D78168:1591-3130 | emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. | tetracycline |
| contig00013 | 2483 | 4126 | eptA | 0/0 | 100.0 | 99.4 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00308 | 661 | 1854 | Escherichia_coli_acrA | 0/0 | 100.0 | 100.0 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00435 | 940 | 2073 | Escherichia_coli_ampC | 0/0 | 100.0 | 98.4 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00003 | 2617 | 3774 | Escherichia_coli_ampH | 0/0 | 100.0 | 99.0 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig01004 | 731 | 1063 | Escherichia_coli_emrE | 0/0 | 100.0 | 91.9 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig00063 | 3136 | 3750 | evgA | 0/0 | 100.0 | 100.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00200 | 514 | 1242 | gadW | 0/0 | 100.0 | 94.4 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig02459 | 57 | 470 | H-NS | 0/0 | 100.0 | 99.8 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00592 | 1 | 1131 | mdtA | 0/0 | 90.6 | 100.0 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00243 | 1226 | 2383 | mdtE | 0/0 | 100.0 | 99.7 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00352 | 509 | 1735 | mdtG | 0/0 | 100.0 | 99.3 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00284 | 17 | 1483 | mdtP | 0/0 | 100.0 | 100.0 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00466 | 1299 | 1775 | mphB | 0/0 | 100.0 | 99.6 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig01209 | 6 | 866 | TEM-1 | 0/0 | 100.0 | 99.9 | AL513383:161910-162771 | TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. | cephalosporin, monobactam, penam, penem |
| contig00006 | 5960 | 7447 | tolC | 0/0 | 100.0 | 99.7 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00125 | 905 | 1706 | (AGly)aadA1-pm | 0/0 | 96.5 | 99.9 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00604 | 556 | 1359 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00435 | 940 | 2073 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 98.4 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00003 | 2617 | 3774 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 99.0 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig01209 | 6 | 866 | (Bla)blaTEM-105 | 0/0 | 100.0 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig01090 | 172 | 822 | (Tet)tetR | 0/0 | 100.0 | 100.0 | HF545434:53576-54226 | (Tet)tetR | NA |
| contig00125 | 1789 | 2262 | (Tmt)dfrA1 | 0/0 | 100.0 | 99.8 | JQ794607:474 | (Tmt)dfrA1 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00125 | 905 | 1706 | (AGly)aadA1-pm | 0/0 | 96.5 | 99.9 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00604 | 556 | 1359 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00435 | 940 | 2073 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 98.4 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00003 | 2617 | 3774 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 99.0 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig01209 | 6 | 866 | (Bla)blaTEM-105 | 0/0 | 100.0 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig01090 | 172 | 822 | (Tet)tetR | 0/0 | 100.0 | 100.0 | HF545434:53576-54226 | (Tet)tetR | NA |
| contig00125 | 1789 | 2262 | (Tmt)dfrA1 | 0/0 | 100.0 | 99.8 | JQ794607:474 | (Tmt)dfrA1 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00308 | 661 | 1854 | ACRA | 0/0 | 100.0 | 100.0 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00003 | 2617 | 3774 | AMPH | 0/0 | 100.0 | 99.0 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00125 | 905 | 1706 | ANT3-DPRIME | 0/0 | 96.5 | 99.9 | MEG_915 | Drugs:Aminoglycosides:Aminoglycoside_O-nucleotidyltransferases:ANT3-DPRIME | NA |
| contig00604 | 556 | 1383 | APH3-DPRIME | 0/0 | 100.0 | 100.0 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00651 | 1 | 1833 | ASMA | 0/0 | 98.9 | 98.1 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00435 | 940 | 2073 | BLAEC | 0/0 | 100.0 | 99.9 | MEG_1276 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00336 | 432 | 1130 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2122 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00336 | 1127 | 2500 | CPXAR | 0/0 | 100.0 | 99.8 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00157 | 1034 | 1666 | CRP | 0/0 | 100.0 | 99.4 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00125 | 1789 | 2262 | DFRA | 0/0 | 100.0 | 99.8 | MEG_2528 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00295 | 910 | 2100 | EMRD | 0/0 | 100.0 | 99.8 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00063 | 1557 | 2720 | EMRK | 0/0 | 100.0 | 99.9 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig01134 | 185 | 715 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00063 | 19 | 1557 | EMRY | 0/0 | 100.0 | 99.1 | MEG_2736 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRY | NA |
| contig00013 | 2483 | 4126 | EPTA | 0/0 | 100.0 | 99.4 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00200 | 514 | 1242 | GADW | 0/0 | 100.0 | 98.6 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig02459 | 57 | 470 | HNS | 0/0 | 100.0 | 99.8 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00592 | 1 | 1131 | MDTA | 0/0 | 90.6 | 100.0 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00243 | 1226 | 2383 | MDTE | 0/0 | 100.0 | 99.7 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00352 | 509 | 1735 | MDTG | 0/0 | 100.0 | 99.9 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig02004 | 260 | 625 | MDTJ | 0/0 | 100.0 | 99.2 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00284 | 17 | 1483 | MDTP | 0/0 | 100.0 | 100.0 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00466 | 1299 | 1775 | MPHB | 0/0 | 100.0 | 99.6 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig01004 | 731 | 1063 | MVRC | 0/0 | 100.0 | 91.9 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig00373 | 1362 | 2231 | ROBA | 0/0 | 100.0 | 99.0 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00042 | 1559 | 1882 | SOXS | 0/0 | 100.0 | 100.0 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig01209 | 1 | 1229 | TEM | 0/0 | 96.9 | 99.3 | MEG_6875 | Drugs:betalactams:Class_A_betalactamases:TEM | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00440 | 1392 | 2624 | mdf(A)_1 | 0/0 | 100 | 98.5 | Y08743 | mdf(A) | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00472 | 1 | 2919 | acrB | 0/0 | 92.7 | 99.0 | U00096.3:484403-481253 | Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00935 | 197 | 1354 | acrE | 0/0 | 100.0 | 98.8 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00085 | 4435 | 7308 | acrF | 0/0 | 92.6 | 99.0 | U00096:3415032-3418137 | AcrF is a inner membrane transporter similar to AcrB. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00247 | 4126 | 4788 | acrS | 0/0 | 100.0 | 99.4 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00333 | 2481 | 3884 | baeS | 0/0 | 100.0 | 99.6 | AP009048:2165012-2166416 | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance. | aminocoumarin, aminoglycoside |
| contig00240 | 3587 | 4960 | cpxA | 0/0 | 100.0 | 98.8 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00362 | 2156 | 2788 | CRP | 0/0 | 100.0 | 99.5 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00184 | 3493 | 5031 | emrB | 0/0 | 100.0 | 99.9 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig00886 | 662 | 1652 | emrK | 0/0 | 93.8 | 99.7 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig01004 | 228 | 758 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00061 | 2495 | 4138 | eptA | 0/0 | 100.0 | 99.3 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00364 | 2318 | 3511 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.8 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00022 | 7469 | 8602 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.7 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00026 | 5757 | 6914 | Escherichia_coli_ampH | 0/0 | 100.0 | 98.9 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00565 | 1362 | 1694 | Escherichia_coli_emrE | 0/0 | 100.0 | 91.9 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig00440 | 1392 | 2624 | Escherichia_coli_mdfA | 0/0 | 100.0 | 96.9 | JQ394987:0-1233 | Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter. | benzalkonium_chloride, rhodamine, tetracycline |
| contig00165 | 364 | 978 | evgA | 0/0 | 100.0 | 99.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00165 | 983 | 4576 | evgS | 0/0 | 100.0 | 98.9 | U00096:2484373-2487967 | EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00370 | 725 | 1453 | gadW | 0/0 | 100.0 | 94.4 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00154 | 5416 | 5829 | H-NS | 0/0 | 100.0 | 99.3 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig01198 | 309 | 943 | kdpE | 0/0 | 93.7 | 97.2 | U00096.3:721733-721055 | kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding. | aminoglycoside |
| contig00357 | 2066 | 2449 | marA | 0/0 | 100.0 | 99.5 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00412 | 1236 | 2393 | mdtE | 0/0 | 100.0 | 99.7 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00122 | 4636 | 5862 | mdtG | 0/0 | 100.0 | 99.3 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00072 | 3426 | 4634 | mdtH | 0/0 | 100.0 | 98.6 | U00096:1125326-1124117 | Multidrug resistance protein MdtH | fluoroquinolone |
| contig00016 | 821 | 2053 | mdtM | 0/0 | 100.0 | 96.1 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00027 | 8561 | 10612 | mdtO | 0/0 | 100.0 | 98.7 | AP009048.1:4306557-4304505 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00027 | 7098 | 8564 | mdtP | 0/0 | 100.0 | 98.2 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00201 | 289 | 765 | mphB | 0/0 | 100.0 | 98.1 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00052 | 6132 | 7100 | pmrF | 0/0 | 100.0 | 99.4 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00058 | 376 | 1863 | tolC | 0/0 | 100.0 | 98.5 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| contig00371 | 108 | 1751 | yojI | 0/0 | 100.0 | 98.5 | U00096.3:2308615-2306971 | YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00022 | 7469 | 8602 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.7 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00026 | 5757 | 6914 | (Bla)ampH_Ecoli | 0/0 | 100 | 98.9 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00022 | 7469 | 8602 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.7 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00026 | 5757 | 6914 | (Bla)ampH_Ecoli | 0/0 | 100 | 98.9 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00364 | 2318 | 3511 | ACRA | 0/0 | 100.0 | 99.8 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00472 | 1 | 2919 | ACRB | 0/0 | 92.7 | 99.0 | MEG_401 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRB | NA |
| contig00935 | 197 | 1354 | ACRE | 0/0 | 100.0 | 98.8 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig00085 | 4435 | 7308 | ACRF | 0/0 | 92.6 | 99.0 | MEG_409 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRF | NA |
| contig00247 | 4126 | 4788 | ACRS | 0/0 | 100.0 | 99.4 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00026 | 5757 | 6914 | AMPH | 0/0 | 100.0 | 98.9 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00564 | 865 | 2689 | ASMA | 0/0 | 98.4 | 96.1 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00333 | 2481 | 3884 | BAES | 0/0 | 100.0 | 99.6 | MEG_1193 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAES | NA |
| contig00022 | 7469 | 8602 | BLAEC | 0/0 | 100.0 | 99.2 | MEG_1279 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00240 | 2892 | 3590 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2122 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00240 | 3587 | 4960 | CPXAR | 0/0 | 100.0 | 99.5 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00362 | 2156 | 2788 | CRP | 0/0 | 100.0 | 99.5 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00184 | 3493 | 5031 | EMRB | 0/0 | 100.0 | 99.9 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig00226 | 3772 | 4962 | EMRD | 0/0 | 100.0 | 99.8 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig01004 | 228 | 758 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00061 | 2495 | 4138 | EPTA | 0/0 | 100.0 | 99.3 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00165 | 983 | 4576 | EVGS | 0/0 | 100.0 | 98.9 | MEG_2870 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EVGS | NA |
| contig00370 | 725 | 1453 | GADW | 0/0 | 100.0 | 98.6 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00154 | 5416 | 5829 | HNS | 0/0 | 100.0 | 99.3 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig01198 | 309 | 943 | KDPE | 0/0 | 93.7 | 97.2 | MEG_3448 | Drugs:Aminoglycosides:Aminoglycoside_efflux_pumps:KDPE | NA |
| contig00357 | 2060 | 2449 | MARA | 0/0 | 100.0 | 99.5 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00357 | 1612 | 2046 | MARR | 0/0 | 100.0 | 98.2 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00440 | 1392 | 2624 | MDFA | 0/0 | 100.0 | 98.5 | MEG_3737 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDFA | NA |
| contig00412 | 1236 | 2393 | MDTE | 0/0 | 100.0 | 99.7 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00122 | 4636 | 5862 | MDTG | 0/0 | 100.0 | 99.5 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00072 | 3426 | 4634 | MDTH | 0/0 | 100.0 | 98.6 | MEG_3755 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTH | NA |
| contig00016 | 821 | 2053 | MDTM | 0/0 | 100.0 | 96.1 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00027 | 8561 | 10612 | MDTO | 0/0 | 100.0 | 98.7 | MEG_3764 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTO | NA |
| contig00027 | 7098 | 8564 | MDTP | 0/0 | 100.0 | 98.2 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00201 | 289 | 765 | MPHB | 0/0 | 100.0 | 98.1 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00565 | 1362 | 1694 | MVRC | 0/0 | 100.0 | 91.9 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig00052 | 6132 | 7100 | PMRF | 0/0 | 100.0 | 99.4 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00062 | 5976 | 6845 | ROBA | 0/0 | 100.0 | 99.2 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00010 | 5613 | 5936 | SOXS | 0/0 | 100.0 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00371 | 108 | 1751 | YOGI | 0/0 | 100.0 | 98.5 | MEG_7842 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_ABC_efflux_pumps:YOGI | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00667 | 1332 | 1757 | fosA_7 | 0/0 | 100 | 96.5 | AEXB01000013 | fosA | Fosfomycin |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00588 | 1053 | 2246 | Enterobacter_cloacae_acrA | 0/0 | 100 | 94.9 | DQ679966:299-1493 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. cloacae. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00667 | 1332 | 1757 | FosA2 | 0/0 | 100 | 92.0 | EU487198:216-642 | An enzyme that confers resistance to fosfomycin in Enterobacter cloacae by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. | fosfomycin |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00667 | 1332 | 1757 | (Fcyn)FosA2 | 0/0 | 100 | 92 | EU487198:217-642 | (Fcyn)FosA2 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00667 | 1332 | 1757 | (Fcyn)FosA2 | 0/0 | 100 | 92 | EU487198:217-642 | (Fcyn)FosA2 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00588 | 1053 | 2246 | ACRB | 0/0 | 100.0 | 94.9 | MEG_402 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRB | NA |
| contig00488 | 1757 | 2816 | ACT | 0/0 | 92.5 | 99.1 | MEG_439 | Drugs:betalactams:Class_C_betalactamases:ACT | NA |
| contig00667 | 1332 | 1913 | FOSA | 0/0 | 100.0 | 92.6 | MEG_2990 | Drugs:Fosfomycin:Fosfomycin_thiol_transferases:FOSA | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00196 | 1963 | 3195 | mdf(A)_1 | 0/0 | 100 | 97.9 | Y08743 | mdf(A) | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00952 | 197 | 1283 | acrE | 0/0 | 93.9 | 98.6 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00774 | 1083 | 1745 | acrS | 0/0 | 100.0 | 98.3 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00577 | 1958 | 2777 | bacA | 0/0 | 99.8 | 98.2 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00599 | 1392 | 2113 | baeR | 0/0 | 99.9 | 97.0 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00599 | 1 | 1395 | baeS | 0/0 | 99.4 | 90.5 | AP009048:2165012-2166416 | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance. | aminocoumarin, aminoglycoside |
| contig00631 | 1127 | 2500 | cpxA | 0/0 | 100.0 | 98.4 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00145 | 2675 | 3307 | CRP | 0/0 | 100.0 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00054 | 3216 | 4388 | emrA | 0/0 | 100.0 | 98.1 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig00054 | 4405 | 5943 | emrB | 0/0 | 100.0 | 98.2 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig00009 | 4153 | 5208 | emrK | 0/0 | 100.0 | 97.5 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00054 | 2559 | 3089 | emrR | 0/0 | 100.0 | 98.7 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00009 | 2615 | 4153 | emrY | 0/0 | 100.0 | 97.8 | D78168:1591-3130 | emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. | tetracycline |
| contig00039 | 2507 | 4150 | eptA | 0/0 | 100.0 | 90.9 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00706 | 208 | 1401 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.2 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00086 | 3660 | 4793 | Escherichia_coli_ampC | 0/0 | 100.0 | 98.1 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00108 | 2314 | 3471 | Escherichia_coli_ampH | 0/0 | 100.0 | 97.4 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00052 | 1080 | 1412 | Escherichia_coli_emrE | 0/0 | 100.0 | 92.2 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig00196 | 1963 | 3195 | Escherichia_coli_mdfA | 0/0 | 100.0 | 96.3 | JQ394987:0-1233 | Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter. | benzalkonium_chloride, rhodamine, tetracycline |
| contig00009 | 5732 | 6346 | evgA | 0/0 | 100.0 | 98.9 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00009 | 6351 | 9944 | evgS | 0/0 | 100.0 | 96.2 | U00096:2484373-2487967 | EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00334 | 21 | 749 | gadW | 0/0 | 100.0 | 99.6 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00926 | 365 | 1189 | gadX | 0/0 | 100.0 | 93.9 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00684 | 1 | 632 | kdpE | 0/0 | 93.2 | 96.0 | U00096.3:721733-721055 | kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding. | aminoglycoside |
| contig00059 | 5216 | 5599 | marA | 0/0 | 100.0 | 98.2 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00334 | 1112 | 4225 | mdtF | 0/0 | 100.0 | 97.3 | U00096:3660413-3663527 | MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex. | fluoroquinolone, macrolide, penam |
| contig00353 | 733 | 1959 | mdtG | 0/0 | 100.0 | 98.1 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00266 | 367 | 1398 | mdtN | 0/0 | 100.0 | 95.5 | AP009048.1:4307588-4306556 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride. | acridine_dye, nucleoside |
| contig00266 | 1398 | 3449 | mdtO | 0/0 | 100.0 | 96.9 | AP009048.1:4306557-4304505 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00266 | 3446 | 4912 | mdtP | 0/0 | 100.0 | 97.5 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00051 | 5071 | 6819 | msbA | 0/0 | 100.0 | 98.1 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| contig00159 | 4360 | 5328 | pmrF | 0/0 | 100.0 | 97.8 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00044 | 6944 | 8431 | tolC | 0/0 | 100.0 | 98.1 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00086 | 3660 | 4793 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 98.1 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00108 | 2314 | 3471 | (Bla)ampH_Ecoli | 0/0 | 100 | 97.4 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00086 | 3660 | 4793 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 98.1 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00108 | 2314 | 3471 | (Bla)ampH_Ecoli | 0/0 | 100 | 97.4 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00706 | 208 | 1401 | ACRA | 0/0 | 100.0 | 99.2 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00952 | 197 | 1283 | ACRE | 0/0 | 93.9 | 98.6 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig00774 | 1083 | 1745 | ACRS | 0/0 | 100.0 | 98.3 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00108 | 2314 | 3471 | AMPH | 0/0 | 100.0 | 97.4 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00406 | 1889 | 3742 | ASMA | 0/0 | 100.0 | 98.0 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00577 | 1958 | 2777 | BACA | 0/0 | 99.8 | 98.4 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00599 | 1392 | 2113 | BAER | 0/0 | 99.9 | 97.0 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00599 | 1 | 1395 | BAES | 0/0 | 99.4 | 90.5 | MEG_1193 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAES | NA |
| contig00005 | 14028 | 15218 | BCR | 0/0 | 100.0 | 96.3 | MEG_1210 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig00086 | 3660 | 4793 | BLAEC | 0/0 | 100.0 | 99.9 | MEG_1275 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00631 | 432 | 1130 | CPXAR | 0/0 | 100.0 | 97.8 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00631 | 1127 | 2500 | CPXAR | 0/0 | 100.0 | 98.8 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00145 | 2675 | 3307 | CRP | 0/0 | 100.0 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00054 | 3216 | 4388 | EMRA | 0/0 | 100.0 | 98.1 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig00054 | 4405 | 5943 | EMRB | 0/0 | 100.0 | 98.2 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig00100 | 2625 | 3815 | EMRD | 0/0 | 100.0 | 98.2 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00009 | 4153 | 5316 | EMRK | 0/0 | 100.0 | 97.3 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00054 | 2559 | 3089 | EMRR | 0/0 | 100.0 | 98.7 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00009 | 2615 | 4153 | EMRY | 0/0 | 100.0 | 97.9 | MEG_2736 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRY | NA |
| contig00039 | 2507 | 4150 | EPTA | 0/0 | 100.0 | 90.9 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00009 | 6351 | 9944 | EVGS | 0/0 | 100.0 | 97.3 | MEG_2869 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EVGS | NA |
| contig00334 | 21 | 749 | GADW | 0/0 | 100.0 | 99.6 | MEG_3082 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00926 | 365 | 1189 | GADX | 0/0 | 100.0 | 93.9 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00684 | 1 | 632 | KDPE | 0/0 | 93.2 | 96.0 | MEG_3448 | Drugs:Aminoglycosides:Aminoglycoside_efflux_pumps:KDPE | NA |
| contig00059 | 5216 | 5605 | MARA | 0/0 | 100.0 | 98.2 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00059 | 5620 | 6054 | MARR | 0/0 | 100.0 | 98.4 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00196 | 1963 | 3195 | MDFA | 0/0 | 100.0 | 98.0 | MEG_3737 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDFA | NA |
| contig00334 | 1112 | 4225 | MDTF | 0/0 | 100.0 | 97.3 | MEG_3752 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTF | NA |
| contig00353 | 733 | 1959 | MDTG | 0/0 | 100.0 | 98.2 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00084 | 6685 | 7014 | MDTI | 0/0 | 100.0 | 98.8 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00084 | 6333 | 6698 | MDTJ | 0/0 | 100.0 | 97.5 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00501 | 1824 | 3197 | MDTK | 0/0 | 100.0 | 98.0 | MEG_3759 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MATE_efflux_pumps:MDTK | NA |
| contig00266 | 367 | 1398 | MDTN | 0/0 | 100.0 | 95.5 | MEG_3763 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTN | NA |
| contig00266 | 1398 | 3449 | MDTO | 0/0 | 100.0 | 96.9 | MEG_3764 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTO | NA |
| contig00266 | 3446 | 4912 | MDTP | 0/0 | 100.0 | 97.5 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00051 | 5071 | 6819 | MSBA | 0/0 | 100.0 | 98.1 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
| contig00052 | 1080 | 1412 | MVRC | 0/0 | 100.0 | 92.2 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig00159 | 4360 | 5328 | PMRF | 0/0 | 100.0 | 97.8 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00110 | 5335 | 6204 | ROBA | 0/0 | 100.0 | 97.2 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
## [1] "No antibiotic resitance genes from Resfinder database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01906 | 205 | 781 | CRP | 0/0 | 91.2 | 99.3 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00049 | 105 | 1643 | emrB | 0/0 | 100.0 | 99.8 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig01375 | 1 | 1008 | emrK | 0/0 | 95.5 | 99.9 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00472 | 161 | 691 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00236 | 1 | 1568 | eptA | 0/0 | 95.4 | 100.0 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00401 | 67 | 1260 | Escherichia_coli_acrA | 0/0 | 100.0 | 100.0 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00761 | 412 | 1545 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.3 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig01066 | 1 | 1276 | Escherichia_coli_ampC1_beta-lactamase | 0/0 | 97.8 | 100.0 | FN649414.1:2765050-2766355 | An ampC-like beta-lactamase identified from Escherichia coli. | cephalosporin, penam |
| contig01206 | 311 | 925 | evgA | 0/0 | 100.0 | 100.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00908 | 2 | 826 | gadX | 0/0 | 100.0 | 100.0 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00010 | 3508 | 3921 | H-NS | 0/0 | 100.0 | 99.5 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00624 | 650 | 1033 | marA | 0/0 | 100.0 | 99.7 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00975 | 1 | 1130 | mdtA | 0/0 | 90.5 | 97.2 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00244 | 918 | 2075 | mdtE | 0/0 | 100.0 | 100.0 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00117 | 909 | 2117 | mdtH | 0/0 | 100.0 | 99.9 | U00096:1125326-1124117 | Multidrug resistance protein MdtH | fluoroquinolone |
| contig00072 | 651 | 2399 | msbA | 0/0 | 100.0 | 100.0 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01066 | 1 | 1276 | (Bla)AmpC1_Ecoli | 0/0 | 97.8 | 100.0 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00761 | 412 | 1545 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 97.3 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01066 | 1 | 1276 | (Bla)AmpC1_Ecoli | 0/0 | 97.8 | 100.0 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00761 | 412 | 1545 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 97.3 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00401 | 67 | 1260 | ACRA | 0/0 | 100.0 | 100.0 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00761 | 412 | 1545 | BLAEC | 0/0 | 100.0 | 98.6 | MEG_1282 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig01079 | 293 | 991 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2122 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig01906 | 205 | 781 | CRP | 0/0 | 91.2 | 99.3 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00049 | 105 | 1643 | EMRB | 0/0 | 100.0 | 99.8 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig00472 | 161 | 691 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00236 | 1 | 1568 | EPTA | 0/0 | 95.4 | 100.0 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00908 | 2 | 826 | GADX | 0/0 | 100.0 | 100.0 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00010 | 3508 | 3921 | HNS | 0/0 | 100.0 | 99.5 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00624 | 644 | 1033 | MARA | 0/0 | 100.0 | 99.7 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00624 | 195 | 629 | MARR | 0/0 | 100.0 | 98.4 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00975 | 1 | 1130 | MDTA | 0/0 | 90.5 | 97.2 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00244 | 918 | 2075 | MDTE | 0/0 | 100.0 | 100.0 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00117 | 909 | 2117 | MDTH | 0/0 | 100.0 | 99.9 | MEG_3755 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTH | NA |
| contig00877 | 1000 | 1365 | MDTJ | 0/0 | 100.0 | 99.2 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00072 | 651 | 2399 | MSBA | 0/0 | 100.0 | 100.0 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
| contig01066 | 1 | 1276 | PBP4B | 0/0 | 97.8 | 100.0 | MEG_5409 | Drugs:betalactams:Penicillin_binding_protein:PBP4B | NA |
| contig01024 | 199 | 1068 | ROBA | 0/0 | 100.0 | 99.1 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00784 | 766 | 1088 | SOXS | 0/0 | 99.7 | 99.4 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
## [1] "No antibiotic resitance genes from Resfinder database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00220 | 2614 | 3276 | acrS | 0/0 | 100.0 | 99.8 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00904 | 49 | 868 | bacA | 0/0 | 99.8 | 98.2 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00675 | 617 | 1339 | baeR | 0/0 | 100.0 | 98.3 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00388 | 620 | 1252 | CRP | 0/0 | 100.0 | 99.4 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00173 | 522 | 1694 | emrA | 0/0 | 100.0 | 98.2 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig00328 | 1774 | 2829 | emrK | 0/0 | 100.0 | 98.9 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00173 | 1821 | 2351 | emrR | 0/0 | 100.0 | 99.6 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00328 | 236 | 1774 | emrY | 0/0 | 100.0 | 98.6 | D78168:1591-3130 | emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. | tetracycline |
| contig00071 | 409 | 2052 | eptA | 0/0 | 100.0 | 99.5 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00086 | 158 | 1291 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.6 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00014 | 3981 | 5138 | Escherichia_coli_ampH | 0/0 | 100.0 | 98.8 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00863 | 138 | 752 | evgA | 0/0 | 100.0 | 99.2 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00776 | 20 | 748 | gadW | 0/0 | 100.0 | 94.9 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00958 | 584 | 1408 | gadX | 0/0 | 100.0 | 98.9 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00017 | 1186 | 1599 | H-NS | 0/0 | 100.0 | 99.5 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00288 | 951 | 1334 | marA | 0/0 | 100.0 | 99.2 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00108 | 2447 | 3604 | mdtE | 0/0 | 100.0 | 99.2 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00407 | 517 | 1743 | mdtG | 0/0 | 100.0 | 98.7 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00179 | 1801 | 3033 | mdtM | 0/0 | 100.0 | 95.9 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00857 | 364 | 1395 | mdtN | 0/0 | 100.0 | 98.2 | AP009048.1:4307588-4306556 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride. | acridine_dye, nucleoside |
| contig00202 | 60 | 1526 | mdtP | 0/0 | 100.0 | 97.6 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig01697 | 7 | 483 | mphB | 0/0 | 100.0 | 98.5 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00380 | 470 | 1957 | tolC | 0/0 | 100.0 | 98.8 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00086 | 158 | 1291 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.6 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00014 | 3981 | 5138 | (Bla)ampH_Ecoli | 0/0 | 100 | 98.8 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00086 | 158 | 1291 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.6 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00014 | 3981 | 5138 | (Bla)ampH_Ecoli | 0/0 | 100 | 98.8 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00220 | 2614 | 3276 | ACRS | 0/0 | 100.0 | 99.8 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00014 | 3981 | 5138 | AMPH | 0/0 | 100.0 | 98.8 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00199 | 1569 | 3421 | ASMA | 0/0 | 100.0 | 98.9 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00904 | 49 | 868 | BACA | 0/0 | 99.8 | 98.2 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00675 | 617 | 1339 | BAER | 0/0 | 100.0 | 98.3 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00852 | 1 | 1172 | BCR | 0/0 | 98.4 | 97.3 | MEG_1210 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig00086 | 158 | 1291 | BLAEC | 0/0 | 100.0 | 99.1 | MEG_1279 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00388 | 620 | 1252 | CRP | 0/0 | 100.0 | 99.4 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00173 | 522 | 1694 | EMRA | 0/0 | 100.0 | 98.2 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig00328 | 1774 | 2869 | EMRK | 0/0 | 94.2 | 98.8 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00173 | 1821 | 2351 | EMRR | 0/0 | 100.0 | 99.6 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00328 | 236 | 1774 | EMRY | 0/0 | 100.0 | 98.6 | MEG_2736 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRY | NA |
| contig00071 | 409 | 2052 | EPTA | 0/0 | 100.0 | 99.5 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00776 | 20 | 748 | GADW | 0/0 | 100.0 | 99.2 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00958 | 584 | 1408 | GADX | 0/0 | 100.0 | 98.9 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00017 | 1186 | 1599 | HNS | 0/0 | 100.0 | 99.5 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00288 | 945 | 1334 | MARA | 0/0 | 100.0 | 99.2 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00288 | 497 | 931 | MARR | 0/0 | 100.0 | 97.9 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00108 | 2447 | 3604 | MDTE | 0/0 | 100.0 | 99.2 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00407 | 517 | 1743 | MDTG | 0/0 | 100.0 | 98.9 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig01182 | 96 | 425 | MDTI | 0/0 | 100.0 | 99.4 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00179 | 1801 | 3033 | MDTM | 0/0 | 100.0 | 95.9 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00857 | 364 | 1395 | MDTN | 0/0 | 100.0 | 98.2 | MEG_3763 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTN | NA |
| contig00202 | 60 | 1526 | MDTP | 0/0 | 100.0 | 97.6 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig01697 | 7 | 483 | MPHB | 0/0 | 100.0 | 98.5 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00476 | 297 | 1166 | ROBA | 0/0 | 100.0 | 99.1 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00838 | 25 | 347 | SOXS | 0/0 | 99.7 | 98.8 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00100 | 2676 | 3149 | dfrA15_2 | 0/0 | 100 | 100.0 | AF221900 | dfrA15 | Trimethoprim |
| contig00100 | 439 | 1305 | sul1_5 | 0/0 | 100 | 99.9 | EU780013 | sul1 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00980 | 187 | 1344 | acrE | 0/0 | 100.0 | 98.8 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig01545 | 98 | 917 | bacA | 0/0 | 99.8 | 98.9 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00090 | 2806 | 4209 | baeS | 0/0 | 100.0 | 99.7 | AP009048:2165012-2166416 | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance. | aminocoumarin, aminoglycoside |
| contig01048 | 1 | 1362 | cpxA | 0/0 | 99.1 | 98.8 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00102 | 447 | 1079 | CRP | 0/0 | 100.0 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00100 | 2676 | 3149 | dfrA15 | 0/0 | 100.0 | 100.0 | KF534911:39-513 | dfrA15 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae | diaminopyrimidine |
| contig01093 | 286 | 1321 | emrK | 0/0 | 98.1 | 99.7 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig01525 | 31 | 561 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00026 | 4748 | 5905 | Escherichia_coli_ampH | 0/0 | 100.0 | 98.9 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig01440 | 206 | 820 | evgA | 0/0 | 100.0 | 99.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00252 | 97 | 825 | gadW | 0/0 | 100.0 | 94.4 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig01473 | 225 | 984 | gadX | 0/0 | 92.1 | 97.9 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00707 | 177 | 1424 | mdtA | 0/0 | 100.0 | 98.2 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00384 | 573 | 1799 | mdtG | 0/0 | 100.0 | 99.3 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00020 | 3138 | 4604 | mdtP | 0/0 | 100.0 | 98.2 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00214 | 349 | 1317 | pmrF | 0/0 | 100.0 | 99.4 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00100 | 439 | 1278 | sul1 | 0/0 | 100.0 | 100.0 | JF969163:1053-1893 | Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons. | sulfonamide |
| contig00048 | 3489 | 4976 | tolC | 0/0 | 100.0 | 98.5 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00100 | 1783 | 2584 | (AGly)aadA1-pm | 0/0 | 96.5 | 96.4 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00026 | 4748 | 5905 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 98.9 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00100 | 439 | 1278 | (Sul)sul1 | 0/0 | 100.0 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig00100 | 2676 | 3149 | (Tmt)dfrA15b | 0/0 | 100.0 | 99.2 | AJ867237:177-650 | (Tmt)dfrA15b | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00100 | 1783 | 2584 | (AGly)aadA1-pm | 0/0 | 96.5 | 96.4 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00026 | 4748 | 5905 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 98.9 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00100 | 439 | 1278 | (Sul)sul1 | 0/0 | 100.0 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig00100 | 2676 | 3149 | (Tmt)dfrA15b | 0/0 | 100.0 | 99.2 | AJ867237:177-650 | (Tmt)dfrA15b | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00980 | 187 | 1344 | ACRE | 0/0 | 100.0 | 98.8 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig00026 | 4748 | 5905 | AMPH | 0/0 | 100.0 | 98.9 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig01545 | 98 | 917 | BACA | 0/0 | 99.8 | 98.9 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00090 | 2806 | 4209 | BAES | 0/0 | 100.0 | 99.7 | MEG_1193 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAES | NA |
| contig00211 | 1263 | 2453 | BCR | 0/0 | 100.0 | 98.2 | MEG_1210 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig01048 | 1 | 1362 | CPXAR | 0/0 | 99.1 | 99.6 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00102 | 447 | 1079 | CRP | 0/0 | 100.0 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00100 | 2676 | 3149 | DFRA | 0/0 | 100.0 | 99.4 | MEG_2492 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00183 | 2230 | 3353 | EMRD | 0/0 | 94.4 | 99.9 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig01525 | 31 | 561 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00252 | 97 | 825 | GADW | 0/0 | 100.0 | 98.6 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig01473 | 225 | 984 | GADX | 0/0 | 92.1 | 97.9 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig01387 | 346 | 780 | MARR | 0/0 | 100.0 | 98.2 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00707 | 177 | 1424 | MDTA | 0/0 | 100.0 | 98.2 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00384 | 573 | 1799 | MDTG | 0/0 | 100.0 | 99.4 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00020 | 3138 | 4604 | MDTP | 0/0 | 100.0 | 98.2 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00214 | 349 | 1317 | PMRF | 0/0 | 100.0 | 99.4 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00986 | 176 | 1045 | ROBA | 0/0 | 100.0 | 98.8 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00124 | 2083 | 2406 | SOXS | 0/0 | 100.0 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00100 | 312 | 1279 | SULI | 0/0 | 100.0 | 100.0 | MEG_6615 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULI | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00015 | 2698 | 3534 | aph(6)-Id_1 | 0/0 | 100 | 100.0 | M28829 | aph(6)-Id | Streptomycin |
| contig00015 | 3884 | 4366 | dfrA14_5 | 0/0 | 100 | 99.8 | DQ388123 | dfrA14 | Trimethoprim |
| contig00015 | 4966 | 5781 | sul2_2 | 0/0 | 100 | 100.0 | AY034138 | sul2 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00015 | 2698 | 3534 | APH(6)-Id | 0/0 | 100.0 | 99.9 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig00981 | 174 | 896 | baeR | 0/0 | 100.0 | 96.3 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00146 | 2306 | 2938 | CRP | 0/0 | 100.0 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00015 | 3884 | 4366 | dfrA14 | 0/0 | 100.0 | 100.0 | EU780012:2162-2645 | dfrA14 is an integron-encoded dihydrofolate reductase found in Escherichia coli | diaminopyrimidine |
| contig00422 | 1 | 1103 | emrA | 0/0 | 94.0 | 97.8 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig02586 | 1 | 523 | emrR | 0/0 | 98.5 | 99.4 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00131 | 1 | 1481 | eptA | 0/0 | 90.1 | 97.0 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00039 | 2681 | 3814 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.9 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig01343 | 129 | 461 | Escherichia_coli_emrE | 0/0 | 100.0 | 91.6 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig01046 | 20 | 634 | evgA | 0/0 | 100.0 | 99.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig01060 | 168 | 896 | gadW | 0/0 | 100.0 | 96.6 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig01564 | 1 | 824 | gadX | 0/0 | 99.9 | 93.9 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig02681 | 168 | 560 | H-NS | 0/0 | 94.9 | 99.5 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00334 | 561 | 1718 | mdtE | 0/0 | 100.0 | 98.5 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00069 | 147 | 2198 | mdtO | 0/0 | 100.0 | 97.0 | AP009048.1:4306557-4304505 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00069 | 2195 | 3661 | mdtP | 0/0 | 100.0 | 96.5 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00976 | 728 | 1202 | mphB | 0/0 | 99.6 | 97.0 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00015 | 4966 | 5781 | sul2 | 0/0 | 100.0 | 100.0 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig00757 | 1 | 1535 | yojI | 0/0 | 93.4 | 97.5 | U00096.3:2308615-2306971 | YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00015 | 2698 | 3534 | (AGly)strB | 0/0 | 100 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00039 | 2681 | 3814 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.9 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00015 | 4966 | 5781 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00015 | 3884 | 4357 | (Tmt)dfrA14 | 0/0 | 100 | 99.8 | GU726917:72-545 | (Tmt)dfrA14 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00015 | 2698 | 3534 | (AGly)strB | 0/0 | 100 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00039 | 2681 | 3814 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.9 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00015 | 4966 | 5781 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00015 | 3884 | 4357 | (Tmt)dfrA14 | 0/0 | 100 | 99.8 | GU726917:72-545 | (Tmt)dfrA14 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00015 | 2698 | 3534 | APH6 | 0/0 | 100.0 | 100.0 | MEG_1086 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig00981 | 174 | 896 | BAER | 0/0 | 100.0 | 96.3 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00907 | 158 | 1348 | BCR | 0/0 | 100.0 | 96.4 | MEG_1210 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig00039 | 2681 | 3814 | BLAEC | 0/0 | 100.0 | 99.2 | MEG_1275 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig01691 | 177 | 875 | CPXAR | 0/0 | 100.0 | 99.4 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00146 | 2306 | 2938 | CRP | 0/0 | 100.0 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00015 | 3884 | 4357 | DFRA | 0/0 | 100.0 | 100.0 | MEG_2517 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00422 | 1 | 1103 | EMRA | 0/0 | 94.0 | 97.8 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig02586 | 1 | 523 | EMRR | 0/0 | 98.5 | 99.4 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00131 | 1 | 1481 | EPTA | 0/0 | 90.1 | 97.0 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig01060 | 168 | 896 | GADW | 0/0 | 100.0 | 96.8 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig01564 | 1 | 824 | GADX | 0/0 | 99.9 | 93.9 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig02681 | 168 | 560 | HNS | 0/0 | 94.9 | 99.5 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00334 | 561 | 1718 | MDTE | 0/0 | 100.0 | 98.5 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00251 | 1083 | 1412 | MDTI | 0/0 | 100.0 | 99.7 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00251 | 731 | 1096 | MDTJ | 0/0 | 100.0 | 97.8 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00069 | 147 | 2198 | MDTO | 0/0 | 100.0 | 97.0 | MEG_3764 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTO | NA |
| contig00069 | 2195 | 3661 | MDTP | 0/0 | 100.0 | 96.5 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00976 | 728 | 1202 | MPHB | 0/0 | 99.6 | 97.0 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig01343 | 129 | 461 | MVRC | 0/0 | 100.0 | 91.6 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig00733 | 548 | 1417 | ROBA | 0/0 | 100.0 | 99.1 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig01022 | 129 | 451 | SOXS | 0/0 | 99.7 | 97.8 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00015 | 4966 | 5781 | SULII | 0/0 | 100.0 | 100.0 | MEG_6617 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| contig00757 | 1 | 1535 | YOGI | 0/0 | 93.4 | 97.5 | MEG_7842 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_ABC_efflux_pumps:YOGI | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00029 | 15382 | 16185 | aph(3’’)-Ib_5 | 0/0 | 100.0 | 100.0 | AF321551 | aph(3’’)-Ib | Streptomycin |
| contig00029 | 14546 | 15382 | aph(6)-Id_1 | 0/0 | 100.0 | 100.0 | M28829 | aph(6)-Id | Streptomycin |
| contig00029 | 12826 | 13299 | dfrA1_10 | 0/0 | 100.0 | 99.8 | AF203818 | dfrA1 | Trimethoprim |
| contig00307 | 4536 | 4958 | fosA7_1 | 0/0 | 100.0 | 94.1 | LAPJ01000014 | fosA7 | Fosfomycin |
| contig00019 | 7740 | 8972 | mdf(A)_1 | 0/0 | 100.0 | 98.5 | Y08743 | mdf(A) | |
| contig00029 | 10598 | 11464 | sul1_5 | 0/0 | 100.0 | 99.9 | EU780013 | sul1 | Sulfamethoxazole |
| contig00029 | 16246 | 17061 | sul2_3 | 0/0 | 100.0 | 100.0 | HQ840942 | sul2 | Sulfamethoxazole |
| contig00113 | 1749 | 2995 | tet(A)_6 | 0/0 | 97.8 | 100.0 | AF534183 | tet(A) | Doxycycline, Tetracycline |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00228 | 3904 | 7053 | acrB | 0/0 | 100.0 | 99.2 | U00096.3:484403-481253 | Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00158 | 5904 | 9017 | acrD | 0/0 | 100.0 | 99.0 | AP009048.1:2586250-2589364 | AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole and is regulated by baeRS and cpxAR. | aminoglycoside |
| contig00175 | 5122 | 8226 | acrF | 0/0 | 100.0 | 98.9 | U00096:3415032-3418137 | AcrF is a inner membrane transporter similar to AcrB. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00537 | 392 | 1054 | acrS | 0/0 | 100.0 | 98.8 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00029 | 15382 | 16185 | APH(3’’)-Ib | 0/0 | 100.0 | 99.8 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig00029 | 14546 | 15382 | APH(6)-Id | 0/0 | 100.0 | 99.9 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig00068 | 93 | 912 | bacA | 0/0 | 99.8 | 98.5 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00191 | 4487 | 5209 | baeR | 0/0 | 100.0 | 99.3 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00191 | 3087 | 4490 | baeS | 0/0 | 100.0 | 99.6 | AP009048:2165012-2166416 | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance. | aminocoumarin, aminoglycoside |
| contig00483 | 1368 | 2741 | cpxA | 0/0 | 100.0 | 98.7 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00297 | 2156 | 2788 | CRP | 0/0 | 100.0 | 99.5 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00029 | 12826 | 13299 | dfrA1 | 0/0 | 100.0 | 100.0 | KJ541681.1:19526-20000 | dfrA1 is an integron-encoded dihydrofolate reductase | diaminopyrimidine |
| contig00363 | 1 | 1150 | emrA | 0/0 | 98.0 | 98.5 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig00319 | 1 | 1531 | emrB | 0/0 | 99.5 | 99.8 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig00093 | 1345 | 2400 | emrK | 0/0 | 100.0 | 99.6 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00363 | 1277 | 1807 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00131 | 2495 | 4138 | eptA | 0/0 | 100.0 | 99.4 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00228 | 2688 | 3881 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.8 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00037 | 3213 | 4346 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.7 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00006 | 21474 | 22778 | Escherichia_coli_ampC1_beta-lactamase | 0/0 | 100.0 | 98.2 | FN649414.1:2765050-2766355 | An ampC-like beta-lactamase identified from Escherichia coli. | cephalosporin, penam |
| contig00119 | 4910 | 6067 | Escherichia_coli_ampH | 0/0 | 100.0 | 98.8 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00073 | 1397 | 1729 | Escherichia_coli_emrE | 0/0 | 100.0 | 98.8 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig00019 | 7740 | 8972 | Escherichia_coli_mdfA | 0/0 | 100.0 | 96.9 | JQ394987:0-1233 | Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter. | benzalkonium_chloride, rhodamine, tetracycline |
| contig00093 | 2924 | 3538 | evgA | 0/0 | 100.0 | 99.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00093 | 3543 | 7136 | evgS | 0/0 | 100.0 | 98.9 | U00096:2484373-2487967 | EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00307 | 4536 | 4958 | FosA7 | 0/0 | 100.0 | 94.1 | LAPJ01000014.1:36822-37245 | fosA7 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. | fosfomycin |
| contig00094 | 1568 | 2296 | gadW | 0/0 | 100.0 | 94.4 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00094 | 376 | 1200 | gadX | 0/0 | 100.0 | 97.9 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00282 | 5387 | 5800 | H-NS | 0/0 | 100.0 | 99.0 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00674 | 347 | 996 | kdpE | 0/0 | 95.9 | 97.2 | U00096.3:721733-721055 | kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding. | aminoglycoside |
| contig00219 | 5514 | 5897 | marA | 0/0 | 100.0 | 99.5 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00288 | 4317 | 5564 | mdtA | 0/0 | 100.0 | 98.0 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00288 | 1195 | 4317 | mdtB | 0/0 | 100.0 | 97.8 | U00096:2155262-2158385 | MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. | aminocoumarin |
| contig00094 | 5797 | 6954 | mdtE | 0/0 | 100.0 | 99.7 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00094 | 2659 | 5772 | mdtF | 0/0 | 100.0 | 98.6 | U00096:3660413-3663527 | MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex. | fluoroquinolone, macrolide, penam |
| contig00372 | 2316 | 3542 | mdtG | 0/0 | 100.0 | 99.2 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00066 | 9270 | 10478 | mdtH | 0/0 | 100.0 | 98.3 | U00096:1125326-1124117 | Multidrug resistance protein MdtH | fluoroquinolone |
| contig00070 | 1436 | 2668 | mdtM | 0/0 | 100.0 | 95.9 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00192 | 6643 | 7674 | mdtN | 0/0 | 100.0 | 98.1 | AP009048.1:4307588-4306556 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride. | acridine_dye, nucleoside |
| contig00192 | 4592 | 6643 | mdtO | 0/0 | 100.0 | 98.7 | AP009048.1:4306557-4304505 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00192 | 3129 | 4595 | mdtP | 0/0 | 100.0 | 98.2 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00033 | 4431 | 4905 | mphB | 0/0 | 99.6 | 97.5 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00008 | 15972 | 17720 | msbA | 0/0 | 100.0 | 99.0 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| contig00116 | 9184 | 10152 | pmrF | 0/0 | 100.0 | 99.7 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00029 | 10598 | 11437 | sul1 | 0/0 | 100.0 | 100.0 | JF969163:1053-1893 | Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons. | sulfonamide |
| contig00029 | 16246 | 17061 | sul2 | 0/0 | 100.0 | 99.6 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig00113 | 1749 | 2995 | tet(A) | 0/0 | 97.8 | 100.0 | AF534183.1:2970-4245 | TetA is a tetracycline efflux pump found in many species of Gram-negative bacteria. | tetracycline |
| contig00078 | 5917 | 7404 | tolC | 0/0 | 100.0 | 98.5 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| contig00324 | 1393 | 3036 | yojI | 0/0 | 100.0 | 98.2 | U00096.3:2308615-2306971 | YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00029 | 11942 | 12743 | (AGly)aadA1-pm | 0/0 | 96.5 | 99.9 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00029 | 15382 | 16185 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00029 | 14546 | 15382 | (AGly)strB | 0/0 | 100.0 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00006 | 21474 | 22778 | (Bla)AmpC1_Ecoli | 0/0 | 100.0 | 98.2 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00037 | 3213 | 4346 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 97.7 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00119 | 4910 | 6067 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 98.8 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00105 | 1015 | 2916 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100.0 | 99.4 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00307 | 4536 | 4958 | (Fcyn)FosA7 | 0/0 | 100.0 | 94.1 | LAPJ01000014:36823-37245 | (Fcyn)FosA7 | NA |
| contig00029 | 10598 | 11437 | (Sul)sul1 | 0/0 | 100.0 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig00029 | 16246 | 17061 | (Sul)sul2 | 0/0 | 100.0 | 99.6 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00113 | 1749 | 3023 | (Tet)tetA | 0/0 | 100.0 | 100.0 | JX424423:94438-95712 | (Tet)tetA | NA |
| contig00113 | 1068 | 1718 | (Tet)tetR | 0/0 | 100.0 | 100.0 | HF545434:53576-54226 | (Tet)tetR | NA |
| contig00029 | 12826 | 13299 | (Tmt)dfrA1 | 0/0 | 100.0 | 99.8 | JQ794607:474 | (Tmt)dfrA1 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00029 | 11942 | 12743 | (AGly)aadA1-pm | 0/0 | 96.5 | 99.9 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00029 | 15382 | 16185 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00029 | 14546 | 15382 | (AGly)strB | 0/0 | 100.0 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00006 | 21474 | 22778 | (Bla)AmpC1_Ecoli | 0/0 | 100.0 | 98.2 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00037 | 3213 | 4346 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 97.7 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00119 | 4910 | 6067 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 98.8 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00105 | 1015 | 2916 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100.0 | 99.4 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00307 | 4536 | 4958 | (Fcyn)FosA7 | 0/0 | 100.0 | 94.1 | LAPJ01000014:36823-37245 | (Fcyn)FosA7 | NA |
| contig00029 | 10598 | 11437 | (Sul)sul1 | 0/0 | 100.0 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig00029 | 16246 | 17061 | (Sul)sul2 | 0/0 | 100.0 | 99.6 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00113 | 1749 | 3023 | (Tet)tetA | 0/0 | 100.0 | 100.0 | JX424423:94438-95712 | (Tet)tetA | NA |
| contig00113 | 1068 | 1718 | (Tet)tetR | 0/0 | 100.0 | 100.0 | HF545434:53576-54226 | (Tet)tetR | NA |
| contig00029 | 12826 | 13299 | (Tmt)dfrA1 | 0/0 | 100.0 | 99.8 | JQ794607:474 | (Tmt)dfrA1 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00228 | 2688 | 3881 | ACRA | 0/0 | 100.0 | 99.8 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00228 | 3904 | 7053 | ACRB | 0/0 | 100.0 | 99.2 | MEG_401 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRB | NA |
| contig00158 | 5904 | 9017 | ACRD | 0/0 | 100.0 | 99.0 | MEG_407 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ACRD | NA |
| contig00175 | 5122 | 8226 | ACRF | 0/0 | 100.0 | 98.9 | MEG_409 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRF | NA |
| contig00537 | 392 | 1054 | ACRS | 0/0 | 100.0 | 98.8 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00119 | 4910 | 6067 | AMPH | 0/0 | 100.0 | 98.8 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00029 | 11942 | 12743 | ANT3-DPRIME | 0/0 | 96.5 | 99.9 | MEG_915 | Drugs:Aminoglycosides:Aminoglycoside_O-nucleotidyltransferases:ANT3-DPRIME | NA |
| contig00029 | 15382 | 16209 | APH3-DPRIME | 0/0 | 100.0 | 100.0 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00029 | 14546 | 15382 | APH6 | 0/0 | 100.0 | 100.0 | MEG_1086 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig00164 | 7396 | 9248 | ASMA | 0/0 | 100.0 | 98.3 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00068 | 93 | 912 | BACA | 0/0 | 99.8 | 98.8 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00191 | 4487 | 5209 | BAER | 0/0 | 100.0 | 99.3 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00191 | 3087 | 4490 | BAES | 0/0 | 100.0 | 99.6 | MEG_1193 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAES | NA |
| contig00275 | 1757 | 2947 | BCR | 0/0 | 100.0 | 98.2 | MEG_1210 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig00037 | 3213 | 4346 | BLAEC | 0/0 | 100.0 | 99.2 | MEG_1279 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00483 | 673 | 1371 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2122 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00483 | 1368 | 2741 | CPXAR | 0/0 | 100.0 | 99.4 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00297 | 2156 | 2788 | CRP | 0/0 | 100.0 | 99.5 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00029 | 12826 | 13299 | DFRA | 0/0 | 100.0 | 99.8 | MEG_2528 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00363 | 1 | 1150 | EMRA | 0/0 | 98.0 | 98.5 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig00319 | 1 | 1531 | EMRB | 0/0 | 99.5 | 99.8 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig00017 | 22477 | 23667 | EMRD | 0/0 | 100.0 | 99.9 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00093 | 1345 | 2508 | EMRK | 0/0 | 100.0 | 99.7 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00363 | 1277 | 1807 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00131 | 2495 | 4138 | EPTA | 0/0 | 100.0 | 99.4 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00093 | 3543 | 7136 | EVGS | 0/0 | 100.0 | 98.9 | MEG_2870 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EVGS | NA |
| contig00307 | 4536 | 4958 | FOSA | 0/0 | 100.0 | 94.1 | MEG_2988 | Drugs:Fosfomycin:Fosfomycin_thiol_transferases:FOSA | NA |
| contig00094 | 1568 | 2296 | GADW | 0/0 | 100.0 | 98.6 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00094 | 376 | 1200 | GADX | 0/0 | 100.0 | 97.9 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00282 | 5387 | 5800 | HNS | 0/0 | 100.0 | 99.0 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00674 | 347 | 996 | KDPE | 0/0 | 95.9 | 97.2 | MEG_3448 | Drugs:Aminoglycosides:Aminoglycoside_efflux_pumps:KDPE | NA |
| contig00219 | 5514 | 5903 | MARA | 0/0 | 100.0 | 99.5 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00219 | 5917 | 6351 | MARR | 0/0 | 100.0 | 97.7 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00019 | 7740 | 8972 | MDFA | 0/0 | 100.0 | 98.5 | MEG_3737 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDFA | NA |
| contig00288 | 4317 | 5564 | MDTA | 0/0 | 100.0 | 98.0 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00288 | 1195 | 4317 | MDTB | 0/0 | 100.0 | 97.8 | MEG_3747 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTB | NA |
| contig00094 | 5797 | 6954 | MDTE | 0/0 | 100.0 | 99.7 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00094 | 2659 | 5772 | MDTF | 0/0 | 100.0 | 98.6 | MEG_3752 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTF | NA |
| contig00372 | 2316 | 3542 | MDTG | 0/0 | 100.0 | 99.3 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00066 | 9270 | 10478 | MDTH | 0/0 | 100.0 | 98.3 | MEG_3755 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTH | NA |
| contig00420 | 3167 | 3486 | MDTI | 0/0 | 97.0 | 99.4 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00122 | 9933 | 11174 | MDTK | 0/0 | 90.4 | 99.2 | MEG_3759 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MATE_efflux_pumps:MDTK | NA |
| contig00070 | 1436 | 2668 | MDTM | 0/0 | 100.0 | 95.9 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00192 | 6643 | 7674 | MDTN | 0/0 | 100.0 | 98.1 | MEG_3763 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTN | NA |
| contig00192 | 4592 | 6643 | MDTO | 0/0 | 100.0 | 98.7 | MEG_3764 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTO | NA |
| contig00192 | 3129 | 4595 | MDTP | 0/0 | 100.0 | 98.2 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00033 | 4431 | 4905 | MPHB | 0/0 | 99.6 | 97.5 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00008 | 15972 | 17720 | MSBA | 0/0 | 100.0 | 99.0 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
| contig00073 | 1397 | 1729 | MVRC | 0/0 | 100.0 | 98.8 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig00105 | 1015 | 2916 | PBP2 | 0/0 | 100.0 | 99.4 | MEG_5400 | Drugs:betalactams:Penicillin_binding_protein:PBP2 | NA |
| contig00006 | 21474 | 22778 | PBP4B | 0/0 | 100.0 | 98.2 | MEG_5409 | Drugs:betalactams:Penicillin_binding_protein:PBP4B | NA |
| contig00116 | 9184 | 10152 | PMRF | 0/0 | 100.0 | 99.7 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00060 | 11897 | 12766 | ROBA | 0/0 | 100.0 | 99.2 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00411 | 1934 | 2257 | SOXS | 0/0 | 100.0 | 100.0 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00029 | 10471 | 11438 | SULI | 0/0 | 100.0 | 100.0 | MEG_6615 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULI | NA |
| contig00029 | 16246 | 17061 | SULII | 0/0 | 100.0 | 100.0 | MEG_6618 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| contig00113 | 1749 | 3023 | TETA | 0/0 | 100.0 | 100.0 | MEG_7024 | Drugs:Tetracyclines:Tetracycline_resistance_MFS_efflux_pumps:TETA | NA |
| contig00324 | 1393 | 3036 | YOGI | 0/0 | 100.0 | 98.2 | MEG_7842 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_ABC_efflux_pumps:YOGI | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00024 | 7677 | 8480 | aph(3’’)-Ib_5 | 0/0 | 100 | 100.0 | AF321551 | aph(3’’)-Ib | Streptomycin |
| contig00024 | 6841 | 7677 | aph(6)-Id_1 | 0/0 | 100 | 99.9 | M28829 | aph(6)-Id | Streptomycin |
| contig00935 | 575 | 1435 | blaTEM-1B_1 | 0/0 | 100 | 100.0 | AY458016 | blaTEM-1B | Amoxicillin, Ampicillin, Cephalothin, Piperacillin, Ticarcillin |
| contig01210 | 42 | 551 | dfrA8_1 | 0/0 | 100 | 100.0 | U10186 | dfrA8 | Trimethoprim |
| contig00024 | 1383 | 2304 | mph(A)_2 | 1/1 | 100 | 99.6 | U36578 | mph(A) | Erythromycin, Azithromycin, Spiramycin, Telithromycin |
| contig00024 | 8541 | 9356 | sul2_2 | 0/0 | 100 | 100.0 | AY034138 | sul2 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00005 | 2457 | 5606 | acrB | 0/0 | 100.0 | 100.0 | U00096.3:484403-481253 | Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00024 | 7677 | 8480 | APH(3’’)-Ib | 0/0 | 100.0 | 99.8 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig00024 | 6841 | 7677 | APH(6)-Id | 0/0 | 100.0 | 99.8 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig00039 | 5548 | 6270 | baeR | 0/0 | 100.0 | 100.0 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00039 | 4148 | 5551 | baeS | 0/0 | 100.0 | 100.0 | AP009048:2165012-2166416 | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance. | aminocoumarin, aminoglycoside |
| contig00643 | 1037 | 2410 | cpxA | 0/0 | 100.0 | 99.0 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00305 | 566 | 1198 | CRP | 0/0 | 100.0 | 99.8 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig01210 | 42 | 551 | dfrA8 | 0/0 | 100.0 | 100.0 | KJ174469:710-1220 | dfrA8 is a transposon-encoded dihydrofolate reductase found in Salmonella enterica | diaminopyrimidine |
| contig00412 | 2249 | 3308 | emrA | 0/0 | 90.4 | 100.0 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig00412 | 694 | 2232 | emrB | 0/0 | 100.0 | 100.0 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig00705 | 386 | 1441 | emrK | 0/0 | 100.0 | 99.9 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00276 | 1167 | 2810 | eptA | 0/0 | 100.0 | 100.0 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00005 | 1241 | 2434 | Escherichia_coli_acrA | 0/0 | 100.0 | 100.0 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00277 | 2915 | 4048 | Escherichia_coli_ampC | 0/0 | 100.0 | 100.0 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00131 | 4387 | 5691 | Escherichia_coli_ampC1_beta-lactamase | 0/0 | 100.0 | 100.0 | FN649414.1:2765050-2766355 | An ampC-like beta-lactamase identified from Escherichia coli. | cephalosporin, penam |
| contig00363 | 1586 | 2314 | gadW | 0/0 | 100.0 | 94.5 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00363 | 394 | 1218 | gadX | 0/0 | 100.0 | 100.0 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00040 | 3528 | 3941 | H-NS | 0/0 | 100.0 | 99.3 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00461 | 1226 | 2383 | mdtE | 0/0 | 100.0 | 100.0 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00570 | 731 | 1957 | mdtG | 0/0 | 100.0 | 99.7 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00168 | 1239 | 2447 | mdtH | 0/0 | 100.0 | 98.8 | U00096:1125326-1124117 | Multidrug resistance protein MdtH | fluoroquinolone |
| contig00798 | 481 | 1713 | mdtM | 0/0 | 100.0 | 96.3 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00054 | 6565 | 7596 | mdtN | 0/0 | 100.0 | 99.9 | AP009048.1:4307588-4306556 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride. | acridine_dye, nucleoside |
| contig00054 | 3129 | 4595 | mdtP | 0/0 | 100.0 | 100.0 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00024 | 1383 | 2288 | mphA | 0/0 | 100.0 | 99.9 | D16251.1:2531-1625 | The mphA gene encodes for resistance enzyme MPH(2’)-I which preferentially inactivate 14-membered macrolides (e.g.erythromycin telithromycin roxithromycin) over 16-membered macrolides (e.g.tylosin spiramycin). It phosphorylates macrolides at 2’-OH hydroxyl of desosamine sugar of macrolides in a GTP-dependent manner. | macrolide |
| contig00230 | 1699 | 2175 | mphB | 0/0 | 100.0 | 98.1 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00004 | 3126 | 4874 | msbA | 0/0 | 100.0 | 100.0 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| contig00024 | 8541 | 9356 | sul2 | 0/0 | 100.0 | 100.0 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig00935 | 575 | 1435 | TEM-1 | 0/0 | 100.0 | 99.9 | AL513383:161910-162771 | TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. | cephalosporin, monobactam, penam, penem |
| contig00021 | 5667 | 7154 | tolC | 0/0 | 100.0 | 99.9 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| contig00617 | 934 | 2517 | yojI | 0/0 | 96.3 | 99.9 | U00096.3:2308615-2306971 | YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00024 | 7677 | 8480 | (AGly)strA | 0/0 | 100 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00024 | 6841 | 7677 | (AGly)strB | 0/0 | 100 | 99.9 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00131 | 4387 | 5691 | (Bla)AmpC1_Ecoli | 0/0 | 100 | 100.0 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00277 | 2915 | 4048 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 100.0 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00935 | 575 | 1435 | (Bla)blaTEM-105 | 0/0 | 100 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00024 | 1383 | 2288 | (MLS)mph(A) | 0/0 | 100 | 99.9 | DQ445270:1626-2531 | (MLS)mph(A) | NA |
| contig00024 | 8541 | 9356 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig01210 | 42 | 551 | (Tmt)dfrA8 | 0/0 | 100 | 100.0 | U10186:711-1220 | (Tmt)dfrA8 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00024 | 7677 | 8480 | (AGly)strA | 0/0 | 100 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00024 | 6841 | 7677 | (AGly)strB | 0/0 | 100 | 99.9 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00131 | 4387 | 5691 | (Bla)AmpC1_Ecoli | 0/0 | 100 | 100.0 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00277 | 2915 | 4048 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 100.0 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00935 | 575 | 1435 | (Bla)blaTEM-105 | 0/0 | 100 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00024 | 1383 | 2288 | (MLS)mph(A) | 0/0 | 100 | 99.9 | DQ445270:1626-2531 | (MLS)mph(A) | NA |
| contig00024 | 8541 | 9356 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig01210 | 42 | 551 | (Tmt)dfrA8 | 0/0 | 100 | 100.0 | U10186:711-1220 | (Tmt)dfrA8 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00005 | 1241 | 2434 | ACRA | 0/0 | 100.0 | 100.0 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00005 | 2457 | 5606 | ACRB | 0/0 | 100.0 | 100.0 | MEG_401 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRB | NA |
| contig00277 | 2915 | 4048 | AMPC | 0/0 | 100.0 | 100.0 | MEG_728 | Drugs:betalactams:Class_C_betalactamases:AMPC | NA |
| contig00024 | 7677 | 8504 | APH3-DPRIME | 0/0 | 100.0 | 100.0 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00024 | 6841 | 7677 | APH6 | 0/0 | 100.0 | 100.0 | MEG_1084 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig00039 | 5548 | 6270 | BAER | 0/0 | 100.0 | 100.0 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00039 | 4148 | 5551 | BAES | 0/0 | 100.0 | 100.0 | MEG_1193 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAES | NA |
| contig00643 | 342 | 1040 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2122 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00643 | 1037 | 2410 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00305 | 566 | 1198 | CRP | 0/0 | 100.0 | 99.8 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig01210 | 42 | 551 | DFRA | 0/0 | 100.0 | 100.0 | MEG_2553 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00412 | 2249 | 3308 | EMRA | 0/0 | 90.4 | 100.0 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig00412 | 694 | 2232 | EMRB | 0/0 | 100.0 | 100.0 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig00013 | 164 | 1354 | EMRD | 0/0 | 100.0 | 100.0 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00705 | 386 | 1549 | EMRK | 0/0 | 100.0 | 99.9 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00276 | 1167 | 2810 | EPTA | 0/0 | 100.0 | 100.0 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00363 | 1586 | 2314 | GADW | 0/0 | 100.0 | 99.9 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00363 | 394 | 1218 | GADX | 0/0 | 100.0 | 100.0 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00040 | 3528 | 3941 | HNS | 0/0 | 100.0 | 99.3 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00400 | 2837 | 3271 | MARR | 0/0 | 100.0 | 100.0 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00461 | 1226 | 2383 | MDTE | 0/0 | 100.0 | 100.0 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00570 | 731 | 1957 | MDTG | 0/0 | 100.0 | 99.7 | MEG_3754 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00168 | 1239 | 2447 | MDTH | 0/0 | 100.0 | 98.8 | MEG_3755 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTH | NA |
| contig00901 | 380 | 709 | MDTI | 0/0 | 100.0 | 100.0 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00901 | 28 | 393 | MDTJ | 0/0 | 100.0 | 99.5 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00798 | 481 | 1713 | MDTM | 0/0 | 100.0 | 96.3 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00054 | 6565 | 7596 | MDTN | 0/0 | 100.0 | 99.9 | MEG_3763 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTN | NA |
| contig00054 | 3129 | 4595 | MDTP | 0/0 | 100.0 | 100.0 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00024 | 1383 | 2304 | MPHA | 1/1 | 100.0 | 99.6 | MEG_4030 | Drugs:MLS:Macrolide_phosphotransferases:MPHA | NA |
| contig00230 | 1699 | 2175 | MPHB | 0/0 | 100.0 | 98.1 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00004 | 3126 | 4874 | MSBA | 0/0 | 100.0 | 100.0 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
| contig00131 | 4387 | 5691 | PBP4B | 0/0 | 100.0 | 100.0 | MEG_5409 | Drugs:betalactams:Penicillin_binding_protein:PBP4B | NA |
| contig00840 | 1554 | 1870 | SOXS | 0/0 | 97.8 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00024 | 8541 | 9356 | SULII | 0/0 | 100.0 | 100.0 | MEG_6617 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| contig00617 | 934 | 2517 | YOGI | 0/0 | 96.3 | 99.9 | MEG_7842 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_ABC_efflux_pumps:YOGI | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00753 | 119 | 922 | aph(3’’)-Ib_5 | 0/0 | 100.0 | 100.0 | AF321551 | aph(3’’)-Ib | Streptomycin |
| contig01741 | 1 | 839 | blaTEM-1B_1 | 0/0 | 97.4 | 100.0 | AY458016 | blaTEM-1B | Amoxicillin, Ampicillin, Cephalothin, Piperacillin, Ticarcillin |
| contig00681 | 764 | 1337 | dfrA7_5 | 3/4 | 100.0 | 98.8 | AJ419170 | dfrA7 | Trimethoprim |
| contig00295 | 558 | 1790 | mdf(A)_1 | 0/0 | 100.0 | 97.6 | Y08743 | mdf(A) | |
| contig00753 | 983 | 1798 | sul2_3 | 0/0 | 100.0 | 100.0 | HQ840942 | sul2 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01035 | 197 | 1354 | acrE | 0/0 | 100.0 | 98.8 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00753 | 119 | 922 | APH(3’’)-Ib | 0/0 | 100.0 | 99.8 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig00021 | 41 | 860 | bacA | 0/0 | 99.8 | 97.6 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig01020 | 843 | 1564 | baeR | 0/0 | 99.9 | 97.8 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00545 | 1117 | 2490 | cpxA | 0/0 | 100.0 | 97.8 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig01089 | 878 | 1475 | CRP | 0/0 | 94.5 | 99.0 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00681 | 864 | 1337 | dfrA7 | 0/0 | 100.0 | 100.0 | FJ854362:2338-2812 | dfrA7 is an integron-encoded dihydrofolate reductase found in Escherichia coli | diaminopyrimidine |
| contig00627 | 136 | 1674 | emrB | 0/0 | 100.0 | 98.2 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig00788 | 899 | 1954 | emrK | 0/0 | 100.0 | 97.0 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig01310 | 71 | 601 | emrR | 0/0 | 100.0 | 99.4 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00112 | 1141 | 2784 | eptA | 0/0 | 100.0 | 98.1 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig01099 | 64 | 1257 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.0 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00033 | 3096 | 4229 | Escherichia_coli_ampC | 0/0 | 100.0 | 98.0 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00295 | 558 | 1790 | Escherichia_coli_mdfA | 0/0 | 100.0 | 96.0 | JQ394987:0-1233 | Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter. | benzalkonium_chloride, rhodamine, tetracycline |
| contig00773 | 344 | 958 | evgA | 0/0 | 100.0 | 99.2 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00716 | 1 | 701 | gadW | 0/0 | 96.2 | 95.7 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig01401 | 192 | 1016 | gadX | 0/0 | 100.0 | 96.8 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00109 | 1021 | 1404 | marA | 0/0 | 100.0 | 99.7 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00277 | 154 | 1401 | mdtA | 0/0 | 100.0 | 97.4 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00331 | 1 | 3040 | mdtC | 0/0 | 98.8 | 96.8 | U00096:2158385-2161463 | MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58. | aminocoumarin |
| contig01054 | 403 | 1535 | mdtE | 0/0 | 97.8 | 98.5 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00494 | 718 | 1944 | mdtG | 0/0 | 100.0 | 98.0 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00378 | 427 | 2175 | msbA | 0/0 | 100.0 | 98.8 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| contig00402 | 754 | 1722 | pmrF | 0/0 | 100.0 | 98.0 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00753 | 983 | 1798 | sul2 | 0/0 | 100.0 | 99.6 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig01741 | 1 | 839 | TEM-1 | 0/0 | 97.4 | 99.9 | AL513383:161910-162771 | TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. | cephalosporin, monobactam, penam, penem |
| contig00251 | 1617 | 3104 | tolC | 0/0 | 100.0 | 98.5 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| contig00824 | 78 | 1244 | ugd | 0/0 | 100.0 | 99.8 | U00096:2099613-2098446 | PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00753 | 119 | 922 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00033 | 3096 | 4229 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 98.0 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig01741 | 1 | 839 | (Bla)blaTEM-105 | 0/0 | 97.4 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00753 | 983 | 1798 | (Sul)sul2 | 0/0 | 100.0 | 99.6 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig01082 | 454 | 1104 | (Tet)tetR | 0/0 | 100.0 | 100.0 | HF545434:53576-54226 | (Tet)tetR | NA |
| contig00681 | 864 | 1337 | (Tmt)dhfr7 | 0/0 | 100.0 | 100.0 | X58425:594-1067 | (Tmt)dhfr7 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00753 | 119 | 922 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00033 | 3096 | 4229 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 98.0 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig01741 | 1 | 839 | (Bla)blaTEM-105 | 0/0 | 97.4 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00753 | 983 | 1798 | (Sul)sul2 | 0/0 | 100.0 | 99.6 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig01082 | 454 | 1104 | (Tet)tetR | 0/0 | 100.0 | 100.0 | HF545434:53576-54226 | (Tet)tetR | NA |
| contig00681 | 864 | 1337 | (Tmt)dhfr7 | 0/0 | 100.0 | 100.0 | X58425:594-1067 | (Tmt)dhfr7 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01099 | 64 | 1257 | ACRA | 0/0 | 100.0 | 99.0 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig01035 | 197 | 1354 | ACRE | 0/0 | 100.0 | 98.8 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig00753 | 119 | 946 | APH3-DPRIME | 0/0 | 100.0 | 100.0 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00021 | 41 | 860 | BACA | 0/0 | 99.8 | 97.6 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig01020 | 843 | 1564 | BAER | 0/0 | 99.9 | 97.8 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00033 | 3096 | 4229 | BLAEC | 0/0 | 100.0 | 98.2 | MEG_1278 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00545 | 422 | 1120 | CPXAR | 0/0 | 100.0 | 99.6 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00545 | 1117 | 2490 | CPXAR | 0/0 | 100.0 | 98.1 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig01089 | 878 | 1475 | CRP | 0/0 | 94.5 | 99.0 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00681 | 864 | 1337 | DFRA | 0/0 | 100.0 | 100.0 | MEG_2548 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00627 | 136 | 1674 | EMRB | 0/0 | 100.0 | 98.2 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig00788 | 899 | 1984 | EMRK | 0/0 | 93.3 | 97.0 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig01310 | 71 | 601 | EMRR | 0/0 | 100.0 | 99.4 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00112 | 1141 | 2784 | EPTA | 0/0 | 100.0 | 98.1 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00716 | 1 | 701 | GADW | 0/0 | 96.2 | 97.4 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig01401 | 192 | 1016 | GADX | 0/0 | 100.0 | 96.8 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00109 | 1015 | 1404 | MARA | 0/0 | 100.0 | 99.7 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00109 | 567 | 1001 | MARR | 0/0 | 100.0 | 98.4 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00295 | 558 | 1790 | MDFA | 0/0 | 100.0 | 97.7 | MEG_3737 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDFA | NA |
| contig00277 | 154 | 1401 | MDTA | 0/0 | 100.0 | 97.4 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00331 | 1 | 3040 | MDTC | 0/0 | 98.8 | 96.8 | MEG_3749 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTC | NA |
| contig01054 | 403 | 1535 | MDTE | 0/0 | 97.8 | 98.5 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00494 | 718 | 1944 | MDTG | 0/0 | 100.0 | 98.2 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00380 | 2576 | 2905 | MDTI | 0/0 | 100.0 | 99.7 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00206 | 1709 | 3081 | MDTK | 0/0 | 99.9 | 98.7 | MEG_3759 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MATE_efflux_pumps:MDTK | NA |
| contig00378 | 427 | 2175 | MSBA | 0/0 | 100.0 | 98.8 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
| contig00402 | 754 | 1722 | PMRF | 0/0 | 100.0 | 98.0 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00741 | 1207 | 2076 | ROBA | 0/0 | 100.0 | 99.3 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00753 | 983 | 1798 | SULII | 0/0 | 100.0 | 100.0 | MEG_6618 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| contig00824 | 78 | 1244 | UGD | 0/0 | 100.0 | 99.8 | MEG_7328 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:UGD | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00010 | 3746 | 4549 | aph(3’’)-Ib_5 | 0/0 | 100 | 100.0 | AF321551 | aph(3’’)-Ib | Streptomycin |
| contig00010 | 2910 | 3746 | aph(6)-Id_1 | 0/0 | 100 | 99.9 | M28829 | aph(6)-Id | Streptomycin |
| contig00291 | 575 | 1435 | blaTEM-1B_1 | 0/0 | 100 | 100.0 | AY458016 | blaTEM-1B | Amoxicillin, Ampicillin, Cephalothin, Piperacillin, Ticarcillin |
| contig01148 | 43 | 552 | dfrA8_1 | 0/0 | 100 | 100.0 | U10186 | dfrA8 | Trimethoprim |
| contig00010 | 4610 | 5425 | sul2_2 | 0/0 | 100 | 100.0 | AY034138 | sul2 | Sulfamethoxazole |
| contig00489 | 742 | 1947 | tet(B)_2 | 0/0 | 100 | 100.0 | AF326777 | tet(B) | Doxycycline, Tetracycline, Minocycline |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00282 | 1233 | 2390 | acrE | 0/0 | 100.0 | 99.0 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00010 | 3746 | 4549 | APH(3’’)-Ib | 0/0 | 100.0 | 99.8 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig00010 | 2910 | 3746 | APH(6)-Id | 0/0 | 100.0 | 99.8 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig01472 | 115 | 936 | bacA | 0/0 | 100.0 | 99.5 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00392 | 909 | 1631 | baeR | 0/0 | 100.0 | 100.0 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00060 | 2600 | 3973 | cpxA | 0/0 | 100.0 | 99.0 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00030 | 916 | 1548 | CRP | 0/0 | 100.0 | 99.8 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig01148 | 43 | 552 | dfrA8 | 0/0 | 100.0 | 100.0 | KJ174469:710-1220 | dfrA8 is a transposon-encoded dihydrofolate reductase found in Salmonella enterica | diaminopyrimidine |
| contig00673 | 515 | 1570 | emrK | 0/0 | 100.0 | 99.9 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig01023 | 218 | 1298 | Escherichia_coli_acrA | 0/0 | 90.5 | 99.9 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00003 | 6574 | 7707 | Escherichia_coli_ampC | 0/0 | 100.0 | 98.2 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00473 | 617 | 949 | Escherichia_coli_emrE | 0/0 | 100.0 | 92.2 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig00314 | 1 | 1212 | mdtA | 0/0 | 97.1 | 99.5 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00503 | 89 | 1246 | mdtE | 0/0 | 100.0 | 100.0 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00131 | 1287 | 2513 | mdtG | 0/0 | 100.0 | 99.3 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00200 | 532 | 1764 | mdtM | 0/0 | 100.0 | 97.3 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00010 | 4610 | 5425 | sul2 | 0/0 | 100.0 | 100.0 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig00291 | 575 | 1435 | TEM-1 | 0/0 | 100.0 | 99.9 | AL513383:161910-162771 | TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. | cephalosporin, monobactam, penam, penem |
| contig00489 | 742 | 1947 | tet(B) | 0/0 | 100.0 | 99.8 | AB089595:0-1206 | Tet(B) is a tetracycline efflux protein expressed in many Gram-negative bacteria. It confers resistance to tetracycline doxycycline and minocycline but not tigecycline. | tetracycline |
| contig00888 | 1 | 1443 | tolC | 0/0 | 97.0 | 99.7 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00010 | 3746 | 4549 | (AGly)strA | 0/0 | 100 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00010 | 2910 | 3746 | (AGly)strB | 0/0 | 100 | 99.9 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00003 | 6574 | 7707 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 98.2 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00291 | 575 | 1435 | (Bla)blaTEM-105 | 0/0 | 100 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00063 | 839 | 2740 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 99.0 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00010 | 4610 | 5425 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00489 | 742 | 1947 | (Tet)tetB | 0/0 | 100 | 99.7 | AB089594:1-1206 | (Tet)tetB | NA |
| contig01148 | 43 | 552 | (Tmt)dfrA8 | 0/0 | 100 | 100.0 | U10186:711-1220 | (Tmt)dfrA8 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00010 | 3746 | 4549 | (AGly)strA | 0/0 | 100 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00010 | 2910 | 3746 | (AGly)strB | 0/0 | 100 | 99.9 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00003 | 6574 | 7707 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 98.2 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00291 | 575 | 1435 | (Bla)blaTEM-105 | 0/0 | 100 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00063 | 839 | 2740 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 99.0 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00010 | 4610 | 5425 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00489 | 742 | 1947 | (Tet)tetB | 0/0 | 100 | 99.7 | AB089594:1-1206 | (Tet)tetB | NA |
| contig01148 | 43 | 552 | (Tmt)dfrA8 | 0/0 | 100 | 100.0 | U10186:711-1220 | (Tmt)dfrA8 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01023 | 218 | 1298 | ACRA | 0/0 | 90.5 | 99.9 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00282 | 1233 | 2390 | ACRE | 0/0 | 100.0 | 99.0 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig00010 | 3746 | 4573 | APH3-DPRIME | 0/0 | 100.0 | 100.0 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00010 | 2910 | 3746 | APH6 | 0/0 | 100.0 | 100.0 | MEG_1084 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig01472 | 115 | 936 | BACA | 0/0 | 100.0 | 99.5 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00392 | 909 | 1631 | BAER | 0/0 | 100.0 | 100.0 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00003 | 6574 | 7707 | BLAEC | 0/0 | 100.0 | 99.7 | MEG_1276 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00060 | 1905 | 2603 | CPXAR | 0/0 | 100.0 | 99.9 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00060 | 2600 | 3973 | CPXAR | 0/0 | 100.0 | 99.8 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00030 | 916 | 1548 | CRP | 0/0 | 100.0 | 99.8 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig01148 | 43 | 552 | DFRA | 0/0 | 100.0 | 100.0 | MEG_2553 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig01048 | 1 | 1093 | EMRD | 0/0 | 91.8 | 100.0 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00673 | 515 | 1655 | EMRK | 0/0 | 98.0 | 99.9 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00314 | 1 | 1212 | MDTA | 0/0 | 97.1 | 99.5 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00503 | 89 | 1246 | MDTE | 0/0 | 100.0 | 100.0 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00131 | 1287 | 2513 | MDTG | 0/0 | 100.0 | 99.8 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig02237 | 200 | 529 | MDTI | 0/0 | 100.0 | 99.7 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00200 | 532 | 1764 | MDTM | 0/0 | 100.0 | 97.3 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00473 | 617 | 949 | MVRC | 0/0 | 100.0 | 92.2 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig00063 | 839 | 2740 | PBP2 | 0/0 | 100.0 | 99.0 | MEG_5400 | Drugs:betalactams:Penicillin_binding_protein:PBP2 | NA |
| contig00048 | 3214 | 4083 | ROBA | 0/0 | 100.0 | 100.0 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00010 | 4610 | 5425 | SULII | 0/0 | 100.0 | 100.0 | MEG_6617 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| contig00489 | 742 | 1947 | TETB | 0/0 | 100.0 | 100.0 | MEG_7052 | Drugs:Tetracyclines:Tetracycline_resistance_MFS_efflux_pumps:TETB | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01332 | 257 | 1117 | blaTEM-1B_1 | 0/0 | 100 | 100.0 | AY458016 | blaTEM-1B | Amoxicillin, Ampicillin, Cephalothin, Piperacillin, Ticarcillin |
| contig01365 | 467 | 1040 | dfrA7_5 | 3/4 | 100 | 98.8 | AJ419170 | dfrA7 | Trimethoprim |
| contig00837 | 778 | 1593 | sul2_3 | 0/0 | 100 | 100.0 | HQ840942 | sul2 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01835 | 1 | 773 | bacA | 0/0 | 94.0 | 100.0 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00394 | 1117 | 2490 | cpxA | 0/0 | 100.0 | 99.0 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00092 | 445 | 1077 | CRP | 0/0 | 100.0 | 99.8 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig01365 | 567 | 1040 | dfrA7 | 0/0 | 100.0 | 100.0 | FJ854362:2338-2812 | dfrA7 is an integron-encoded dihydrofolate reductase found in Escherichia coli | diaminopyrimidine |
| contig00069 | 2755 | 3927 | emrA | 0/0 | 100.0 | 100.0 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig00069 | 1200 | 2738 | emrB | 0/0 | 100.0 | 100.0 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig00990 | 342 | 1397 | emrK | 0/0 | 100.0 | 100.0 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00069 | 4054 | 4584 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00098 | 2245 | 3888 | eptA | 0/0 | 100.0 | 100.0 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00359 | 535 | 1728 | Escherichia_coli_acrA | 0/0 | 100.0 | 100.0 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00025 | 3715 | 4848 | Escherichia_coli_ampC | 0/0 | 100.0 | 100.0 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00684 | 399 | 1556 | Escherichia_coli_ampH | 0/0 | 100.0 | 100.0 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig01558 | 25 | 639 | evgA | 0/0 | 100.0 | 100.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00270 | 1 | 718 | gadW | 0/0 | 98.5 | 94.7 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig01283 | 371 | 1195 | gadX | 0/0 | 100.0 | 100.0 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00074 | 4084 | 4497 | H-NS | 0/0 | 100.0 | 99.3 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00108 | 2588 | 2971 | marA | 0/0 | 100.0 | 100.0 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig01407 | 1 | 1104 | mdtE | 0/0 | 95.3 | 100.0 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00229 | 1145 | 2371 | mdtG | 0/0 | 100.0 | 99.4 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00065 | 919 | 2385 | mdtP | 0/0 | 100.0 | 100.0 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00222 | 1329 | 1805 | mphB | 0/0 | 100.0 | 98.3 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00837 | 778 | 1593 | sul2 | 0/0 | 100.0 | 99.6 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig01332 | 257 | 1117 | TEM-1 | 0/0 | 100.0 | 99.9 | AL513383:161910-162771 | TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. | cephalosporin, monobactam, penam, penem |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00025 | 3715 | 4848 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 100.0 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00684 | 399 | 1556 | (Bla)ampH_Ecoli | 0/0 | 100 | 100.0 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig01332 | 257 | 1117 | (Bla)blaTEM-105 | 0/0 | 100 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00837 | 778 | 1593 | (Sul)sul2 | 0/0 | 100 | 99.6 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig01365 | 567 | 1040 | (Tmt)dhfr7 | 0/0 | 100 | 100.0 | X58425:594-1067 | (Tmt)dhfr7 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00025 | 3715 | 4848 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 100.0 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00684 | 399 | 1556 | (Bla)ampH_Ecoli | 0/0 | 100 | 100.0 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig01332 | 257 | 1117 | (Bla)blaTEM-105 | 0/0 | 100 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00837 | 778 | 1593 | (Sul)sul2 | 0/0 | 100 | 99.6 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig01365 | 567 | 1040 | (Tmt)dhfr7 | 0/0 | 100 | 100.0 | X58425:594-1067 | (Tmt)dhfr7 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00359 | 535 | 1728 | ACRA | 0/0 | 100.0 | 100.0 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00025 | 3715 | 4848 | AMPC | 0/0 | 100.0 | 100.0 | MEG_728 | Drugs:betalactams:Class_C_betalactamases:AMPC | NA |
| contig00684 | 399 | 1556 | AMPH | 0/0 | 100.0 | 100.0 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig01835 | 1 | 773 | BACA | 0/0 | 94.0 | 100.0 | MEG_1190 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00394 | 422 | 1120 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2122 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00394 | 1117 | 2490 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00092 | 445 | 1077 | CRP | 0/0 | 100.0 | 99.8 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig01365 | 567 | 1040 | DFRA | 0/0 | 100.0 | 100.0 | MEG_2548 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00069 | 2755 | 3927 | EMRA | 0/0 | 100.0 | 100.0 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig00069 | 1200 | 2738 | EMRB | 0/0 | 100.0 | 100.0 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig00990 | 342 | 1471 | EMRK | 0/0 | 97.1 | 100.0 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00069 | 4054 | 4584 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00098 | 2245 | 3888 | EPTA | 0/0 | 100.0 | 100.0 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00270 | 1 | 718 | GADW | 0/0 | 98.5 | 100.0 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig01283 | 371 | 1195 | GADX | 0/0 | 100.0 | 100.0 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00074 | 4084 | 4497 | HNS | 0/0 | 100.0 | 99.3 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00108 | 2582 | 2971 | MARA | 0/0 | 100.0 | 100.0 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00108 | 2134 | 2568 | MARR | 0/0 | 100.0 | 100.0 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig01407 | 1 | 1104 | MDTE | 0/0 | 95.3 | 100.0 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00229 | 1145 | 2371 | MDTG | 0/0 | 100.0 | 100.0 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00861 | 1 | 324 | MDTI | 0/0 | 98.2 | 100.0 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00561 | 251 | 1624 | MDTK | 0/0 | 100.0 | 100.0 | MEG_3759 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MATE_efflux_pumps:MDTK | NA |
| contig00065 | 919 | 2385 | MDTP | 0/0 | 100.0 | 100.0 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00222 | 1329 | 1805 | MPHB | 0/0 | 100.0 | 98.3 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00289 | 1516 | 1839 | SOXS | 0/0 | 100.0 | 100.0 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00837 | 778 | 1593 | SULII | 0/0 | 100.0 | 100.0 | MEG_6618 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01083 | 173 | 655 | dfrA14_5 | 0/0 | 100 | 99.6 | DQ388123 | dfrA14 | Trimethoprim |
| contig00834 | 192 | 1007 | sul2_2 | 0/0 | 100 | 100.0 | AY034138 | sul2 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00026 | 2130 | 2792 | acrS | 0/0 | 100.0 | 98.9 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00657 | 400 | 1173 | bacA | 0/0 | 94.2 | 99.0 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig01083 | 173 | 655 | dfrA14 | 0/0 | 100.0 | 99.8 | EU780012:2162-2645 | dfrA14 is an integron-encoded dihydrofolate reductase found in Escherichia coli | diaminopyrimidine |
| contig00546 | 278 | 1275 | emrK | 0/0 | 94.5 | 99.9 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00024 | 517 | 2160 | eptA | 0/0 | 100.0 | 100.0 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00207 | 7 | 1755 | msbA | 0/0 | 100.0 | 100.0 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| contig00683 | 159 | 1127 | pmrF | 0/0 | 100.0 | 100.0 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00834 | 192 | 1007 | sul2 | 0/0 | 100.0 | 100.0 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00834 | 192 | 1007 | (Sul)sul2 | 0/0 | 100 | 100 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig01083 | 173 | 646 | (Tmt)dfrA14 | 0/0 | 100 | 100 | GU726917:72-545 | (Tmt)dfrA14 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00834 | 192 | 1007 | (Sul)sul2 | 0/0 | 100 | 100 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig01083 | 173 | 646 | (Tmt)dfrA14 | 0/0 | 100 | 100 | GU726917:72-545 | (Tmt)dfrA14 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00026 | 2130 | 2792 | ACRS | 0/0 | 100.0 | 98.9 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00657 | 400 | 1173 | BACA | 0/0 | 94.2 | 99.0 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig01083 | 173 | 646 | DFRA | 0/0 | 100.0 | 99.8 | MEG_2517 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00024 | 517 | 2160 | EPTA | 0/0 | 100.0 | 100.0 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig01274 | 422 | 855 | MARR | 0/0 | 99.8 | 100.0 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig02042 | 245 | 610 | MDTJ | 0/0 | 100.0 | 99.2 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00129 | 1 | 1242 | MDTK | 0/0 | 90.4 | 100.0 | MEG_3759 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MATE_efflux_pumps:MDTK | NA |
| contig00207 | 7 | 1755 | MSBA | 0/0 | 100.0 | 100.0 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
| contig00683 | 159 | 1127 | PMRF | 0/0 | 100.0 | 100.0 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00834 | 192 | 1007 | SULII | 0/0 | 100.0 | 100.0 | MEG_6617 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00007 | 1975 | 2811 | aph(6)-Id_1 | 0/0 | 100 | 100.0 | M28829 | aph(6)-Id | Streptomycin |
| contig00007 | 3161 | 3643 | dfrA14_5 | 0/0 | 100 | 99.8 | DQ388123 | dfrA14 | Trimethoprim |
| contig00007 | 4243 | 5058 | sul2_2 | 0/0 | 100 | 100.0 | AY034138 | sul2 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00007 | 1975 | 2811 | APH(6)-Id | 0/0 | 100.0 | 99.9 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig00559 | 529 | 1161 | CRP | 0/0 | 100.0 | 99.8 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00007 | 3161 | 3643 | dfrA14 | 0/0 | 100.0 | 100.0 | EU780012:2162-2645 | dfrA14 is an integron-encoded dihydrofolate reductase found in Escherichia coli | diaminopyrimidine |
| contig00454 | 523 | 1578 | emrK | 0/0 | 100.0 | 100.0 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00711 | 197 | 1355 | Escherichia_coli_acrA | 0/0 | 97.1 | 100.0 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig01008 | 192 | 1016 | gadX | 0/0 | 100.0 | 100.0 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00232 | 495 | 908 | H-NS | 0/0 | 100.0 | 99.3 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00031 | 1857 | 3014 | mdtE | 0/0 | 100.0 | 100.0 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00004 | 3545 | 5293 | msbA | 0/0 | 100.0 | 98.9 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| contig00007 | 4243 | 5058 | sul2 | 0/0 | 100.0 | 100.0 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig00002 | 4507 | 5994 | tolC | 0/0 | 100.0 | 100.0 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00007 | 1975 | 2811 | (AGly)strB | 0/0 | 100 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00007 | 4243 | 5058 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00007 | 3161 | 3634 | (Tmt)dfrA14 | 0/0 | 100 | 99.8 | GU726917:72-545 | (Tmt)dfrA14 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00007 | 1975 | 2811 | (AGly)strB | 0/0 | 100 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00007 | 4243 | 5058 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00007 | 3161 | 3634 | (Tmt)dfrA14 | 0/0 | 100 | 99.8 | GU726917:72-545 | (Tmt)dfrA14 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00711 | 197 | 1355 | ACRA | 0/0 | 97.1 | 100.0 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00007 | 1975 | 2811 | APH6 | 0/0 | 100.0 | 100.0 | MEG_1086 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig00559 | 529 | 1161 | CRP | 0/0 | 100.0 | 99.8 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00007 | 3161 | 3634 | DFRA | 0/0 | 100.0 | 100.0 | MEG_2517 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00454 | 523 | 1652 | EMRK | 0/0 | 97.1 | 100.0 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig01008 | 192 | 1016 | GADX | 0/0 | 100.0 | 100.0 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00232 | 495 | 908 | HNS | 0/0 | 100.0 | 99.3 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00031 | 1857 | 3014 | MDTE | 0/0 | 100.0 | 100.0 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig02252 | 317 | 624 | MDTI | 0/0 | 93.3 | 100.0 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig02252 | 1 | 330 | MDTJ | 0/0 | 90.2 | 99.7 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00004 | 3545 | 5293 | MSBA | 0/0 | 100.0 | 98.9 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
| contig00007 | 4243 | 5058 | SULII | 0/0 | 100.0 | 100.0 | MEG_6617 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00268 | 1697 | 2485 | aadA5_1 | 0/0 | 100 | 100.0 | AF137361 | aadA5 | Streptomycin |
| contig00354 | 843 | 1646 | aph(3’’)-Ib_5 | 0/0 | 100 | 100.0 | AF321551 | aph(3’’)-Ib | Streptomycin |
| contig00354 | 7 | 843 | aph(6)-Id_1 | 0/0 | 100 | 100.0 | M28829 | aph(6)-Id | Streptomycin |
| contig00971 | 109 | 969 | blaTEM-1B_1 | 0/0 | 100 | 100.0 | AY458016 | blaTEM-1B | Amoxicillin, Ampicillin, Cephalothin, Piperacillin, Ticarcillin |
| contig00268 | 2616 | 3089 | dfrA17_1 | 0/0 | 100 | 100.0 | FJ460238 | dfrA17 | Trimethoprim |
| contig00356 | 2699 | 3931 | mdf(A)_1 | 0/0 | 100 | 97.8 | Y08743 | mdf(A) | |
| contig00268 | 311 | 1177 | sul1_5 | 0/0 | 100 | 99.9 | EU780013 | sul1 | Sulfamethoxazole |
| contig00354 | 1707 | 2522 | sul2_3 | 0/0 | 100 | 100.0 | HQ840942 | sul2 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00268 | 1697 | 2485 | aadA5 | 0/0 | 100.0 | 100.0 | AF137361:63-852 | aadA5 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids transposons and integrons in E. coli K. pneumoniae Kluyvera georgiana P. aeruginosa and E. cloacae | aminoglycoside |
| contig00994 | 197 | 1354 | acrE | 0/0 | 100.0 | 98.8 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig01328 | 136 | 758 | acrS | 0/0 | 94.0 | 98.6 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00354 | 843 | 1646 | APH(3’’)-Ib | 0/0 | 100.0 | 99.8 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig00354 | 7 | 843 | APH(6)-Id | 0/0 | 100.0 | 99.9 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig00050 | 8075 | 8894 | bacA | 0/0 | 99.8 | 98.3 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00024 | 2920 | 3641 | baeR | 0/0 | 99.9 | 97.1 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00024 | 1520 | 2923 | baeS | 0/0 | 100.0 | 90.6 | AP009048:2165012-2166416 | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance. | aminocoumarin, aminoglycoside |
| contig00715 | 931 | 2304 | cpxA | 0/0 | 100.0 | 98.5 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00248 | 1517 | 2149 | CRP | 0/0 | 100.0 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00268 | 2616 | 3089 | dfrA17 | 0/0 | 100.0 | 100.0 | DQ838665:0-474 | dfrA17 is an integron-encoded dihydrofolate reductase found in Escherichia coli | diaminopyrimidine |
| contig00375 | 2087 | 3625 | emrB | 0/0 | 100.0 | 98.4 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig00052 | 1466 | 2521 | emrK | 0/0 | 100.0 | 97.7 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00765 | 435 | 965 | emrR | 0/0 | 100.0 | 98.5 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00052 | 1 | 1466 | emrY | 0/0 | 95.3 | 97.5 | D78168:1591-3130 | emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. | tetracycline |
| contig00315 | 2466 | 4109 | eptA | 0/0 | 100.0 | 91.3 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00094 | 6235 | 7428 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.1 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00011 | 1262 | 2395 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.8 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00190 | 4295 | 5452 | Escherichia_coli_ampH | 0/0 | 100.0 | 97.1 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00356 | 2699 | 3931 | Escherichia_coli_mdfA | 0/0 | 100.0 | 96.3 | JQ394987:0-1233 | Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter. | benzalkonium_chloride, rhodamine, tetracycline |
| contig00052 | 3045 | 3659 | evgA | 0/0 | 100.0 | 98.9 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00052 | 3664 | 7257 | evgS | 0/0 | 100.0 | 96.3 | U00096:2484373-2487967 | EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00596 | 1558 | 2286 | gadW | 0/0 | 100.0 | 99.9 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00596 | 365 | 1189 | gadX | 0/0 | 100.0 | 93.7 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00593 | 2426 | 2839 | H-NS | 0/0 | 100.0 | 99.3 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00022 | 1539 | 1922 | marA | 0/0 | 100.0 | 99.0 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00829 | 177 | 1424 | mdtA | 0/0 | 100.0 | 95.8 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00251 | 2925 | 4082 | mdtE | 0/0 | 100.0 | 98.3 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00251 | 1 | 2900 | mdtF | 0/0 | 93.1 | 97.0 | U00096:3660413-3663527 | MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex. | fluoroquinolone, macrolide, penam |
| contig00623 | 743 | 1969 | mdtG | 0/0 | 100.0 | 98.4 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00032 | 9316 | 10524 | mdtH | 0/0 | 100.0 | 98.3 | U00096:1125326-1124117 | Multidrug resistance protein MdtH | fluoroquinolone |
| contig00341 | 1 | 1194 | mdtM | 0/0 | 96.8 | 95.5 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00123 | 395 | 1426 | mdtN | 0/0 | 100.0 | 96.3 | AP009048.1:4307588-4306556 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride. | acridine_dye, nucleoside |
| contig00123 | 1426 | 3477 | mdtO | 0/0 | 100.0 | 97.2 | AP009048.1:4306557-4304505 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00123 | 3474 | 4940 | mdtP | 0/0 | 100.0 | 98.1 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00342 | 2197 | 3165 | pmrF | 0/0 | 100.0 | 97.5 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00268 | 311 | 1150 | sul1 | 0/0 | 100.0 | 100.0 | JF969163:1053-1893 | Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons. | sulfonamide |
| contig00354 | 1707 | 2522 | sul2 | 0/0 | 100.0 | 99.6 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig00971 | 109 | 969 | TEM-1 | 0/0 | 100.0 | 99.9 | AL513383:161910-162771 | TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. | cephalosporin, monobactam, penam, penem |
| contig00069 | 6913 | 8400 | tolC | 0/0 | 100.0 | 98.2 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| contig01114 | 62 | 1183 | ugd | 0/0 | 96.1 | 99.9 | U00096:2099613-2098446 | PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin | peptide |
| contig00116 | 6212 | 7855 | yojI | 0/0 | 100.0 | 97.3 | U00096.3:2308615-2306971 | YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00268 | 1697 | 2485 | (AGly)aadA5 | 0/0 | 100 | 100.0 | AF137361:64-852 | (AGly)aadA5 | NA |
| contig00354 | 843 | 1646 | (AGly)strA | 0/0 | 100 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00354 | 7 | 843 | (AGly)strB | 0/0 | 100 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00011 | 1262 | 2395 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.8 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00190 | 4295 | 5452 | (Bla)ampH_Ecoli | 0/0 | 100 | 97.1 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00971 | 109 | 969 | (Bla)blaTEM-105 | 0/0 | 100 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00150 | 4681 | 6582 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 98.7 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00268 | 311 | 1150 | (Sul)sul1 | 0/0 | 100 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig00354 | 1707 | 2522 | (Sul)sul2 | 0/0 | 100 | 99.6 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00268 | 2616 | 3089 | (Tmt)dfrA17 | 0/0 | 100 | 100.0 | AB126604:98-571 | (Tmt)dfrA17 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00268 | 1697 | 2485 | (AGly)aadA5 | 0/0 | 100 | 100.0 | AF137361:64-852 | (AGly)aadA5 | NA |
| contig00354 | 843 | 1646 | (AGly)strA | 0/0 | 100 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00354 | 7 | 843 | (AGly)strB | 0/0 | 100 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00011 | 1262 | 2395 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.8 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00190 | 4295 | 5452 | (Bla)ampH_Ecoli | 0/0 | 100 | 97.1 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00971 | 109 | 969 | (Bla)blaTEM-105 | 0/0 | 100 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00150 | 4681 | 6582 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 98.7 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00268 | 311 | 1150 | (Sul)sul1 | 0/0 | 100 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig00354 | 1707 | 2522 | (Sul)sul2 | 0/0 | 100 | 99.6 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00268 | 2616 | 3089 | (Tmt)dfrA17 | 0/0 | 100 | 100.0 | AB126604:98-571 | (Tmt)dfrA17 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00094 | 6235 | 7428 | ACRA | 0/0 | 100.0 | 99.1 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00994 | 197 | 1354 | ACRE | 0/0 | 100.0 | 98.8 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig01328 | 136 | 758 | ACRS | 0/0 | 94.0 | 98.6 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00190 | 4295 | 5452 | AMPH | 0/0 | 100.0 | 97.1 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00268 | 1697 | 2485 | ANT3-DPRIME | 0/0 | 100.0 | 100.0 | MEG_928 | Drugs:Aminoglycosides:Aminoglycoside_O-nucleotidyltransferases:ANT3-DPRIME | NA |
| contig00354 | 843 | 1670 | APH3-DPRIME | 0/0 | 100.0 | 100.0 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00354 | 7 | 843 | APH6 | 0/0 | 100.0 | 100.0 | MEG_1086 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig00402 | 1830 | 3682 | ASMA | 0/0 | 100.0 | 97.8 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00050 | 8075 | 8894 | BACA | 0/0 | 99.8 | 98.5 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00024 | 2920 | 3641 | BAER | 0/0 | 99.9 | 97.1 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00024 | 1520 | 2923 | BAES | 0/0 | 100.0 | 90.6 | MEG_1193 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAES | NA |
| contig00688 | 1 | 1184 | BCR | 0/0 | 99.4 | 96.6 | MEG_1210 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig00011 | 1262 | 2395 | BLAEC | 0/0 | 100.0 | 99.5 | MEG_1275 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00715 | 236 | 934 | CPXAR | 0/0 | 100.0 | 97.8 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00715 | 931 | 2304 | CPXAR | 0/0 | 100.0 | 98.9 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00248 | 1517 | 2149 | CRP | 0/0 | 100.0 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00268 | 2616 | 3089 | DFRA | 0/0 | 100.0 | 100.0 | MEG_2547 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00375 | 2087 | 3625 | EMRB | 0/0 | 100.0 | 98.4 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig00482 | 2419 | 3495 | EMRD | 0/0 | 90.4 | 97.4 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00052 | 1466 | 2629 | EMRK | 0/0 | 100.0 | 97.4 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00765 | 435 | 965 | EMRR | 0/0 | 100.0 | 98.5 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00052 | 1 | 1466 | EMRY | 0/0 | 95.3 | 97.6 | MEG_2736 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRY | NA |
| contig00315 | 2466 | 4109 | EPTA | 0/0 | 100.0 | 91.3 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00052 | 3664 | 7257 | EVGS | 0/0 | 100.0 | 97.4 | MEG_2869 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EVGS | NA |
| contig00596 | 1558 | 2286 | GADW | 0/0 | 100.0 | 99.9 | MEG_3082 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00596 | 365 | 1189 | GADX | 0/0 | 100.0 | 93.7 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00593 | 2426 | 2839 | HNS | 0/0 | 100.0 | 99.3 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00022 | 1539 | 1928 | MARA | 0/0 | 100.0 | 99.0 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00022 | 1943 | 2377 | MARR | 0/0 | 100.0 | 97.9 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00356 | 2699 | 3931 | MDFA | 0/0 | 100.0 | 97.9 | MEG_3737 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDFA | NA |
| contig00829 | 177 | 1424 | MDTA | 0/0 | 100.0 | 95.8 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00251 | 2925 | 4082 | MDTE | 0/0 | 100.0 | 98.3 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00251 | 1 | 2900 | MDTF | 0/0 | 93.1 | 97.0 | MEG_3752 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTF | NA |
| contig00623 | 743 | 1969 | MDTG | 0/0 | 100.0 | 98.5 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00032 | 9316 | 10524 | MDTH | 0/0 | 100.0 | 98.3 | MEG_3755 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTH | NA |
| contig00771 | 683 | 1012 | MDTI | 0/0 | 100.0 | 98.8 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00771 | 331 | 696 | MDTJ | 0/0 | 100.0 | 98.4 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00330 | 1615 | 2987 | MDTK | 0/0 | 99.9 | 97.7 | MEG_3759 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MATE_efflux_pumps:MDTK | NA |
| contig00341 | 1 | 1194 | MDTM | 0/0 | 96.8 | 95.5 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00123 | 395 | 1426 | MDTN | 0/0 | 100.0 | 96.3 | MEG_3763 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTN | NA |
| contig00123 | 1426 | 3477 | MDTO | 0/0 | 100.0 | 97.2 | MEG_3764 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTO | NA |
| contig00123 | 3474 | 4940 | MDTP | 0/0 | 100.0 | 98.1 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00150 | 4681 | 6582 | PBP2 | 0/0 | 100.0 | 98.7 | MEG_5400 | Drugs:betalactams:Penicillin_binding_protein:PBP2 | NA |
| contig00342 | 2197 | 3165 | PMRF | 0/0 | 100.0 | 97.5 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00101 | 1538 | 2407 | ROBA | 0/0 | 100.0 | 99.7 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00412 | 1049 | 1371 | SOXS | 0/0 | 99.7 | 98.1 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00268 | 184 | 1151 | SULI | 0/0 | 100.0 | 100.0 | MEG_6615 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULI | NA |
| contig00354 | 1707 | 2522 | SULII | 0/0 | 100.0 | 100.0 | MEG_6618 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| contig00971 | 91 | 1336 | TEM | 0/0 | 98.3 | 99.4 | MEG_6875 | Drugs:betalactams:Class_A_betalactamases:TEM | NA |
| contig01114 | 62 | 1183 | UGD | 0/0 | 96.1 | 99.9 | MEG_7328 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:UGD | NA |
| contig00116 | 6212 | 7855 | YOGI | 0/0 | 100.0 | 97.3 | MEG_7842 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_ABC_efflux_pumps:YOGI | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00014 | 2919 | 3755 | aph(6)-Id_1 | 0/0 | 100 | 99.9 | M28829 | aph(6)-Id | Streptomycin |
| contig00800 | 344 | 1204 | blaTEM-1B_1 | 0/0 | 100 | 100.0 | AY458016 | blaTEM-1B | Amoxicillin, Ampicillin, Cephalothin, Piperacillin, Ticarcillin |
| contig00931 | 42 | 551 | dfrA8_1 | 0/0 | 100 | 100.0 | U10186 | dfrA8 | Trimethoprim |
| contig00293 | 360 | 1175 | sul2_2 | 0/0 | 100 | 100.0 | AY034138 | sul2 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00014 | 2919 | 3755 | APH(6)-Id | 0/0 | 100.0 | 99.8 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig00233 | 15 | 836 | bacA | 0/0 | 100.0 | 100.0 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00058 | 620 | 1252 | CRP | 0/0 | 100.0 | 99.8 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00931 | 42 | 551 | dfrA8 | 0/0 | 100.0 | 100.0 | KJ174469:710-1220 | dfrA8 is a transposon-encoded dihydrofolate reductase found in Salmonella enterica | diaminopyrimidine |
| contig00166 | 544 | 2082 | emrB | 0/0 | 100.0 | 100.0 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig01094 | 376 | 906 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00108 | 105 | 1748 | eptA | 0/0 | 100.0 | 99.9 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00104 | 986 | 1600 | evgA | 0/0 | 100.0 | 100.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig01233 | 230 | 972 | gadX | 0/0 | 90.1 | 100.0 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00135 | 1623 | 2006 | marA | 0/0 | 100.0 | 100.0 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00010 | 2447 | 3604 | mdtE | 0/0 | 100.0 | 100.0 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00287 | 1329 | 1805 | mphB | 0/0 | 100.0 | 98.3 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00301 | 323 | 1291 | pmrF | 0/0 | 100.0 | 100.0 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00293 | 360 | 1175 | sul2 | 0/0 | 100.0 | 100.0 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig00800 | 344 | 1204 | TEM-1 | 0/0 | 100.0 | 99.9 | AL513383:161910-162771 | TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. | cephalosporin, monobactam, penam, penem |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00014 | 2919 | 3755 | (AGly)strB | 0/0 | 100 | 99.9 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00800 | 344 | 1204 | (Bla)blaTEM-105 | 0/0 | 100 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00293 | 360 | 1175 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00931 | 42 | 551 | (Tmt)dfrA8 | 0/0 | 100 | 100.0 | U10186:711-1220 | (Tmt)dfrA8 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00014 | 2919 | 3755 | (AGly)strB | 0/0 | 100 | 99.9 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00800 | 344 | 1204 | (Bla)blaTEM-105 | 0/0 | 100 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00293 | 360 | 1175 | (Sul)sul2 | 0/0 | 100 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00931 | 42 | 551 | (Tmt)dfrA8 | 0/0 | 100 | 100.0 | U10186:711-1220 | (Tmt)dfrA8 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00014 | 2919 | 3755 | APH6 | 0/0 | 100.0 | 100.0 | MEG_1084 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig00233 | 15 | 836 | BACA | 0/0 | 100.0 | 100.0 | MEG_1190 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00058 | 620 | 1252 | CRP | 0/0 | 100.0 | 99.8 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00931 | 42 | 551 | DFRA | 0/0 | 100.0 | 100.0 | MEG_2553 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00166 | 544 | 2082 | EMRB | 0/0 | 100.0 | 100.0 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig01094 | 376 | 906 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00108 | 105 | 1748 | EPTA | 0/0 | 100.0 | 99.9 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig01233 | 230 | 972 | GADX | 0/0 | 90.1 | 100.0 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00135 | 1617 | 2006 | MARA | 0/0 | 100.0 | 100.0 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00135 | 1169 | 1603 | MARR | 0/0 | 100.0 | 100.0 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00010 | 2447 | 3604 | MDTE | 0/0 | 100.0 | 100.0 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00287 | 1329 | 1805 | MPHB | 0/0 | 100.0 | 98.3 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00301 | 323 | 1291 | PMRF | 0/0 | 100.0 | 100.0 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00293 | 360 | 1175 | SULII | 0/0 | 100.0 | 100.0 | MEG_6617 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00170 | 804 | 1606 | aph(3’’)-Ib_2 | 0/0 | 99.9 | 100.0 | AF024602 | aph(3’’)-Ib | Streptomycin |
| contig00170 | 1 | 804 | aph(6)-Id_1 | 0/0 | 96.1 | 100.0 | M28829 | aph(6)-Id | Streptomycin |
| contig01367 | 1 | 819 | blaTEM-1C_1 | 0/0 | 95.1 | 100.0 | FJ560503 | blaTEM-1C | Amoxicillin, Ampicillin, Cephalothin, Piperacillin, Ticarcillin |
| contig00361 | 805 | 1278 | dfrA1_10 | 0/0 | 100.0 | 99.8 | AF203818 | dfrA1 | Trimethoprim |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00170 | 804 | 1607 | APH(3’’)-Ib | 0/0 | 100.0 | 99.9 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig00170 | 1 | 804 | APH(6)-Id | 0/0 | 96.1 | 99.9 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig00361 | 805 | 1278 | dfrA1 | 0/0 | 100.0 | 100.0 | KJ541681.1:19526-20000 | dfrA1 is an integron-encoded dihydrofolate reductase | diaminopyrimidine |
| contig00061 | 1010 | 2526 | emrB | 0/0 | 98.6 | 98.0 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig00537 | 291 | 1284 | emrK | 0/0 | 94.1 | 97.8 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00006 | 1 | 1613 | eptA | 0/0 | 98.1 | 98.1 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig02880 | 68 | 467 | H-NS | 0/0 | 96.6 | 99.5 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00410 | 357 | 831 | mphB | 0/0 | 99.6 | 96.6 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig01367 | 1 | 819 | TEM-1 | 0/0 | 95.1 | 100.0 | AL513383:161910-162771 | TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. | cephalosporin, monobactam, penam, penem |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00170 | 804 | 1607 | (AGly)strA | 0/0 | 100.0 | 100.0 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00170 | 1 | 804 | (AGly)strB | 0/0 | 96.1 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig01367 | 1 | 819 | (Bla)blaTEM-135 | 0/0 | 95.1 | 99.9 | JQ060998:1-861 | (Bla)blaTEM-135 | NA |
| contig00361 | 805 | 1278 | (Tmt)dfrA1 | 0/0 | 100.0 | 99.8 | JQ794607:474 | (Tmt)dfrA1 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00170 | 804 | 1607 | (AGly)strA | 0/0 | 100.0 | 100.0 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00170 | 1 | 804 | (AGly)strB | 0/0 | 96.1 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig01367 | 1 | 819 | (Bla)blaTEM-135 | 0/0 | 95.1 | 99.9 | JQ060998:1-861 | (Bla)blaTEM-135 | NA |
| contig00361 | 805 | 1278 | (Tmt)dfrA1 | 0/0 | 100.0 | 99.8 | JQ794607:474 | (Tmt)dfrA1 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00170 | 804 | 1631 | APH3-DPRIME | 0/0 | 100.0 | 99.9 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00170 | 1 | 804 | APH6 | 0/0 | 96.1 | 100.0 | MEG_1086 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig01091 | 176 | 874 | CPXAR | 0/0 | 100.0 | 99.4 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00361 | 805 | 1278 | DFRA | 0/0 | 100.0 | 99.8 | MEG_2528 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00061 | 1010 | 2526 | EMRB | 0/0 | 98.6 | 98.0 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig00006 | 1 | 1613 | EPTA | 0/0 | 98.1 | 98.1 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig02880 | 68 | 467 | HNS | 0/0 | 96.6 | 99.5 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig01411 | 60 | 494 | MARR | 0/0 | 100.0 | 97.9 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00410 | 357 | 831 | MPHB | 0/0 | 99.6 | 96.6 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00416 | 730 | 1052 | SOXS | 0/0 | 99.7 | 97.5 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig01367 | 1 | 819 | TEM | 0/0 | 95.1 | 100.0 | MEG_6740 | Drugs:betalactams:Class_A_betalactamases:TEM | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00913 | 364 | 1166 | aph(3’’)-Ib_2 | 0/0 | 99.9 | 100 | AF024602 | aph(3’’)-Ib | Streptomycin |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00136 | 1 | 2909 | acrB | 0/0 | 92.3 | 99.0 | U00096.3:484403-481253 | Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00913 | 364 | 1167 | APH(3’’)-Ib | 0/0 | 100.0 | 99.9 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig01222 | 252 | 884 | CRP | 0/0 | 100.0 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00870 | 292 | 1347 | emrK | 0/0 | 100.0 | 98.3 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig01441 | 189 | 719 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00042 | 2402 | 3939 | eptA | 0/0 | 93.5 | 99.3 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00047 | 2491 | 3684 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.8 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00002 | 2332 | 3489 | Escherichia_coli_ampH | 0/0 | 100.0 | 98.7 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00276 | 420 | 1034 | evgA | 0/0 | 100.0 | 99.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig01599 | 17 | 841 | gadX | 0/0 | 100.0 | 97.9 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig02908 | 16 | 429 | H-NS | 0/0 | 100.0 | 99.0 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00073 | 561 | 1718 | mdtE | 0/0 | 100.0 | 99.6 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00396 | 89 | 2003 | mdtO | 0/0 | 93.3 | 98.1 | AP009048.1:4306557-4304505 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00286 | 1118 | 1594 | mphB | 0/0 | 100.0 | 98.1 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00913 | 364 | 1167 | (AGly)strA | 0/0 | 100 | 100.0 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00002 | 2332 | 3489 | (Bla)ampH_Ecoli | 0/0 | 100 | 98.7 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00913 | 364 | 1167 | (AGly)strA | 0/0 | 100 | 100.0 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00002 | 2332 | 3489 | (Bla)ampH_Ecoli | 0/0 | 100 | 98.7 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00047 | 2491 | 3684 | ACRA | 0/0 | 100.0 | 99.8 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00136 | 1 | 2909 | ACRB | 0/0 | 92.3 | 99.0 | MEG_401 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRB | NA |
| contig00002 | 2332 | 3489 | AMPH | 0/0 | 100.0 | 98.7 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00913 | 364 | 1191 | APH3-DPRIME | 0/0 | 100.0 | 99.9 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00520 | 873 | 1571 | CPXAR | 0/0 | 100.0 | 99.4 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig01222 | 252 | 884 | CRP | 0/0 | 100.0 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00993 | 1 | 1097 | EMRD | 0/0 | 92.1 | 99.9 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00870 | 292 | 1377 | EMRK | 0/0 | 93.3 | 98.3 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig01441 | 189 | 719 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00042 | 2402 | 3939 | EPTA | 0/0 | 93.5 | 99.3 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig01599 | 17 | 841 | GADX | 0/0 | 100.0 | 97.9 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig02908 | 16 | 429 | HNS | 0/0 | 100.0 | 99.0 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00073 | 561 | 1718 | MDTE | 0/0 | 100.0 | 99.6 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00928 | 435 | 764 | MDTI | 0/0 | 100.0 | 99.1 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00928 | 751 | 1116 | MDTJ | 0/0 | 100.0 | 99.7 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00396 | 89 | 2003 | MDTO | 0/0 | 93.3 | 98.1 | MEG_3764 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTO | NA |
| contig00286 | 1118 | 1594 | MPHB | 0/0 | 100.0 | 98.1 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00262 | 422 | 1291 | ROBA | 0/0 | 100.0 | 99.4 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00141 | 1735 | 2058 | SOXS | 0/0 | 100.0 | 100.0 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
## [1] "No antibiotic resitance genes from Resfinder database were found"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00964 | 197 | 1354 | acrE | 0/0 | 100.0 | 99.0 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00396 | 2471 | 3133 | acrS | 0/0 | 100.0 | 98.9 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00079 | 2838 | 3560 | baeR | 0/0 | 100.0 | 100.0 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00079 | 1438 | 2841 | baeS | 0/0 | 100.0 | 100.0 | AP009048:2165012-2166416 | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance. | aminocoumarin, aminoglycoside |
| contig00625 | 987 | 2360 | cpxA | 0/0 | 100.0 | 99.0 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00722 | 1032 | 1664 | CRP | 0/0 | 100.0 | 99.8 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00076 | 3936 | 5108 | emrA | 0/0 | 100.0 | 100.0 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig00076 | 2381 | 3919 | emrB | 0/0 | 100.0 | 100.0 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig00541 | 1231 | 2286 | emrK | 0/0 | 100.0 | 99.9 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00076 | 5235 | 5765 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00109 | 1794 | 3437 | eptA | 0/0 | 100.0 | 100.0 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00611 | 335 | 1528 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.9 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00003 | 7904 | 9037 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.3 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00036 | 2502 | 3659 | Escherichia_coli_ampH | 0/0 | 100.0 | 98.8 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00186 | 21 | 635 | evgA | 0/0 | 100.0 | 100.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00186 | 640 | 4233 | evgS | 0/0 | 100.0 | 99.7 | U00096:2484373-2487967 | EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00243 | 1181 | 1909 | gadW | 0/0 | 100.0 | 94.7 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00243 | 1 | 813 | gadX | 0/0 | 98.5 | 100.0 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00241 | 1494 | 1907 | H-NS | 0/0 | 100.0 | 99.5 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00496 | 1997 | 2380 | marA | 0/0 | 100.0 | 99.7 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00490 | 1305 | 2462 | mdtE | 0/0 | 100.0 | 100.0 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00218 | 1521 | 2729 | mdtH | 0/0 | 100.0 | 100.0 | U00096:1125326-1124117 | Multidrug resistance protein MdtH | fluoroquinolone |
| contig00709 | 414 | 1646 | mdtM | 0/0 | 100.0 | 96.3 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00411 | 395 | 1426 | mdtN | 0/0 | 100.0 | 100.0 | AP009048.1:4307588-4306556 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride. | acridine_dye, nucleoside |
| contig00437 | 90 | 1556 | mdtP | 0/0 | 100.0 | 100.0 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00484 | 485 | 2233 | msbA | 0/0 | 100.0 | 100.0 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| contig00230 | 1130 | 2296 | ugd | 0/0 | 100.0 | 96.7 | U00096:2099613-2098446 | PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin | peptide |
| contig00477 | 1176 | 2819 | yojI | 0/0 | 100.0 | 100.0 | U00096.3:2308615-2306971 | YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00003 | 7904 | 9037 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.3 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00036 | 2502 | 3659 | (Bla)ampH_Ecoli | 0/0 | 100 | 98.8 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00358 | 1082 | 2983 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 100.0 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00003 | 7904 | 9037 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.3 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00036 | 2502 | 3659 | (Bla)ampH_Ecoli | 0/0 | 100 | 98.8 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00358 | 1082 | 2983 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 100.0 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00611 | 335 | 1528 | ACRA | 0/0 | 100.0 | 99.9 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00964 | 197 | 1354 | ACRE | 0/0 | 100.0 | 99.0 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig00396 | 2471 | 3133 | ACRS | 0/0 | 100.0 | 98.9 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00036 | 2502 | 3659 | AMPH | 0/0 | 100.0 | 98.8 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00079 | 2838 | 3560 | BAER | 0/0 | 100.0 | 100.0 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00079 | 1438 | 2841 | BAES | 0/0 | 100.0 | 100.0 | MEG_1193 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAES | NA |
| contig00734 | 817 | 2007 | BCR | 0/0 | 100.0 | 100.0 | MEG_1210 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig00003 | 7904 | 9037 | BLAEC | 0/0 | 100.0 | 98.6 | MEG_1282 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00625 | 292 | 990 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2122 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00625 | 987 | 2360 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00722 | 1032 | 1664 | CRP | 0/0 | 100.0 | 99.8 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00076 | 3936 | 5108 | EMRA | 0/0 | 100.0 | 100.0 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig00076 | 2381 | 3919 | EMRB | 0/0 | 100.0 | 100.0 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig00465 | 1534 | 2724 | EMRD | 0/0 | 100.0 | 100.0 | MEG_2729 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRD | NA |
| contig00541 | 1231 | 2394 | EMRK | 0/0 | 100.0 | 99.9 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00076 | 5235 | 5765 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00109 | 1794 | 3437 | EPTA | 0/0 | 100.0 | 100.0 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00186 | 640 | 4233 | EVGS | 0/0 | 100.0 | 99.7 | MEG_2870 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EVGS | NA |
| contig00243 | 1181 | 1909 | GADW | 0/0 | 100.0 | 100.0 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00243 | 1 | 813 | GADX | 0/0 | 98.5 | 100.0 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00241 | 1494 | 1907 | HNS | 0/0 | 100.0 | 99.5 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00496 | 1991 | 2380 | MARA | 0/0 | 100.0 | 99.7 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00496 | 1543 | 1977 | MARR | 0/0 | 100.0 | 97.5 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00490 | 1305 | 2462 | MDTE | 0/0 | 100.0 | 100.0 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00218 | 1521 | 2729 | MDTH | 0/0 | 100.0 | 100.0 | MEG_3755 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTH | NA |
| contig00687 | 1415 | 1744 | MDTI | 0/0 | 100.0 | 100.0 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00687 | 1063 | 1428 | MDTJ | 0/0 | 100.0 | 99.5 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00568 | 1275 | 2581 | MDTK | 0/0 | 95.1 | 100.0 | MEG_3759 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MATE_efflux_pumps:MDTK | NA |
| contig00709 | 414 | 1646 | MDTM | 0/0 | 100.0 | 96.3 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00411 | 395 | 1426 | MDTN | 0/0 | 100.0 | 100.0 | MEG_3763 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTN | NA |
| contig00437 | 90 | 1556 | MDTP | 0/0 | 100.0 | 100.0 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00484 | 485 | 2233 | MSBA | 0/0 | 100.0 | 100.0 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
| contig00358 | 1082 | 2983 | PBP2 | 0/0 | 100.0 | 100.0 | MEG_5400 | Drugs:betalactams:Penicillin_binding_protein:PBP2 | NA |
| contig00161 | 3743 | 4612 | ROBA | 0/0 | 100.0 | 99.0 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00394 | 2898 | 3220 | SOXS | 0/0 | 99.7 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00230 | 1130 | 2296 | UGD | 0/0 | 100.0 | 96.7 | MEG_7328 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:UGD | NA |
| contig00477 | 1176 | 2819 | YOGI | 0/0 | 100.0 | 100.0 | MEG_7842 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_ABC_efflux_pumps:YOGI | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00005 | 5855 | 6328 | dfrA1_10 | 0/0 | 100 | 99.8 | AF203818 | dfrA1 | Trimethoprim |
| contig00005 | 3627 | 4493 | sul1_5 | 0/0 | 100 | 99.9 | EU780013 | sul1 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01894 | 36 | 814 | bacA | 0/0 | 94.8 | 98.6 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00722 | 578 | 1210 | CRP | 0/0 | 100.0 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00005 | 5855 | 6328 | dfrA1 | 0/0 | 100.0 | 100.0 | KJ541681.1:19526-20000 | dfrA1 is an integron-encoded dihydrofolate reductase | diaminopyrimidine |
| contig00032 | 1997 | 3052 | emrK | 0/0 | 100.0 | 99.7 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig01432 | 50 | 580 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00032 | 459 | 1997 | emrY | 0/0 | 100.0 | 98.8 | D78168:1591-3130 | emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. | tetracycline |
| contig00323 | 1140 | 2333 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.8 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00010 | 4248 | 5381 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.7 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00024 | 430 | 1587 | Escherichia_coli_ampH | 0/0 | 100.0 | 98.9 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00032 | 3576 | 4190 | evgA | 0/0 | 100.0 | 99.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00271 | 1282 | 2010 | gadW | 0/0 | 100.0 | 94.4 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00271 | 90 | 914 | gadX | 0/0 | 100.0 | 97.9 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig01122 | 299 | 682 | marA | 0/0 | 100.0 | 99.2 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00075 | 1226 | 2383 | mdtE | 0/0 | 100.0 | 99.7 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00563 | 191 | 1423 | mdtM | 0/0 | 100.0 | 96.0 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00212 | 1333 | 1809 | mphB | 0/0 | 100.0 | 97.9 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00154 | 47 | 1795 | msbA | 0/0 | 100.0 | 99.3 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| contig00005 | 3627 | 4466 | sul1 | 0/0 | 100.0 | 100.0 | JF969163:1053-1893 | Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons. | sulfonamide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00005 | 4971 | 5772 | (AGly)aadA1-pm | 0/0 | 96.5 | 99.9 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00010 | 4248 | 5381 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 97.7 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00024 | 430 | 1587 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 98.9 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00199 | 931 | 2832 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100.0 | 99.4 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00005 | 3627 | 4466 | (Sul)sul1 | 0/0 | 100.0 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig01684 | 45 | 695 | (Tet)tetR | 0/0 | 100.0 | 100.0 | HF545434:53576-54226 | (Tet)tetR | NA |
| contig00005 | 5855 | 6328 | (Tmt)dfrA1 | 0/0 | 100.0 | 99.8 | JQ794607:474 | (Tmt)dfrA1 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00005 | 4971 | 5772 | (AGly)aadA1-pm | 0/0 | 96.5 | 99.9 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00010 | 4248 | 5381 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 97.7 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00024 | 430 | 1587 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 98.9 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00199 | 931 | 2832 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100.0 | 99.4 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00005 | 3627 | 4466 | (Sul)sul1 | 0/0 | 100.0 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig01684 | 45 | 695 | (Tet)tetR | 0/0 | 100.0 | 100.0 | HF545434:53576-54226 | (Tet)tetR | NA |
| contig00005 | 5855 | 6328 | (Tmt)dfrA1 | 0/0 | 100.0 | 99.8 | JQ794607:474 | (Tmt)dfrA1 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00323 | 1140 | 2333 | ACRA | 0/0 | 100.0 | 99.8 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00024 | 430 | 1587 | AMPH | 0/0 | 100.0 | 98.9 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00005 | 4971 | 5772 | ANT3-DPRIME | 0/0 | 96.5 | 99.9 | MEG_915 | Drugs:Aminoglycosides:Aminoglycoside_O-nucleotidyltransferases:ANT3-DPRIME | NA |
| contig01894 | 36 | 814 | BACA | 0/0 | 94.8 | 98.8 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00010 | 4248 | 5381 | BLAEC | 0/0 | 100.0 | 99.2 | MEG_1279 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00564 | 869 | 1567 | CPXAR | 0/0 | 100.0 | 100.0 | MEG_2122 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00722 | 578 | 1210 | CRP | 0/0 | 100.0 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00005 | 5855 | 6328 | DFRA | 0/0 | 100.0 | 99.8 | MEG_2528 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00032 | 1997 | 3160 | EMRK | 0/0 | 100.0 | 99.7 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig01432 | 50 | 580 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00032 | 459 | 1997 | EMRY | 0/0 | 100.0 | 98.9 | MEG_2736 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRY | NA |
| contig00271 | 1282 | 2010 | GADW | 0/0 | 100.0 | 98.6 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00271 | 90 | 914 | GADX | 0/0 | 100.0 | 97.9 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig01122 | 293 | 682 | MARA | 0/0 | 100.0 | 99.2 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00075 | 1226 | 2383 | MDTE | 0/0 | 100.0 | 99.7 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00170 | 1611 | 2984 | MDTK | 0/0 | 100.0 | 99.0 | MEG_3759 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MATE_efflux_pumps:MDTK | NA |
| contig00563 | 191 | 1423 | MDTM | 0/0 | 100.0 | 96.0 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00212 | 1333 | 1809 | MPHB | 0/0 | 100.0 | 97.9 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00154 | 47 | 1795 | MSBA | 0/0 | 100.0 | 99.3 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
| contig00199 | 931 | 2832 | PBP2 | 0/0 | 100.0 | 99.4 | MEG_5400 | Drugs:betalactams:Penicillin_binding_protein:PBP2 | NA |
| contig00071 | 2328 | 3197 | ROBA | 0/0 | 100.0 | 99.2 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00168 | 761 | 1084 | SOXS | 0/0 | 100.0 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00005 | 3500 | 4467 | SULI | 0/0 | 100.0 | 100.0 | MEG_6615 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULI | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00047 | 13624 | 14856 | mdf(A)_1 | 0/0 | 100 | 99.1 | Y08743 | mdf(A) | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00011 | 17630 | 20779 | acrB | 0/0 | 100.0 | 99.1 | U00096.3:484403-481253 | Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00288 | 1 | 2814 | acrD | 0/0 | 90.4 | 98.8 | AP009048.1:2586250-2589364 | AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole and is regulated by baeRS and cpxAR. | aminoglycoside |
| contig00033 | 8238 | 9395 | acrE | 0/0 | 100.0 | 98.9 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00033 | 5122 | 8226 | acrF | 0/0 | 100.0 | 99.0 | U00096:3415032-3418137 | AcrF is a inner membrane transporter similar to AcrB. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00033 | 9794 | 10456 | acrS | 0/0 | 100.0 | 98.8 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00723 | 93 | 912 | bacA | 0/0 | 99.8 | 98.5 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00058 | 2306 | 3028 | baeR | 0/0 | 100.0 | 98.1 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00058 | 906 | 2309 | baeS | 0/0 | 100.0 | 99.9 | AP009048:2165012-2166416 | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance. | aminocoumarin, aminoglycoside |
| contig00327 | 3587 | 4960 | cpxA | 0/0 | 100.0 | 98.8 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00260 | 2156 | 2788 | CRP | 0/0 | 100.0 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00427 | 478 | 1650 | emrA | 0/0 | 100.0 | 98.2 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig00008 | 8335 | 9390 | emrK | 0/0 | 100.0 | 99.7 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00427 | 1777 | 2307 | emrR | 0/0 | 100.0 | 100.0 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00008 | 6797 | 8335 | emrY | 0/0 | 100.0 | 98.7 | D78168:1591-3130 | emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. | tetracycline |
| contig00112 | 2402 | 4045 | eptA | 0/0 | 100.0 | 99.3 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00011 | 20802 | 21995 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.6 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00040 | 3213 | 4346 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.7 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00241 | 3891 | 5195 | Escherichia_coli_ampC1_beta-lactamase | 0/0 | 100.0 | 98.2 | FN649414.1:2765050-2766355 | An ampC-like beta-lactamase identified from Escherichia coli. | cephalosporin, penam |
| contig00107 | 5238 | 6395 | Escherichia_coli_ampH | 0/0 | 100.0 | 99.3 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00047 | 13624 | 14856 | Escherichia_coli_mdfA | 0/0 | 100.0 | 97.6 | JQ394987:0-1233 | Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter. | benzalkonium_chloride, rhodamine, tetracycline |
| contig00008 | 9914 | 10528 | evgA | 0/0 | 100.0 | 99.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00008 | 10533 | 14126 | evgS | 0/0 | 100.0 | 99.4 | U00096:2484373-2487967 | EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00365 | 1568 | 2296 | gadW | 0/0 | 100.0 | 94.4 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00365 | 376 | 1200 | gadX | 0/0 | 100.0 | 97.7 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00448 | 25 | 438 | H-NS | 0/0 | 100.0 | 99.0 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00367 | 3827 | 4483 | kdpE | 0/0 | 96.9 | 97.3 | U00096.3:721733-721055 | kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding. | aminoglycoside |
| contig00082 | 1627 | 2010 | marA | 0/0 | 100.0 | 99.5 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00295 | 4093 | 5340 | mdtA | 0/0 | 100.0 | 98.1 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00295 | 971 | 4093 | mdtB | 0/0 | 100.0 | 98.4 | U00096:2155262-2158385 | MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. | aminocoumarin |
| contig00458 | 1236 | 2393 | mdtE | 0/0 | 100.0 | 99.7 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00164 | 6425 | 7651 | mdtG | 0/0 | 100.0 | 98.9 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00083 | 9270 | 10478 | mdtH | 0/0 | 100.0 | 98.5 | U00096:1125326-1124117 | Multidrug resistance protein MdtH | fluoroquinolone |
| contig00390 | 2061 | 3293 | mdtM | 0/0 | 100.0 | 95.9 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00360 | 3536 | 4567 | mdtN | 0/0 | 100.0 | 98.0 | AP009048.1:4307588-4306556 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride. | acridine_dye, nucleoside |
| contig00301 | 1 | 1984 | mdtO | 0/0 | 96.7 | 98.3 | AP009048.1:4306557-4304505 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00301 | 1981 | 3447 | mdtP | 0/0 | 100.0 | 98.3 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00037 | 4591 | 5065 | mphB | 0/0 | 99.6 | 97.5 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00034 | 4736 | 6484 | msbA | 0/0 | 100.0 | 99.3 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| contig00174 | 3501 | 4469 | pmrF | 0/0 | 100.0 | 99.9 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00122 | 3476 | 4963 | tolC | 0/0 | 100.0 | 98.4 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| contig00309 | 231 | 1397 | ugd | 0/0 | 100.0 | 95.5 | U00096:2099613-2098446 | PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin | peptide |
| contig00446 | 1273 | 2916 | yojI | 0/0 | 100.0 | 98.0 | U00096.3:2308615-2306971 | YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00241 | 3891 | 5195 | (Bla)AmpC1_Ecoli | 0/0 | 100 | 98.2 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00040 | 3213 | 4346 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.7 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00107 | 5238 | 6395 | (Bla)ampH_Ecoli | 0/0 | 100 | 99.3 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00027 | 10413 | 12314 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 98.7 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00241 | 3891 | 5195 | (Bla)AmpC1_Ecoli | 0/0 | 100 | 98.2 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00040 | 3213 | 4346 | (Bla)AmpC2_Ecoli | 0/0 | 100 | 97.7 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00107 | 5238 | 6395 | (Bla)ampH_Ecoli | 0/0 | 100 | 99.3 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00027 | 10413 | 12314 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100 | 98.7 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00011 | 20802 | 21995 | ACRA | 0/0 | 100.0 | 99.6 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00011 | 17630 | 20779 | ACRB | 0/0 | 100.0 | 99.1 | MEG_401 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRB | NA |
| contig00288 | 1 | 2814 | ACRD | 0/0 | 90.4 | 98.8 | MEG_407 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ACRD | NA |
| contig00033 | 8238 | 9395 | ACRE | 0/0 | 100.0 | 98.9 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig00033 | 5122 | 8226 | ACRF | 0/0 | 100.0 | 99.0 | MEG_409 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRF | NA |
| contig00033 | 9794 | 10456 | ACRS | 0/0 | 100.0 | 98.8 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00107 | 5238 | 6395 | AMPH | 0/0 | 100.0 | 99.3 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00158 | 5471 | 7323 | ASMA | 0/0 | 100.0 | 98.3 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00723 | 93 | 912 | BACA | 0/0 | 99.8 | 98.8 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00058 | 2306 | 3028 | BAER | 0/0 | 100.0 | 98.1 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00058 | 906 | 2309 | BAES | 0/0 | 100.0 | 99.9 | MEG_1193 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAES | NA |
| contig00435 | 487 | 1677 | BCR | 0/0 | 100.0 | 97.9 | MEG_1210 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig00040 | 3213 | 4346 | BLAEC | 0/0 | 100.0 | 99.9 | MEG_1279 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00327 | 2892 | 3590 | CPXAR | 0/0 | 100.0 | 99.4 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00327 | 3587 | 4960 | CPXAR | 0/0 | 100.0 | 99.5 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00260 | 2156 | 2788 | CRP | 0/0 | 100.0 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00427 | 478 | 1650 | EMRA | 0/0 | 100.0 | 98.2 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig00008 | 8335 | 9498 | EMRK | 0/0 | 100.0 | 99.7 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00427 | 1777 | 2307 | EMRR | 0/0 | 100.0 | 100.0 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00008 | 6797 | 8335 | EMRY | 0/0 | 100.0 | 98.8 | MEG_2736 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRY | NA |
| contig00112 | 2402 | 4045 | EPTA | 0/0 | 100.0 | 99.3 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig00008 | 10533 | 14126 | EVGS | 0/0 | 100.0 | 99.4 | MEG_2870 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EVGS | NA |
| contig00365 | 1568 | 2296 | GADW | 0/0 | 100.0 | 98.6 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00365 | 376 | 1200 | GADX | 0/0 | 100.0 | 97.7 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00448 | 25 | 438 | HNS | 0/0 | 100.0 | 99.0 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00367 | 3827 | 4483 | KDPE | 0/0 | 96.9 | 97.3 | MEG_3448 | Drugs:Aminoglycosides:Aminoglycoside_efflux_pumps:KDPE | NA |
| contig00082 | 1621 | 2010 | MARA | 0/0 | 100.0 | 99.5 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00082 | 1173 | 1607 | MARR | 0/0 | 100.0 | 97.7 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00047 | 13624 | 14856 | MDFA | 0/0 | 100.0 | 99.2 | MEG_3737 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDFA | NA |
| contig00295 | 4093 | 5340 | MDTA | 0/0 | 100.0 | 98.1 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00295 | 971 | 4093 | MDTB | 0/0 | 100.0 | 98.4 | MEG_3747 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTB | NA |
| contig00458 | 1236 | 2393 | MDTE | 0/0 | 100.0 | 99.7 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00164 | 6425 | 7651 | MDTG | 0/0 | 100.0 | 99.0 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00083 | 9270 | 10478 | MDTH | 0/0 | 100.0 | 98.5 | MEG_3755 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTH | NA |
| contig00291 | 5063 | 5392 | MDTI | 0/0 | 100.0 | 99.7 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00291 | 4711 | 5076 | MDTJ | 0/0 | 100.0 | 98.9 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00357 | 1653 | 3026 | MDTK | 0/0 | 100.0 | 99.0 | MEG_3759 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MATE_efflux_pumps:MDTK | NA |
| contig00390 | 2061 | 3293 | MDTM | 0/0 | 100.0 | 95.9 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00360 | 3536 | 4567 | MDTN | 0/0 | 100.0 | 98.0 | MEG_3763 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTN | NA |
| contig00301 | 1 | 1984 | MDTO | 0/0 | 96.7 | 98.3 | MEG_3764 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTO | NA |
| contig00301 | 1981 | 3447 | MDTP | 0/0 | 100.0 | 98.3 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig00037 | 4591 | 5065 | MPHB | 0/0 | 99.6 | 97.5 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00034 | 4736 | 6484 | MSBA | 0/0 | 100.0 | 99.3 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
| contig00027 | 10413 | 12314 | PBP2 | 0/0 | 100.0 | 98.7 | MEG_5400 | Drugs:betalactams:Penicillin_binding_protein:PBP2 | NA |
| contig00241 | 3891 | 5195 | PBP4B | 0/0 | 100.0 | 98.2 | MEG_5409 | Drugs:betalactams:Penicillin_binding_protein:PBP4B | NA |
| contig00174 | 3501 | 4469 | PMRF | 0/0 | 100.0 | 99.9 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00063 | 11897 | 12766 | ROBA | 0/0 | 100.0 | 99.1 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00046 | 8027 | 8350 | SOXS | 0/0 | 100.0 | 100.0 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00309 | 231 | 1397 | UGD | 0/0 | 100.0 | 95.5 | MEG_7328 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:UGD | NA |
| contig00446 | 1273 | 2916 | YOGI | 0/0 | 100.0 | 98.0 | MEG_7842 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_ABC_efflux_pumps:YOGI | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00021 | 2698 | 3534 | aph(6)-Id_1 | 0/0 | 100 | 100.0 | M28829 | aph(6)-Id | Streptomycin |
| contig00021 | 3884 | 4366 | dfrA14_5 | 0/0 | 100 | 99.8 | DQ388123 | dfrA14 | Trimethoprim |
| contig00021 | 4966 | 5781 | sul2_2 | 0/0 | 100 | 100.0 | AY034138 | sul2 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01133 | 197 | 1328 | acrE | 0/0 | 97.8 | 98.5 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig01150 | 622 | 1284 | acrS | 0/0 | 100.0 | 97.9 | U00096:3413465-3412802 | AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. | cephalosporin, cephamycin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00021 | 2698 | 3534 | APH(6)-Id | 0/0 | 100.0 | 99.9 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig01389 | 93 | 912 | bacA | 0/0 | 99.8 | 97.1 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00053 | 3396 | 4118 | baeR | 0/0 | 100.0 | 96.3 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00353 | 1924 | 2556 | CRP | 0/0 | 100.0 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00021 | 3884 | 4366 | dfrA14 | 0/0 | 100.0 | 100.0 | EU780012:2162-2645 | dfrA14 is an integron-encoded dihydrofolate reductase found in Escherichia coli | diaminopyrimidine |
| contig00673 | 336 | 1469 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.9 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00008 | 6303 | 7607 | Escherichia_coli_ampC1_beta-lactamase | 0/0 | 100.0 | 95.9 | FN649414.1:2765050-2766355 | An ampC-like beta-lactamase identified from Escherichia coli. | cephalosporin, penam |
| contig00987 | 403 | 1495 | Escherichia_coli_ampH | 0/0 | 94.4 | 99.3 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00647 | 16 | 348 | Escherichia_coli_emrE | 0/0 | 100.0 | 91.6 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig01283 | 298 | 912 | evgA | 0/0 | 100.0 | 99.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00638 | 1 | 713 | gadW | 0/0 | 97.8 | 96.6 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig01435 | 192 | 1016 | gadX | 0/0 | 100.0 | 93.9 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig01367 | 300 | 683 | marA | 0/0 | 100.0 | 99.7 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00614 | 154 | 1401 | mdtA | 0/0 | 100.0 | 96.9 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00112 | 571 | 1728 | mdtE | 0/0 | 100.0 | 98.5 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00358 | 720 | 1946 | mdtG | 0/0 | 100.0 | 98.0 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig01088 | 7 | 1239 | mdtM | 0/0 | 100.0 | 96.3 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00138 | 449 | 1480 | mdtN | 0/0 | 100.0 | 97.7 | AP009048.1:4307588-4306556 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride. | acridine_dye, nucleoside |
| contig00138 | 1480 | 3531 | mdtO | 0/0 | 100.0 | 97.0 | AP009048.1:4306557-4304505 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00584 | 810 | 1284 | mphB | 0/0 | 99.6 | 97.0 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00404 | 833 | 1801 | pmrF | 0/0 | 100.0 | 96.3 | U00096:2367070-2368039 | PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. | peptide |
| contig00021 | 4966 | 5781 | sul2 | 0/0 | 100.0 | 100.0 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig00018 | 2861 | 4348 | tolC | 0/0 | 100.0 | 98.3 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| contig00633 | 441 | 1945 | yojI | 0/0 | 91.5 | 97.9 | U00096.3:2308615-2306971 | YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00021 | 2698 | 3534 | (AGly)strB | 0/0 | 100.0 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00008 | 6303 | 7607 | (Bla)AmpC1_Ecoli | 0/0 | 100.0 | 95.9 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00673 | 336 | 1469 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 97.9 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00987 | 403 | 1495 | (Bla)ampH_Ecoli | 0/0 | 94.4 | 99.3 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00145 | 105 | 2006 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100.0 | 98.7 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00021 | 4966 | 5781 | (Sul)sul2 | 0/0 | 100.0 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00021 | 3884 | 4357 | (Tmt)dfrA14 | 0/0 | 100.0 | 99.8 | GU726917:72-545 | (Tmt)dfrA14 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00021 | 2698 | 3534 | (AGly)strB | 0/0 | 100.0 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00008 | 6303 | 7607 | (Bla)AmpC1_Ecoli | 0/0 | 100.0 | 95.9 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00673 | 336 | 1469 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 97.9 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00987 | 403 | 1495 | (Bla)ampH_Ecoli | 0/0 | 94.4 | 99.3 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00145 | 105 | 2006 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100.0 | 98.7 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00021 | 4966 | 5781 | (Sul)sul2 | 0/0 | 100.0 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00021 | 3884 | 4357 | (Tmt)dfrA14 | 0/0 | 100.0 | 99.8 | GU726917:72-545 | (Tmt)dfrA14 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig01133 | 197 | 1328 | ACRE | 0/0 | 97.8 | 98.5 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig01150 | 622 | 1284 | ACRS | 0/0 | 100.0 | 97.9 | MEG_415 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:ACRS | NA |
| contig00987 | 403 | 1495 | AMPH | 0/0 | 94.4 | 99.3 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00021 | 2698 | 3534 | APH6 | 0/0 | 100.0 | 100.0 | MEG_1086 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig01389 | 93 | 912 | BACA | 0/0 | 99.8 | 97.3 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00053 | 3396 | 4118 | BAER | 0/0 | 100.0 | 96.3 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00348 | 730 | 1920 | BCR | 0/0 | 100.0 | 96.4 | MEG_1210 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig00673 | 336 | 1469 | BLAEC | 0/0 | 100.0 | 99.2 | MEG_1275 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00788 | 370 | 1068 | CPXAR | 0/0 | 100.0 | 99.4 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00353 | 1924 | 2556 | CRP | 0/0 | 100.0 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00021 | 3884 | 4357 | DFRA | 0/0 | 100.0 | 100.0 | MEG_2517 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig01444 | 36 | 1092 | EMRK | 0/0 | 90.8 | 96.3 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00638 | 1 | 713 | GADW | 0/0 | 97.8 | 96.8 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig01435 | 192 | 1016 | GADX | 0/0 | 100.0 | 93.9 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig01367 | 294 | 683 | MARA | 0/0 | 100.0 | 99.7 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00614 | 154 | 1401 | MDTA | 0/0 | 100.0 | 96.9 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00112 | 571 | 1728 | MDTE | 0/0 | 100.0 | 98.5 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00358 | 720 | 1946 | MDTG | 0/0 | 100.0 | 98.3 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig01088 | 7 | 1239 | MDTM | 0/0 | 100.0 | 96.3 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00138 | 449 | 1480 | MDTN | 0/0 | 100.0 | 97.7 | MEG_3763 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTN | NA |
| contig00138 | 1480 | 3531 | MDTO | 0/0 | 100.0 | 97.0 | MEG_3764 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTO | NA |
| contig00584 | 810 | 1284 | MPHB | 0/0 | 99.6 | 97.0 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00647 | 16 | 348 | MVRC | 0/0 | 100.0 | 91.6 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig00145 | 105 | 2006 | PBP2 | 0/0 | 100.0 | 98.7 | MEG_5400 | Drugs:betalactams:Penicillin_binding_protein:PBP2 | NA |
| contig00008 | 6303 | 7607 | PBP4B | 0/0 | 100.0 | 95.9 | MEG_5409 | Drugs:betalactams:Penicillin_binding_protein:PBP4B | NA |
| contig00404 | 833 | 1801 | PMRF | 0/0 | 100.0 | 96.3 | MEG_5801 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:PMRF | NA |
| contig00096 | 2844 | 3713 | ROBA | 0/0 | 100.0 | 99.1 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig02282 | 379 | 673 | SOXS | 0/0 | 91.0 | 98.0 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00021 | 4966 | 5781 | SULII | 0/0 | 100.0 | 100.0 | MEG_6617 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| contig00633 | 441 | 1945 | YOGI | 0/0 | 91.5 | 97.9 | MEG_7842 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_ABC_efflux_pumps:YOGI | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00071 | 775 | 1578 | aph(3’’)-Ib_5 | 0/0 | 100.0 | 100.0 | AF321551 | aph(3’’)-Ib | Streptomycin |
| contig00071 | 1 | 775 | aph(6)-Id_1 | 0/0 | 92.6 | 100.0 | M28829 | aph(6)-Id | Streptomycin |
| contig00111 | 1903 | 2376 | dfrA5_1 | 0/0 | 100.0 | 99.8 | X12868 | dfrA5 | Trimethoprim |
| contig00111 | 539 | 1405 | sul1_5 | 0/0 | 100.0 | 99.9 | EU780013 | sul1 | Sulfamethoxazole |
| contig00071 | 1639 | 2454 | sul2_2 | 0/0 | 100.0 | 100.0 | AY034138 | sul2 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00071 | 775 | 1578 | APH(3’’)-Ib | 0/0 | 100.0 | 99.8 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig00071 | 2 | 775 | APH(6)-Id | 0/0 | 92.5 | 100.0 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig00157 | 2163 | 2984 | bacA | 0/0 | 100.0 | 99.5 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00035 | 1242 | 1874 | CRP | 0/0 | 100.0 | 99.8 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00111 | 1903 | 2376 | dfrA5 | 0/0 | 100.0 | 99.8 | DQ278190:0-474 | dfrA5 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae | diaminopyrimidine |
| contig00743 | 162 | 1334 | emrA | 0/0 | 100.0 | 100.0 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig01037 | 327 | 1279 | emrK | 0/0 | 90.2 | 99.9 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00259 | 1142 | 2335 | Escherichia_coli_acrA | 0/0 | 100.0 | 100.0 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00042 | 728 | 1861 | Escherichia_coli_ampC | 0/0 | 100.0 | 98.2 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00700 | 345 | 959 | evgA | 0/0 | 100.0 | 100.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00240 | 668 | 1396 | gadW | 0/0 | 100.0 | 94.5 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00419 | 821 | 1204 | marA | 0/0 | 100.0 | 99.7 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00358 | 753 | 1985 | mdtM | 0/0 | 100.0 | 95.8 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00126 | 34 | 2085 | mdtO | 0/0 | 100.0 | 100.0 | AP009048.1:4306557-4304505 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig01213 | 692 | 1151 | mphB | 0/0 | 96.4 | 98.5 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00111 | 539 | 1378 | sul1 | 0/0 | 100.0 | 100.0 | JF969163:1053-1893 | Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons. | sulfonamide |
| contig00071 | 1639 | 2454 | sul2 | 0/0 | 100.0 | 100.0 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig00527 | 358 | 1845 | tolC | 0/0 | 100.0 | 99.7 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00071 | 775 | 1578 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00071 | 1 | 775 | (AGly)strB | 0/0 | 92.6 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00042 | 728 | 1861 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 98.2 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00111 | 539 | 1378 | (Sul)sul1 | 0/0 | 100.0 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig00071 | 1639 | 2454 | (Sul)sul2 | 0/0 | 100.0 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00111 | 1903 | 2376 | (Tmt)dfrA5 | 0/0 | 100.0 | 99.8 | X12868:1306-1779 | (Tmt)dfrA5 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00071 | 775 | 1578 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00071 | 1 | 775 | (AGly)strB | 0/0 | 92.6 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00042 | 728 | 1861 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 98.2 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00111 | 539 | 1378 | (Sul)sul1 | 0/0 | 100.0 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig00071 | 1639 | 2454 | (Sul)sul2 | 0/0 | 100.0 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00111 | 1903 | 2376 | (Tmt)dfrA5 | 0/0 | 100.0 | 99.8 | X12868:1306-1779 | (Tmt)dfrA5 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00259 | 1142 | 2335 | ACRA | 0/0 | 100.0 | 100.0 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00071 | 775 | 1602 | APH3-DPRIME | 0/0 | 100.0 | 100.0 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00071 | 1 | 775 | APH6 | 0/0 | 92.6 | 100.0 | MEG_1086 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig00371 | 365 | 2217 | ASMA | 0/0 | 100.0 | 98.3 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00157 | 2163 | 2984 | BACA | 0/0 | 100.0 | 99.5 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00042 | 728 | 1861 | BLAEC | 0/0 | 100.0 | 98.3 | MEG_1278 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00409 | 707 | 1405 | CPXAR | 0/0 | 100.0 | 99.9 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00035 | 1242 | 1874 | CRP | 0/0 | 100.0 | 99.8 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00111 | 1903 | 2376 | DFRA | 0/0 | 100.0 | 99.8 | MEG_2546 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00743 | 162 | 1334 | EMRA | 0/0 | 100.0 | 100.0 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig00240 | 668 | 1396 | GADW | 0/0 | 100.0 | 99.9 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00419 | 815 | 1204 | MARA | 0/0 | 100.0 | 99.7 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00419 | 367 | 801 | MARR | 0/0 | 100.0 | 97.9 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00941 | 964 | 1293 | MDTI | 0/0 | 100.0 | 99.7 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00941 | 612 | 977 | MDTJ | 0/0 | 100.0 | 99.2 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00358 | 753 | 1985 | MDTM | 0/0 | 100.0 | 95.8 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00126 | 34 | 2085 | MDTO | 0/0 | 100.0 | 100.0 | MEG_3764 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTO | NA |
| contig01213 | 692 | 1151 | MPHB | 0/0 | 96.4 | 98.5 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00452 | 1211 | 2024 | ROBA | 0/0 | 93.6 | 98.9 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00394 | 951 | 1273 | SOXS | 0/0 | 99.7 | 99.7 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00111 | 412 | 1379 | SULI | 0/0 | 100.0 | 100.0 | MEG_6615 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULI | NA |
| contig00071 | 1639 | 2454 | SULII | 0/0 | 100.0 | 100.0 | MEG_6617 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00039 | 4060 | 4863 | aph(3’’)-Ib_5 | 0/0 | 100 | 100.0 | AF321551 | aph(3’’)-Ib | Streptomycin |
| contig00039 | 3224 | 4060 | aph(6)-Id_1 | 0/0 | 100 | 99.9 | M28829 | aph(6)-Id | Streptomycin |
| contig00743 | 580 | 1089 | dfrA8_1 | 0/0 | 100 | 100.0 | U10186 | dfrA8 | Trimethoprim |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00445 | 1 | 1043 | acrE | 0/0 | 90.1 | 97.7 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00039 | 4060 | 4863 | APH(3’’)-Ib | 0/0 | 100.0 | 99.8 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig00039 | 3224 | 4060 | APH(6)-Id | 0/0 | 100.0 | 99.8 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig00776 | 653 | 1472 | bacA | 0/0 | 99.8 | 94.8 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00533 | 577 | 1298 | baeR | 0/0 | 99.9 | 96.1 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00401 | 1022 | 2395 | cpxA | 0/0 | 100.0 | 96.1 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00052 | 1936 | 2568 | CRP | 0/0 | 100.0 | 98.9 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00743 | 580 | 1089 | dfrA8 | 0/0 | 100.0 | 100.0 | KJ174469:710-1220 | dfrA8 is a transposon-encoded dihydrofolate reductase found in Salmonella enterica | diaminopyrimidine |
| contig01487 | 150 | 764 | evgA | 0/0 | 100.0 | 98.7 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00592 | 98 | 826 | gadW | 0/0 | 100.0 | 94.2 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig01565 | 162 | 950 | gadX | 0/0 | 95.6 | 95.7 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00705 | 970 | 1353 | marA | 0/0 | 100.0 | 99.7 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00738 | 215 | 1462 | mdtA | 0/0 | 100.0 | 94.5 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig01017 | 324 | 1402 | mdtE | 0/0 | 93.2 | 97.2 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00980 | 1 | 1155 | mdtM | 0/0 | 93.7 | 97.8 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00491 | 1331 | 1805 | mphB | 0/0 | 99.6 | 96.8 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00422 | 422 | 2170 | msbA | 0/0 | 100.0 | 97.9 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| contig00826 | 1 | 737 | sul2 | 0/0 | 90.3 | 100.0 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig00387 | 351 | 1838 | tolC | 0/0 | 100.0 | 97.0 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00039 | 4060 | 4863 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00039 | 3224 | 4060 | (AGly)strB | 0/0 | 100.0 | 99.9 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00826 | 1 | 737 | (Sul)sul2 | 0/0 | 90.3 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00743 | 580 | 1089 | (Tmt)dfrA8 | 0/0 | 100.0 | 100.0 | U10186:711-1220 | (Tmt)dfrA8 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00039 | 4060 | 4863 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00039 | 3224 | 4060 | (AGly)strB | 0/0 | 100.0 | 99.9 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00826 | 1 | 737 | (Sul)sul2 | 0/0 | 90.3 | 100.0 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00743 | 580 | 1089 | (Tmt)dfrA8 | 0/0 | 100.0 | 100.0 | U10186:711-1220 | (Tmt)dfrA8 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00445 | 1 | 1043 | ACRE | 0/0 | 90.1 | 97.7 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig00039 | 4060 | 4887 | APH3-DPRIME | 0/0 | 100.0 | 100.0 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00039 | 3224 | 4060 | APH6 | 0/0 | 100.0 | 100.0 | MEG_1084 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig00776 | 653 | 1472 | BACA | 0/0 | 99.8 | 95.0 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00533 | 577 | 1298 | BAER | 0/0 | 99.9 | 96.1 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00401 | 327 | 1025 | CPXAR | 0/0 | 100.0 | 99.0 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00401 | 1022 | 2395 | CPXAR | 0/0 | 100.0 | 96.4 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00052 | 1936 | 2568 | CRP | 0/0 | 100.0 | 98.9 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00743 | 580 | 1089 | DFRA | 0/0 | 100.0 | 100.0 | MEG_2553 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00592 | 98 | 826 | GADW | 0/0 | 100.0 | 95.5 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig01565 | 162 | 950 | GADX | 0/0 | 95.6 | 95.7 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00705 | 970 | 1359 | MARA | 0/0 | 100.0 | 99.7 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00705 | 1374 | 1770 | MARR | 0/0 | 91.3 | 97.7 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00738 | 215 | 1462 | MDTA | 0/0 | 100.0 | 94.5 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig01017 | 324 | 1402 | MDTE | 0/0 | 93.2 | 97.2 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00328 | 243 | 572 | MDTI | 0/0 | 100.0 | 93.9 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig00404 | 651 | 2024 | MDTK | 0/0 | 100.0 | 97.0 | MEG_3759 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MATE_efflux_pumps:MDTK | NA |
| contig00980 | 1 | 1155 | MDTM | 0/0 | 93.7 | 97.8 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00491 | 1331 | 1805 | MPHB | 0/0 | 99.6 | 96.8 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00422 | 422 | 2170 | MSBA | 0/0 | 100.0 | 97.9 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
| contig00440 | 1427 | 2280 | ROBA | 0/0 | 98.2 | 97.2 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig01213 | 763 | 1085 | SOXS | 0/0 | 99.7 | 97.2 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00826 | 1 | 737 | SULII | 0/0 | 90.3 | 100.0 | MEG_6617 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00038 | 1270 | 2073 | aph(3’’)-Ib_5 | 0/0 | 100.0 | 100.0 | AF321551 | aph(3’’)-Ib | Streptomycin |
| contig00038 | 434 | 1270 | aph(6)-Id_1 | 0/0 | 100.0 | 100.0 | M28829 | aph(6)-Id | Streptomycin |
| contig00410 | 1 | 858 | blaTEM-1B_1 | 0/0 | 99.7 | 100.0 | AY458016 | blaTEM-1B | Amoxicillin, Ampicillin, Cephalothin, Piperacillin, Ticarcillin |
| contig00090 | 2744 | 3217 | dfrA1_10 | 0/0 | 100.0 | 99.8 | AF203818 | dfrA1 | Trimethoprim |
| contig00090 | 516 | 1382 | sul1_5 | 0/0 | 100.0 | 99.9 | EU780013 | sul1 | Sulfamethoxazole |
| contig00038 | 2134 | 2949 | sul2_3 | 0/0 | 100.0 | 100.0 | HQ840942 | sul2 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00456 | 816 | 1973 | acrE | 0/0 | 100.0 | 98.9 | U00096:3413863-3415021 | AcrE is a membrane fusion protein similar to AcrA. | cephalosporin, cephamycin, fluoroquinolone, penam |
| contig00038 | 1270 | 2073 | APH(3’’)-Ib | 0/0 | 100.0 | 99.8 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig00038 | 434 | 1270 | APH(6)-Id | 0/0 | 100.0 | 99.9 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig00135 | 2152 | 2784 | CRP | 0/0 | 100.0 | 99.8 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00090 | 2744 | 3217 | dfrA1 | 0/0 | 100.0 | 100.0 | KJ541681.1:19526-20000 | dfrA1 is an integron-encoded dihydrofolate reductase | diaminopyrimidine |
| contig00085 | 1551 | 2684 | Escherichia_coli_ampC | 0/0 | 100.0 | 97.3 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig02179 | 182 | 514 | Escherichia_coli_emrE | 0/0 | 100.0 | 92.2 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig00990 | 1 | 614 | evgA | 0/0 | 99.8 | 100.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00969 | 1 | 797 | gadX | 0/0 | 96.6 | 100.0 | AP009048.1:3974604-3975429 | GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. | fluoroquinolone, macrolide, penam |
| contig00148 | 816 | 1229 | H-NS | 0/0 | 100.0 | 99.5 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00060 | 2447 | 3604 | mdtE | 0/0 | 100.0 | 100.0 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00341 | 243 | 1454 | mdtM | 0/0 | 98.3 | 95.9 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00846 | 1 | 1446 | mdtP | 0/0 | 98.6 | 99.9 | AP009048.1:4304509-4303042 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00090 | 516 | 1355 | sul1 | 0/0 | 100.0 | 100.0 | JF969163:1053-1893 | Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons. | sulfonamide |
| contig00038 | 2134 | 2949 | sul2 | 0/0 | 100.0 | 99.6 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig00410 | 1 | 858 | TEM-1 | 0/0 | 99.7 | 99.9 | AL513383:161910-162771 | TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. | cephalosporin, monobactam, penam, penem |
| contig00142 | 407 | 1573 | ugd | 0/0 | 100.0 | 97.4 | U00096:2099613-2098446 | PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin | peptide |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00090 | 1860 | 2661 | (AGly)aadA1-pm | 0/0 | 96.5 | 99.9 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00038 | 1270 | 2073 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00038 | 434 | 1270 | (AGly)strB | 0/0 | 100.0 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00085 | 1551 | 2684 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 97.3 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00410 | 1 | 858 | (Bla)blaTEM-105 | 0/0 | 99.7 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00090 | 516 | 1355 | (Sul)sul1 | 0/0 | 100.0 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig00038 | 2134 | 2949 | (Sul)sul2 | 0/0 | 100.0 | 99.6 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig01088 | 10 | 660 | (Tet)tetR | 0/0 | 100.0 | 100.0 | HF545434:53576-54226 | (Tet)tetR | NA |
| contig00090 | 2744 | 3217 | (Tmt)dfrA1 | 0/0 | 100.0 | 99.8 | JQ794607:474 | (Tmt)dfrA1 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00090 | 1860 | 2661 | (AGly)aadA1-pm | 0/0 | 96.5 | 99.9 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00038 | 1270 | 2073 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00038 | 434 | 1270 | (AGly)strB | 0/0 | 100.0 | 100.0 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00085 | 1551 | 2684 | (Bla)AmpC2_Ecoli | 0/0 | 100.0 | 97.3 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00410 | 1 | 858 | (Bla)blaTEM-105 | 0/0 | 99.7 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00090 | 516 | 1355 | (Sul)sul1 | 0/0 | 100.0 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig00038 | 2134 | 2949 | (Sul)sul2 | 0/0 | 100.0 | 99.6 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig01088 | 10 | 660 | (Tet)tetR | 0/0 | 100.0 | 100.0 | HF545434:53576-54226 | (Tet)tetR | NA |
| contig00090 | 2744 | 3217 | (Tmt)dfrA1 | 0/0 | 100.0 | 99.8 | JQ794607:474 | (Tmt)dfrA1 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00456 | 816 | 1973 | ACRE | 0/0 | 100.0 | 98.9 | MEG_408 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRE | NA |
| contig00090 | 1860 | 2661 | ANT3-DPRIME | 0/0 | 96.5 | 99.9 | MEG_915 | Drugs:Aminoglycosides:Aminoglycoside_O-nucleotidyltransferases:ANT3-DPRIME | NA |
| contig00038 | 1270 | 2097 | APH3-DPRIME | 0/0 | 100.0 | 100.0 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00038 | 434 | 1270 | APH6 | 0/0 | 100.0 | 100.0 | MEG_1086 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig00455 | 216 | 2068 | ASMA | 0/0 | 100.0 | 98.1 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00085 | 1551 | 2684 | BLAEC | 0/0 | 100.0 | 98.6 | MEG_1282 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00581 | 520 | 1218 | CPXAR | 0/0 | 100.0 | 99.6 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00135 | 2152 | 2784 | CRP | 0/0 | 100.0 | 99.8 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00090 | 2744 | 3217 | DFRA | 0/0 | 100.0 | 99.8 | MEG_2528 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00969 | 1 | 797 | GADX | 0/0 | 96.6 | 100.0 | MEG_3083 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADX | NA |
| contig00148 | 816 | 1229 | HNS | 0/0 | 100.0 | 99.5 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig02114 | 154 | 588 | MARR | 0/0 | 100.0 | 99.1 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00060 | 2447 | 3604 | MDTE | 0/0 | 100.0 | 100.0 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig02382 | 1 | 345 | MDTJ | 0/0 | 94.3 | 98.8 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00341 | 243 | 1454 | MDTM | 0/0 | 98.3 | 95.9 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00846 | 1 | 1446 | MDTP | 0/0 | 98.6 | 99.9 | MEG_3765 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTP | NA |
| contig02179 | 182 | 514 | MVRC | 0/0 | 100.0 | 92.2 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig00440 | 230 | 553 | SOXS | 0/0 | 100.0 | 100.0 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00090 | 389 | 1356 | SULI | 0/0 | 100.0 | 100.0 | MEG_6615 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULI | NA |
| contig00038 | 2134 | 2949 | SULII | 0/0 | 100.0 | 100.0 | MEG_6618 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| contig00410 | 1 | 1225 | TEM | 0/0 | 96.6 | 99.3 | MEG_6875 | Drugs:betalactams:Class_A_betalactamases:TEM | NA |
| contig00142 | 407 | 1573 | UGD | 0/0 | 100.0 | 97.4 | MEG_7328 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:UGD | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00270 | 826 | 1629 | aph(3’’)-Ib_5 | 0/0 | 100.0 | 100.0 | AF321551 | aph(3’’)-Ib | Streptomycin |
| contig00270 | 1 | 826 | aph(6)-Id_1 | 0/0 | 98.7 | 99.9 | M28829 | aph(6)-Id | Streptomycin |
| contig00169 | 2410 | 2883 | dfrA1_10 | 0/0 | 100.0 | 99.8 | AF203818 | dfrA1 | Trimethoprim |
| contig00169 | 182 | 1048 | sul1_5 | 0/0 | 100.0 | 99.9 | EU780013 | sul1 | Sulfamethoxazole |
| contig00270 | 1690 | 2505 | sul2_3 | 0/0 | 100.0 | 100.0 | HQ840942 | sul2 | Sulfamethoxazole |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00004 | 5503 | 8652 | acrB | 0/0 | 100.0 | 99.0 | U00096.3:484403-481253 | Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00270 | 826 | 1629 | APH(3’’)-Ib | 0/0 | 100.0 | 99.8 | AF313472:15593-16397 | APH(3’’)-Ib is an aminoglycoside phosphotransferase encoded by plasmids transposons integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. | aminoglycoside |
| contig00270 | 1 | 826 | APH(6)-Id | 0/0 | 98.7 | 99.8 | AF024602:3155-3992 | APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids integrative conjugative elements and chromosomal genomic islands in K. pneumoniae Salmonella spp. E. coli Shigella flexneri Providencia alcalifaciens Pseudomonas spp. V. cholerae Edwardsiella tarda Pasteurella multocida and Aeromonas bestiarum | aminoglycoside |
| contig01596 | 273 | 994 | baeR | 0/0 | 99.9 | 98.2 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00349 | 1117 | 2489 | cpxA | 0/0 | 99.9 | 97.8 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig01145 | 649 | 1281 | CRP | 0/0 | 100.0 | 99.0 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig00169 | 2410 | 2883 | dfrA1 | 0/0 | 100.0 | 100.0 | KJ541681.1:19526-20000 | dfrA1 is an integron-encoded dihydrofolate reductase | diaminopyrimidine |
| contig00533 | 672 | 1727 | emrK | 0/0 | 100.0 | 97.0 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig02108 | 117 | 647 | emrR | 0/0 | 100.0 | 99.4 | U00096.3:2810769-2811300 | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | fluoroquinolone |
| contig00002 | 4973 | 6130 | Escherichia_coli_ampH | 0/0 | 100.0 | 96.7 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig01113 | 126 | 740 | evgA | 0/0 | 100.0 | 99.2 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig00101 | 1032 | 1760 | gadW | 0/0 | 100.0 | 95.8 | CP015085.1:2552440-2551711 | GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC. | fluoroquinolone, macrolide, penam |
| contig00658 | 1457 | 1849 | H-NS | 0/0 | 94.9 | 99.5 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00793 | 739 | 1122 | marA | 0/0 | 100.0 | 99.7 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00439 | 180 | 1427 | mdtA | 0/0 | 100.0 | 97.4 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00266 | 530 | 1687 | mdtE | 0/0 | 100.0 | 98.5 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00596 | 1 | 1201 | mdtG | 0/0 | 97.9 | 97.8 | CP000800.1:1192954-1191727 | The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. | fosfomycin |
| contig00505 | 597 | 1805 | mdtH | 0/0 | 100.0 | 98.2 | U00096:1125326-1124117 | Multidrug resistance protein MdtH | fluoroquinolone |
| contig00485 | 734 | 1966 | mdtM | 0/0 | 100.0 | 95.0 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00381 | 1 | 2008 | mdtO | 0/0 | 97.9 | 96.7 | AP009048.1:4306557-4304505 | Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride | acridine_dye, nucleoside |
| contig00033 | 277 | 753 | mphB | 0/0 | 100.0 | 97.9 | AE005174.2:3397370-3397847 | The mphB gene encodes for MPH(2’)-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2’-OH hydroxyl of desosamine sugar of macrolides. | macrolide |
| contig00169 | 182 | 1021 | sul1 | 0/0 | 100.0 | 100.0 | JF969163:1053-1893 | Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons. | sulfonamide |
| contig00270 | 1690 | 2505 | sul2 | 0/0 | 100.0 | 99.6 | AY055428.1:21084-20268 | Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria usually found on small plasmids. | sulfonamide |
| contig00324 | 469 | 1956 | tolC | 0/0 | 100.0 | 98.5 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00169 | 1526 | 2327 | (AGly)aadA1-pm | 0/0 | 96.5 | 99.9 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00270 | 826 | 1629 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00270 | 1 | 826 | (AGly)strB | 0/0 | 98.7 | 99.9 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00002 | 4973 | 6130 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 96.7 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00169 | 182 | 1021 | (Sul)sul1 | 0/0 | 100.0 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig00270 | 1690 | 2505 | (Sul)sul2 | 0/0 | 100.0 | 99.6 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00169 | 2410 | 2883 | (Tmt)dfrA1 | 0/0 | 100.0 | 99.8 | JQ794607:474 | (Tmt)dfrA1 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00169 | 1526 | 2327 | (AGly)aadA1-pm | 0/0 | 96.5 | 99.9 | JQ690540:7968-8798 | (AGly)aadA1-pm | NA |
| contig00270 | 826 | 1629 | (AGly)strA | 0/0 | 100.0 | 99.9 | AB366441:22458-23261 | (AGly)strA | NA |
| contig00270 | 1 | 826 | (AGly)strB | 0/0 | 98.7 | 99.9 | FJ474091:264-1100 | (AGly)strB | NA |
| contig00002 | 4973 | 6130 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 96.7 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00169 | 182 | 1021 | (Sul)sul1 | 0/0 | 100.0 | 100.0 | AF071413:6700-7539 | (Sul)sul1 | NA |
| contig00270 | 1690 | 2505 | (Sul)sul2 | 0/0 | 100.0 | 99.6 | EU360945:1617-2432 | (Sul)sul2 | NA |
| contig00169 | 2410 | 2883 | (Tmt)dfrA1 | 0/0 | 100.0 | 99.8 | JQ794607:474 | (Tmt)dfrA1 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00004 | 5503 | 8652 | ACRB | 0/0 | 100.0 | 99.0 | MEG_401 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRB | NA |
| contig00002 | 4973 | 6130 | AMPH | 0/0 | 100.0 | 96.7 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00169 | 1526 | 2327 | ANT3-DPRIME | 0/0 | 96.5 | 99.9 | MEG_915 | Drugs:Aminoglycosides:Aminoglycoside_O-nucleotidyltransferases:ANT3-DPRIME | NA |
| contig00270 | 826 | 1653 | APH3-DPRIME | 0/0 | 100.0 | 100.0 | MEG_1019 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH3-DPRIME | NA |
| contig00270 | 1 | 826 | APH6 | 0/0 | 98.7 | 100.0 | MEG_1084 | Drugs:Aminoglycosides:Aminoglycoside_O-phosphotransferases:APH6 | NA |
| contig01596 | 273 | 994 | BAER | 0/0 | 99.9 | 98.2 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00349 | 422 | 1120 | CPXAR | 0/0 | 100.0 | 99.6 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00349 | 1117 | 2489 | CPXAR | 0/0 | 99.9 | 98.1 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig01145 | 649 | 1281 | CRP | 0/0 | 100.0 | 99.0 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00169 | 2410 | 2883 | DFRA | 0/0 | 100.0 | 99.8 | MEG_2528 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00533 | 672 | 1835 | EMRK | 0/0 | 100.0 | 97.2 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig02108 | 117 | 647 | EMRR | 0/0 | 100.0 | 99.4 | MEG_2734 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_regulator:EMRR | NA |
| contig00101 | 1032 | 1760 | GADW | 0/0 | 100.0 | 97.4 | MEG_3081 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:GADW | NA |
| contig00658 | 1457 | 1849 | HNS | 0/0 | 94.9 | 99.5 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00793 | 733 | 1122 | MARA | 0/0 | 100.0 | 99.7 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00793 | 285 | 719 | MARR | 0/0 | 100.0 | 98.4 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00439 | 180 | 1427 | MDTA | 0/0 | 100.0 | 97.4 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00266 | 530 | 1687 | MDTE | 0/0 | 100.0 | 98.5 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig00596 | 1 | 1201 | MDTG | 0/0 | 97.9 | 98.0 | MEG_3753 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTG | NA |
| contig00505 | 597 | 1805 | MDTH | 0/0 | 100.0 | 98.2 | MEG_3755 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTH | NA |
| contig01603 | 1 | 306 | MDTI | 0/0 | 92.7 | 99.7 | MEG_3756 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTI | NA |
| contig01603 | 293 | 658 | MDTJ | 0/0 | 100.0 | 98.4 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00485 | 734 | 1966 | MDTM | 0/0 | 100.0 | 95.0 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00381 | 1 | 2008 | MDTO | 0/0 | 97.9 | 96.7 | MEG_3764 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTO | NA |
| contig00033 | 277 | 753 | MPHB | 0/0 | 100.0 | 97.9 | MEG_4033 | Drugs:MLS:Macrolide_phosphotransferases:MPHB | NA |
| contig00450 | 828 | 1697 | ROBA | 0/0 | 100.0 | 99.3 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig01014 | 67 | 389 | SOXS | 0/0 | 99.7 | 98.1 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00169 | 55 | 1022 | SULI | 0/0 | 100.0 | 100.0 | MEG_6615 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULI | NA |
| contig00270 | 1690 | 2505 | SULII | 0/0 | 100.0 | 100.0 | MEG_6618 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULII | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00088 | 3942 | 4802 | blaTEM-1B_1 | 0/0 | 100.0 | 100.0 | AY458016 | blaTEM-1B | Amoxicillin, Ampicillin, Cephalothin, Piperacillin, Ticarcillin |
| contig00839 | 236 | 1495 | cmlA1_1 | 0/0 | 100.0 | 99.8 | M64556 | cmlA1 | Chloramphenicol |
| contig01298 | 683 | 1180 | dfrA12_8 | 0/0 | 100.0 | 100.0 | AM040708 | dfrA12 | Trimethoprim |
| contig00016 | 1123 | 1914 | sul3_2 | 0/0 | 100.0 | 99.9 | AJ459418 | sul3 | Sulfamethoxazole |
| contig00228 | 1476 | 2722 | tet(A)_6 | 0/0 | 97.8 | 99.9 | AF534183 | tet(A) | Doxycycline, Tetracycline |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00309 | 145 | 3063 | acrB | 0/0 | 92.7 | 99.1 | U00096.3:484403-481253 | Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00198 | 30 | 851 | bacA | 0/0 | 100.0 | 98.9 | U00096.3:3204131-3203309 | The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. | peptide |
| contig00617 | 193 | 915 | baeR | 0/0 | 100.0 | 99.3 | AP009048.1:2166412-2167135 | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | aminocoumarin, aminoglycoside |
| contig00839 | 236 | 1495 | cmlA1 | 0/0 | 100.0 | 99.8 | M64556.1:600-1860 | cmlA1 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa and Klebsiella pneumoniae | phenicol |
| contig00086 | 3577 | 4950 | cpxA | 0/0 | 100.0 | 98.8 | BA000007.3:4905062-4903688 | CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression. | aminocoumarin, aminoglycoside |
| contig00389 | 995 | 1627 | CRP | 0/0 | 100.0 | 99.2 | AP009048.1:4154296-4153663 | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | fluoroquinolone, macrolide, penam |
| contig01298 | 683 | 1180 | dfrA12 | 0/0 | 100.0 | 100.0 | GU585907.1:22103-21605 | dfrA12 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae | diaminopyrimidine |
| contig00331 | 122 | 1294 | emrA | 0/0 | 100.0 | 98.2 | AP009048:2810082-2811255 | EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium. | fluoroquinolone |
| contig00331 | 1311 | 2849 | emrB | 0/0 | 100.0 | 98.8 | U00096:2812615-2814154 | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin. | fluoroquinolone |
| contig00147 | 704 | 1759 | emrK | 0/0 | 100.0 | 99.7 | D78168:536-1592 | emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux. | tetracycline |
| contig00006 | 2390 | 4033 | eptA | 0/0 | 100.0 | 99.4 | AP009048:4340268-4338624 | PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B. | peptide |
| contig00640 | 208 | 1401 | Escherichia_coli_acrA | 0/0 | 100.0 | 99.8 | U00096.3:485619-484425 | AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli. | cephalosporin, fluoroquinolone, glycylcycline, penam, phenicol, rifamycin, tetracycline, triclosan |
| contig00907 | 591 | 1655 | Escherichia_coli_ampC | 0/0 | 93.9 | 97.8 | U00096.3:4378944-4377810 | A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. | cephalosporin, penam |
| contig00618 | 145 | 1449 | Escherichia_coli_ampC1_beta-lactamase | 0/0 | 100.0 | 98.2 | FN649414.1:2765050-2766355 | An ampC-like beta-lactamase identified from Escherichia coli. | cephalosporin, penam |
| contig00373 | 1283 | 2440 | Escherichia_coli_ampH | 0/0 | 100.0 | 98.8 | AP012030.1:396711-395553 | AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli. | cephalosporin, penam |
| contig00109 | 1761 | 2093 | Escherichia_coli_emrE | 0/0 | 100.0 | 92.2 | Z11877.1:485-818 | Member of the small MDR (multidrug resistance) family of transporters, in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin, proton-dependent secondary transporter which exchanges protons for compound translocation | macrolide |
| contig00147 | 2283 | 2897 | evgA | 0/0 | 100.0 | 99.0 | BA000007.3:3212025-3212640 | EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed. | fluoroquinolone, macrolide, penam, tetracycline |
| contig01782 | 86 | 499 | H-NS | 0/0 | 100.0 | 99.0 | BA000007.3:1738104-1737690 | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters. | cephalosporin, cephamycin, fluoroquinolone, macrolide, penam, tetracycline |
| contig00452 | 1532 | 1915 | marA | 0/0 | 100.0 | 99.5 | AP009048.1:1621287-1621671 | In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF. | carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, monobactam, penam, penem, phenicol, rifamycin, tetracycline, triclosan |
| contig00764 | 117 | 1364 | mdtA | 0/0 | 100.0 | 98.2 | U00096:2154015-2155263 | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | aminocoumarin |
| contig00346 | 571 | 1728 | mdtE | 0/0 | 100.0 | 99.7 | AP009048.1:3981183-3980025 | MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. | fluoroquinolone, macrolide, penam |
| contig00571 | 296 | 1528 | mdtM | 0/0 | 100.0 | 95.5 | U00096.3:4568519-4567286 | Multidrug resistance protein MdtM | acridine_dye, fluoroquinolone, lincosamide, nucleoside, phenicol |
| contig00189 | 70 | 1818 | msbA | 0/0 | 100.0 | 99.0 | U00096.3:966620-968369 | MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability. | nitroimidazole |
| contig02346 | 23 | 355 | qacH | 0/0 | 100.0 | 91.6 | DQ149925.1:188-521 | qacH is a subunit of the qac multidrug efflux pump in Vibrio cholerae | fluoroquinolone |
| contig00016 | 1123 | 1914 | sul3 | 0/0 | 100.0 | 99.9 | FJ196385:9323-8531 | Sul3 is a sulfonamide resistant dihydropteroate synthase similar to Sul1 and Sul2. Its resistance gene was found encoded in E. coli plasmid DNA of sulfonamide resistant isolates. | sulfonamide |
| contig00088 | 3942 | 4802 | TEM-1 | 0/0 | 100.0 | 99.9 | AL513383:161910-162771 | TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. | cephalosporin, monobactam, penam, penem |
| contig00228 | 1476 | 2722 | tet(A) | 0/0 | 97.8 | 99.9 | AF534183.1:2970-4245 | TetA is a tetracycline efflux pump found in many species of Gram-negative bacteria. | tetracycline |
| contig00005 | 3313 | 4800 | tolC | 0/0 | 100.0 | 98.5 | FJ768952:0-1488 | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | aminocoumarin, aminoglycoside, carbapenem, cephalosporin, cephamycin, fluoroquinolone, glycylcycline, macrolide, penam, penem, peptide, phenicol, rifamycin, tetracycline, triclosan |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00618 | 145 | 1449 | (Bla)AmpC1_Ecoli | 0/0 | 100.0 | 98.2 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00907 | 591 | 1655 | (Bla)AmpC2_Ecoli | 0/0 | 93.9 | 97.8 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00373 | 1283 | 2440 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 98.8 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00088 | 3942 | 4802 | (Bla)blaTEM-105 | 0/0 | 100.0 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00069 | 1969 | 3870 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100.0 | 99.0 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00839 | 236 | 1495 | (Phe)cmlA1 | 0/0 | 100.0 | 99.8 | M64556:601-1860 | (Phe)cmlA1 | NA |
| contig00016 | 1123 | 1914 | (Sul)sul3 | 0/0 | 100.0 | 99.9 | HQ875016:7396-8187 | (Sul)sul3 | NA |
| contig00228 | 1448 | 2722 | (Tet)tetA | 0/0 | 100.0 | 99.9 | JX424423:94438-95712 | (Tet)tetA | NA |
| contig00228 | 2753 | 3403 | (Tet)tetR | 0/0 | 100.0 | 99.8 | HF545434:53576-54226 | (Tet)tetR | NA |
| contig01298 | 683 | 1180 | (Tmt)dfrA12 | 0/0 | 100.0 | 100.0 | Z21672:310-807 | (Tmt)dfrA12 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00618 | 145 | 1449 | (Bla)AmpC1_Ecoli | 0/0 | 100.0 | 98.2 | FN649414:2765051-2766355 | (Bla)AmpC1_Ecoli | NA |
| contig00907 | 591 | 1655 | (Bla)AmpC2_Ecoli | 0/0 | 93.9 | 97.8 | CP002970:332756-333889 | (Bla)AmpC2_Ecoli | NA |
| contig00373 | 1283 | 2440 | (Bla)ampH_Ecoli | 0/0 | 100.0 | 98.8 | AP012030:395554-396711 | (Bla)ampH_Ecoli | NA |
| contig00088 | 3942 | 4802 | (Bla)blaTEM-105 | 0/0 | 100.0 | 99.9 | AF516720:215-1075 | (Bla)blaTEM-105 | NA |
| contig00069 | 1969 | 3870 | (Bla)Penicillin_Binding_Protein_Ecoli | 0/0 | 100.0 | 99.0 | CP002291:664439-666340 | (Bla)Penicillin_Binding_Protein_Ecoli | NA |
| contig00839 | 236 | 1495 | (Phe)cmlA1 | 0/0 | 100.0 | 99.8 | M64556:601-1860 | (Phe)cmlA1 | NA |
| contig00016 | 1123 | 1914 | (Sul)sul3 | 0/0 | 100.0 | 99.9 | HQ875016:7396-8187 | (Sul)sul3 | NA |
| contig00228 | 1448 | 2722 | (Tet)tetA | 0/0 | 100.0 | 99.9 | JX424423:94438-95712 | (Tet)tetA | NA |
| contig00228 | 2753 | 3403 | (Tet)tetR | 0/0 | 100.0 | 99.8 | HF545434:53576-54226 | (Tet)tetR | NA |
| contig01298 | 683 | 1180 | (Tmt)dfrA12 | 0/0 | 100.0 | 100.0 | Z21672:310-807 | (Tmt)dfrA12 | NA |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product | Resistance |
|---|---|---|---|---|---|---|---|---|---|
| contig00640 | 208 | 1401 | ACRA | 0/0 | 100.0 | 99.8 | MEG_399 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRA | NA |
| contig00309 | 145 | 3063 | ACRB | 0/0 | 92.7 | 99.1 | MEG_401 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:ACRB | NA |
| contig00373 | 1283 | 2440 | AMPH | 0/0 | 100.0 | 98.8 | MEG_729 | Drugs:betalactams:Penicillin_binding_protein:AMPH | NA |
| contig00789 | 1 | 1834 | ASMA | 0/0 | 98.9 | 98.4 | MEG_1180 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_regulator:ASMA | NA |
| contig00198 | 30 | 851 | BACA | 0/0 | 100.0 | 98.9 | MEG_1189 | Drugs:Bacitracin:Undecaprenyl_pyrophosphate_phosphatase:BACA | NA |
| contig00617 | 193 | 915 | BAER | 0/0 | 100.0 | 99.3 | MEG_1192 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_regulator:BAER | NA |
| contig00540 | 1 | 1116 | BCR | 0/0 | 98.4 | 96.5 | MEG_1209 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:BCR | NA |
| contig00907 | 591 | 1655 | BLAEC | 0/0 | 93.9 | 100.0 | MEG_1279 | Drugs:betalactams:Class_C_betalactamases:BLAEC | NA |
| contig00839 | 35 | 1495 | CMLA | 1/1 | 100.0 | 99.7 | MEG_1768 | Drugs:Phenicol:Phenicol_resistance_MFS_efflux_pumps:CMLA | NA |
| contig00086 | 2882 | 3580 | CPXAR | 0/0 | 100.0 | 99.6 | MEG_2118 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00086 | 3577 | 4950 | CPXAR | 0/0 | 100.0 | 99.4 | MEG_2121 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CPXAR | NA |
| contig00389 | 995 | 1627 | CRP | 0/0 | 100.0 | 99.2 | MEG_2132 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:CRP | NA |
| contig00796 | 1 | 872 | CTX | 0/0 | 98.1 | 95.3 | MEG_2430 | Drugs:betalactams:Class_A_betalactamases:CTX | NA |
| contig01298 | 683 | 1180 | DFRA | 0/0 | 100.0 | 100.0 | MEG_2551 | Drugs:Trimethoprim:Dihydrofolate_reductase:DFRA | NA |
| contig00331 | 122 | 1294 | EMRA | 0/0 | 100.0 | 98.2 | MEG_2722 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRA | NA |
| contig00331 | 1311 | 2849 | EMRB | 0/0 | 100.0 | 98.8 | MEG_2725 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRB | NA |
| contig00147 | 704 | 1867 | EMRK | 0/0 | 100.0 | 99.7 | MEG_2732 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:EMRK | NA |
| contig00006 | 2390 | 4033 | EPTA | 0/0 | 100.0 | 99.4 | MEG_2739 | Drugs:Cationic_antimicrobial_peptides:Lipid_A_modification:EPTA | NA |
| contig01782 | 86 | 499 | HNS | 0/0 | 100.0 | 99.0 | MEG_3271 | Drugs:Multi-drug_resistance:Multi-drug_RND_efflux_pumps:HNS | NA |
| contig00452 | 1526 | 1915 | MARA | 0/0 | 100.0 | 99.5 | MEG_3662 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARA | NA |
| contig00452 | 1078 | 1512 | MARR | 0/0 | 100.0 | 97.7 | MEG_3663 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_regulator:MARR | NA |
| contig00764 | 117 | 1364 | MDTA | 0/0 | 100.0 | 98.2 | MEG_3746 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:MDTA | NA |
| contig00346 | 571 | 1728 | MDTE | 0/0 | 100.0 | 99.7 | MEG_3751 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_RND_efflux_pumps:MDTE | NA |
| contig01876 | 130 | 495 | MDTJ | 0/0 | 100.0 | 99.7 | MEG_3757 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MDTJ | NA |
| contig00571 | 296 | 1528 | MDTM | 0/0 | 100.0 | 95.5 | MEG_3761 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_MFS_efflux_pumps:MDTM | NA |
| contig00189 | 70 | 1818 | MSBA | 0/0 | 100.0 | 99.0 | MEG_4061 | Drugs:Multi-drug_resistance:Multi-drug_ABC_efflux_pumps:MSBA | NA |
| contig00109 | 1761 | 2093 | MVRC | 0/0 | 100.0 | 92.2 | MEG_4103 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:MVRC | NA |
| contig00069 | 1969 | 3870 | PBP2 | 0/0 | 100.0 | 99.0 | MEG_5400 | Drugs:betalactams:Penicillin_binding_protein:PBP2 | NA |
| contig00618 | 145 | 1449 | PBP4B | 0/0 | 100.0 | 98.2 | MEG_5409 | Drugs:betalactams:Penicillin_binding_protein:PBP4B | NA |
| contig02346 | 23 | 355 | QACL | 0/0 | 100.0 | 100.0 | MEG_5852 | Multi-compound:Drug_and_biocide_resistance:Drug_and_biocide_SMR_efflux_pumps:QACL | NA |
| contig00561 | 292 | 1161 | ROBA | 0/0 | 100.0 | 99.4 | MEG_6082 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_RND_efflux_pumps:ROBA | NA |
| contig00610 | 1843 | 2166 | SOXS | 0/0 | 100.0 | 100.0 | MEG_6551 | Multi-compound:Drug_and_biocide_and_metal_resistance:Drug_and_biocide_and_metal_resistance_regulator:SOXS | NA |
| contig00016 | 1123 | 1914 | SULIII | 0/0 | 100.0 | 99.9 | MEG_6639 | Drugs:Sulfonamides:Sulfonamide-resistant_dihydropteroate_synthases:SULIII | NA |
| contig00088 | 3575 | 4820 | TEM | 0/0 | 98.3 | 99.4 | MEG_6875 | Drugs:betalactams:Class_A_betalactamases:TEM | NA |
| contig00228 | 1448 | 2722 | TETA | 0/0 | 100.0 | 99.9 | MEG_7024 | Drugs:Tetracyclines:Tetracycline_resistance_MFS_efflux_pumps:TETA | NA |
Presence/Absence of antibiotic resistance genes (coverage and identity > 90%) on each sample
## [1] "NO PLASMID FOUND!!"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00031 | 5673 | 5814 | IncI1_1_Alpha | 0/0 | 100 | 99.3 | AP005147 | IncI1_1_Alpha_AP005147 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00150 | 3342 | 3729 | IncFIA_1 | 0/0 | 100 | 100.0 | AP001918 | IncFIA_1__AP001918 |
| contig00087 | 1891 | 2572 | IncFIB(AP001918)_1 | 0/0 | 100 | 98.4 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| contig00028 | 3737 | 3878 | IncI1_1_Alpha | 0/0 | 100 | 100.0 | AP005147 | IncI1_1_Alpha_AP005147 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00874 | 452 | 712 | IncFII(pRSB107)_1_pRSB107 | 0/0 | 100 | 100 | AJ851089 | IncFII(pRSB107)_1_pRSB107_AJ851089 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00024 | 593 | 1274 | IncFIB(AP001918)_1 | 0/0 | 100 | 97.7 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig01949 | 1 | 485 | IncHI1B(CIT)_1_pNDM-CIT | 0/0 | 90.2 | 92.8 | JX182975 | IncHI1B(CIT)_1_pNDM-CIT_JX182975 |
| contig00432 | 1416 | 2300 | p0111_1 | 0/0 | 100.0 | 98.5 | AP010962 | p0111_1__AP010962 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig02025 | 68 | 328 | IncFII_1 | 0/0 | 100 | 97.7 | AY458016 | IncFII_1__AY458016 |
## [1] "NO PLASMID FOUND!!"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig01904 | 68 | 328 | IncFII_1 | 0/0 | 100 | 97.7 | AY458016 | IncFII_1__AY458016 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00411 | 2272 | 2953 | IncFIB(AP001918)_1 | 0/0 | 100 | 98.2 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00152 | 41 | 428 | IncFIA_1 | 0/0 | 100 | 100.0 | AP001918 | IncFIA_1__AP001918 |
| contig00005 | 4677 | 5358 | IncFIB(AP001918)_1 | 0/0 | 100 | 98.5 | AP001918 | IncFIB(AP001918)_1__AP001918 |
## [1] "NO PLASMID FOUND!!"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00037 | 5978 | 6659 | IncFIB(AP001918)_1 | 0/0 | 100 | 97.4 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| contig00027 | 8857 | 9117 | IncFII(pRSB107)_1_pRSB107 | 0/0 | 100 | 100.0 | AJ851089 | IncFII(pRSB107)_1_pRSB107_AJ851089 |
## [1] "NO PLASMID FOUND!!"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00049 | 1589 | 2270 | IncFIB(AP001918)_1 | 0/0 | 100 | 98.4 | AP001918 | IncFIB(AP001918)_1__AP001918 |
## [1] "NO PLASMID FOUND!!"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00229 | 3240 | 3986 | IncFII(pECLA)_1_pECLA | 0/0 | 100 | 96.2 | CP001919 | IncFII(pECLA)_1_pECLA_CP001919 |
## [1] "NO PLASMID FOUND!!"
## [1] "NO PLASMID FOUND!!"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00001 | 10913 | 11594 | IncFIB(AP001918)_1 | 0/0 | 100 | 99.6 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00153 | 1170 | 1851 | IncFIB(AP001918)_1 | 0/0 | 100 | 98.7 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| contig00086 | 2974 | 3234 | IncFII(pRSB107)_1_pRSB107 | 0/0 | 100 | 100.0 | AJ851089 | IncFII(pRSB107)_1_pRSB107_AJ851089 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00009 | 685 | 838 | Col156_1 | 0/0 | 100 | 98.7 | NC_009781 | Col156_1__NC_009781 |
| contig00049 | 2274 | 2955 | IncFIB(AP001918)_1 | 0/0 | 100 | 96.6 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| contig00197 | 1122 | 1380 | IncFII(29)_1_pUTI89 | 0/0 | 100 | 100.0 | CP003035 | IncFII(29)_1_pUTI89_CP003035 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00322 | 1833 | 2514 | IncFIB(AP001918)_1 | 0/0 | 100 | 98.4 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00093 | 4747 | 4897 | IncB/O/K/Z_1 | 2/2 | 99.3 | 98.0 | CU928147 | IncB/O/K/Z_1__CU928147 |
| contig00343 | 779 | 1460 | IncFIB(AP001918)_1 | 0/0 | 100.0 | 97.2 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00175 | 1709 | 1818 | Col440I_1 | 0/0 | 96.5 | 96.4 | CP023920.1 | Col440I_1__CP023920.1 |
| contig01726 | 486 | 848 | IncFIA_1 | 0/0 | 93.6 | 99.2 | AP001918 | IncFIA_1__AP001918 |
| contig00340 | 763 | 1444 | IncFIB(AP001918)_1 | 0/0 | 100.0 | 97.5 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00019 | 3211 | 3362 | Col156_1 | 0/0 | 98.7 | 95.4 | NC_009781 | Col156_1__NC_009781 |
## [1] "NO PLASMID FOUND!!"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00879 | 526 | 945 | IncHI1A_1 | 0/0 | 100 | 100 | AF250878 | IncHI1A_1__AF250878 |
| contig00001 | 19858 | 20852 | pSL483_1 | 0/0 | 100 | 93 | CP001137 | pSL483_1__CP001137 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00554 | 288 | 549 | Col(MG828)_1 | 0/0 | 100 | 92.0 | NC_008486 | Col(MG828)_1__NC_008486 |
| contig00718 | 484 | 1165 | IncFIB(AP001918)_1 | 0/0 | 100 | 95.3 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00111 | 1273 | 1414 | Col156_1 | 0/0 | 92.2 | 98.6 | NC_009781 | Col156_1__NC_009781 |
| contig00049 | 1679 | 2360 | IncFIB(AP001918)_1 | 0/0 | 100.0 | 96.6 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| contig00016 | 3322 | 3580 | IncFII(29)_1_pUTI89 | 0/0 | 100.0 | 99.6 | CP003035 | IncFII(29)_1_pUTI89_CP003035 |
| contig00006 | 7317 | 8081 | IncY_1 | 0/0 | 100.0 | 99.9 | K02380 | IncY_1__K02380 |
## [1] "NO PLASMID FOUND!!"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00001 | 3365 | 3748 | IncFIA_1 | 0/0 | 99.0 | 100.0 | AP001918 | IncFIA_1__AP001918 |
| contig00027 | 564 | 1245 | IncFIB(AP001918)_1 | 0/0 | 100.0 | 97.8 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| contig00011 | 1600 | 2096 | IncFIC(FII)_1 | 1/2 | 99.6 | 95.6 | AP001918 | IncFIC(FII)_1__AP001918 |
## [1] "NO PLASMID FOUND!!"
## [1] "NO PLASMID FOUND!!"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00003 | 12699 | 13380 | IncFIB(AP001918)_1 | 0/0 | 100 | 99.3 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00024 | 10697 | 11461 | IncY_1 | 0/0 | 100 | 98.8 | K02380 | IncY_1__K02380 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig01233 | 359 | 512 | Col156_1 | 0/0 | 100 | 98.7 | NC_009781 | Col156_1__NC_009781 |
| contig00087 | 2156 | 2837 | IncFIB(AP001918)_1 | 0/0 | 100 | 96.6 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| contig00001 | 10360 | 10618 | IncFII(29)_1_pUTI89 | 0/0 | 100 | 100.0 | CP003035 | IncFII(29)_1_pUTI89_CP003035 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00011 | 4050 | 4163 | Col440I_1 | 0/0 | 100.0 | 94.7 | CP023920.1 | Col440I_1__CP023920.1 |
| contig00512 | 1576 | 1730 | IncB/O/K/Z_2 | 1/1 | 96.2 | 96.1 | GU256641 | IncB/O/K/Z_2__GU256641 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00249 | 1371 | 1484 | Col440I_1 | 0/0 | 100 | 94.7 | CP023920.1 | Col440I_1__CP023920.1 |
| contig00048 | 2262 | 2943 | IncFIB(AP001918)_1 | 0/0 | 100 | 96.8 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00035 | 1832 | 2513 | IncFIB(AP001918)_1 | 0/0 | 100 | 98.4 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00011 | 3365 | 3752 | IncFIA_1 | 0/0 | 100 | 99.7 | AP001918 | IncFIA_1__AP001918 |
| contig00032 | 1858 | 2539 | IncFIB(AP001918)_1 | 0/0 | 100 | 97.7 | AP001918 | IncFIB(AP001918)_1__AP001918 |
| contig00020 | 4419 | 4679 | IncFII(pRSB107)_1_pRSB107 | 0/0 | 100 | 100.0 | AJ851089 | IncFII(pRSB107)_1_pRSB107_AJ851089 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00066 | 4509 | 4759 | IncR_1 | 0/0 | 100 | 100 | DQ449578 | IncR_1__DQ449578 |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00811 | 567 | 1424 | entB | 0/0 | 100.0 | 97.4 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01448 | 1 | 915 | fepB | 0/0 | 95.6 | 97.5 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00635 | 750 | 1940 | fes | 0/0 | 99.0 | 96.7 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00029 | 5052 | 5656 | fimA | 1/1 | 99.8 | 90.8 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00029 | 3686 | 4411 | fimC | 0/0 | 100.0 | 98.9 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00029 | 983 | 3619 | fimD | 0/0 | 100.0 | 98.5 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00029 | 443 | 976 | fimF | 0/0 | 100.0 | 96.6 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01450 | 70 | 978 | fimH | 0/0 | 99.7 | 97.6 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00029 | 4448 | 4987 | fimI | 0/0 | 100.0 | 98.5 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00321 | 1535 | 2365 | gspC | 0/0 | 100.0 | 95.0 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00572 | 210 | 740 | gspH | 0/0 | 100.0 | 95.7 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00572 | 737 | 1108 | gspI | 0/0 | 100.0 | 95.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00572 | 1141 | 1710 | gspJ | 0/0 | 100.0 | 96.5 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00019 | 167 | 1027 | gspL | 0/0 | 100.0 | 97.6 | YP_404608 | (gspL) general secretion pathway protein L [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00019 | 1143 | 1565 | gspM | 0/0 | 100.0 | 94.1 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01138 | 182 | 1234 | ompA | 1/12 | 100.0 | 94.3 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00733 | 555 | 1308 | yagV/ecpE | 0/0 | 99.7 | 96.7 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00208 | 2441 | 3109 | yagY/ecpB | 0/0 | 100.0 | 98.7 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00208 | 1796 | 2383 | yagZ/ecpA | 0/0 | 100.0 | 99.3 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00208 | 1131 | 1721 | ykgK/ecpR | 0/0 | 100.0 | 97.6 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00272 | 680 | 1708 | chuS | 0/0 | 100.0 | 97.0 | NP_756169 | (chuS) heme oxygenase ChuS [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00409 | 326 | 1318 | chuU | 0/0 | 100.0 | 99.0 | NP_756179 | (chuU) heme permease protein ChuU [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00409 | 1285 | 2085 | chuV | 0/0 | 100.0 | 98.1 | NP_756180 | (chuV) ATP-binding hydrophilic protein ChuV [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00425 | 468 | 1805 | chuW | 0/0 | 100.0 | 96.7 | NP_756176 | (chuW) Putative oxygen independent coproporphyrinogen III oxidase [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00273 | 1204 | 1950 | entA | 0/0 | 100.0 | 96.0 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00273 | 347 | 1204 | entB | 0/0 | 100.0 | 98.5 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00344 | 1 | 2014 | espL4 | 0/0 | 92.1 | 97.3 | NP_290644 | (espL4) Type III secretion system effector EspL4 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig00066 | 122 | 4372 | fdeC | 0/0 | 100.0 | 94.8 | YP_002390132 | (fdeC) adhesin FdeC [FdeC (VF0506)] [Escherichia coli O45:K1:H7 str. S88] |
| contig00395 | 9 | 1025 | fepD | 0/0 | 100.0 | 95.6 | NP_752608 | (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00395 | 1022 | 2014 | fepG | 0/0 | 100.0 | 95.5 | NP_752607 | (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00789 | 600 | 1802 | fes | 0/0 | 100.0 | 96.6 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig01269 | 490 | 1095 | fimA | 0/0 | 100.0 | 90.4 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01910 | 3 | 605 | fimB | 0/0 | 100.0 | 97.8 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00224 | 2609 | 3334 | fimC | 0/0 | 100.0 | 98.6 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00224 | 1 | 2543 | fimD | 0/0 | 96.4 | 98.3 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01895 | 299 | 757 | fimG | 0/0 | 91.1 | 97.8 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01560 | 70 | 981 | fimH | 0/0 | 100.0 | 97.3 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00487 | 700 | 1530 | gspC | 0/0 | 100.0 | 94.6 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00280 | 1133 | 2626 | gspE | 0/0 | 100.0 | 94.3 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00441 | 457 | 912 | gspG | 0/0 | 100.0 | 96.7 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00441 | 949 | 1479 | gspH | 0/0 | 100.0 | 96.4 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00441 | 1476 | 1847 | gspI | 0/0 | 100.0 | 93.5 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00441 | 1880 | 2449 | gspJ | 0/0 | 100.0 | 96.0 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00650 | 850 | 1272 | gspM | 0/0 | 100.0 | 97.4 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00949 | 215 | 1255 | ompA | 0/0 | 100.0 | 98.8 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00425 | 1818 | 2312 | shuX | 0/0 | 100.0 | 95.8 | YP_405016 | (shuX) shu locus protein ShuX [Shu (VF0256)] [Shigella dysenteriae Sd197] |
| contig00639 | 1364 | 2032 | yagY/ecpB | 0/0 | 100.0 | 98.4 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00639 | 719 | 1306 | yagZ/ecpA | 0/0 | 100.0 | 99.0 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00639 | 54 | 644 | ykgK/ecpR | 0/0 | 100.0 | 99.0 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig01089 | 316 | 1173 | entB | 0/0 | 100.0 | 97.8 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00015 | 5480 | 7818 | faeD | 0/0 | 95.9 | 91.4 | YP_002295985 | (faeD) fimbrial usher protein FaeD [K88 pili/F4 fimbriae (AI040)] [Escherichia coli SE11] |
| contig00485 | 47 | 862 | fepC | 0/0 | 100.0 | 97.2 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00429 | 326 | 1528 | fes | 0/0 | 100.0 | 96.4 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00696 | 1406 | 2011 | fimA | 0/0 | 100.0 | 90.9 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00696 | 40 | 765 | fimC | 0/0 | 100.0 | 98.1 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00139 | 2018 | 4588 | fimD | 0/0 | 97.5 | 98.8 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01967 | 1 | 590 | fimE | 0/0 | 98.8 | 98.6 | NP_757240 | (fimE) Type 1 fimbriae Regulatory protein fimE [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00139 | 1478 | 2011 | fimF | 0/0 | 100.0 | 96.6 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00139 | 962 | 1465 | fimG | 0/0 | 100.0 | 97.8 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00139 | 40 | 951 | fimH | 0/0 | 100.0 | 97.5 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00696 | 802 | 1341 | fimI | 0/0 | 100.0 | 98.7 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00417 | 1 | 1792 | gspD | 1/15 | 96.8 | 96.9 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00149 | 2965 | 3420 | gspG | 0/0 | 100.0 | 95.6 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00149 | 2398 | 2928 | gspH | 0/0 | 100.0 | 95.3 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00149 | 2030 | 2401 | gspI | 0/0 | 100.0 | 95.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00149 | 1428 | 1997 | gspJ | 0/0 | 100.0 | 97.4 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00149 | 454 | 1431 | gspK | 0/0 | 100.0 | 96.6 | YP_404607 | (gspK) general secretion pathway protein K [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig02005 | 103 | 525 | gspM | 0/0 | 100.0 | 93.8 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00945 | 303 | 1343 | ompA | 0/0 | 100.0 | 98.2 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00749 | 1024 | 1777 | yagV/ecpE | 0/0 | 99.7 | 96.8 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00045 | 5576 | 6244 | yagY/ecpB | 0/0 | 100.0 | 98.1 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00045 | 4931 | 5518 | yagZ/ecpA | 0/0 | 100.0 | 99.3 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00045 | 4266 | 4856 | ykgK/ecpR | 0/0 | 100.0 | 97.8 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00004 | 1062 | 1178 | astA | 0/0 | 100.0 | 98.3 | BAA94855 | (astA) heat-stable enterotoxin 1 [EAST1 (VF0216)] [Escherichia coli O44:H18 042] |
| contig01377 | 150 | 719 | espY2 | 0/0 | 100.0 | 94.4 | NP_285765 | (espY2) Type III secretion system effector EspY2 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig01066 | 109 | 703 | fimE | 0/0 | 99.7 | 99.2 | NP_757240 | (fimE) Type 1 fimbriae Regulatory protein fimE [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00119 | 309 | 812 | fimG | 0/0 | 100.0 | 98.0 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00119 | 823 | 1734 | fimH | 0/0 | 100.0 | 97.7 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00435 | 499 | 1038 | fimI | 0/0 | 100.0 | 98.3 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00083 | 894 | 1724 | gspC | 0/0 | 100.0 | 94.6 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00446 | 381 | 752 | gspI | 0/0 | 100.0 | 96.0 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00187 | 525 | 887 | gtrA | 0/0 | 100.0 | 90.1 | NP_706257 | (gtrA) bactoprenol-linked glucose translocase/flippase [LPS (VF0124)] [Shigella flexneri 2a str. 301] |
| contig00623 | 1 | 775 | kpsM | 0/0 | 99.7 | 94.1 | AAA24046 | (kpsM) KpsM [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig01126 | 110 | 697 | yagZ/ecpA | 0/0 | 100.0 | 98.8 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig01774 | 170 | 286 | astA | 0/0 | 100 | 96.6 | BAA94855 | (astA) heat-stable enterotoxin 1 [EAST1 (VF0216)] [Escherichia coli O44:H18 042] |
| contig01134 | 139 | 996 | entB | 0/0 | 100 | 97.4 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01018 | 500 | 1102 | fimB | 0/0 | 100 | 98.0 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00043 | 1488 | 2021 | fimF | 0/0 | 100 | 97.8 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00043 | 972 | 1475 | fimG | 0/0 | 100 | 98.2 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00043 | 50 | 961 | fimH | 0/0 | 100 | 97.8 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00532 | 638 | 1177 | fimI | 0/0 | 100 | 97.8 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00002 | 2300 | 5296 | hlyA | 0/0 | 100 | 98.4 | YP_325608 | (hlyA) hemolysin toxin protein [Hemolysin (VF0207)] [Escherichia coli O157:H7 str. EDL933] |
| contig00002 | 130 | 2250 | hlyB | 0/0 | 100 | 99.2 | YP_325609 | (hlyB) hemolysin transport protein [Hemolysin (VF0207)] [Escherichia coli O157:H7 str. EDL933] |
| contig00002 | 5298 | 5813 | hlyC | 0/0 | 100 | 97.1 | YP_325607 | (hlyC) hemolysin transport protein [Hemolysin (VF0207)] [Escherichia coli O157:H7 str. EDL933] |
| contig00038 | 1657 | 2697 | ompA | 0/0 | 100 | 98.1 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00548 | 378 | 1337 | stx2A | 0/0 | 100 | 98.3 | NP_286976 | (stx2A) shiga-like toxin II A subunit encoded by bacteriophage BP-933W [Stx (VF0206)] [Escherichia coli O157:H7 str. EDL933] |
| contig00548 | 97 | 366 | stx2B | 0/0 | 100 | 96.7 | NP_286977 | (stx2B) shiga-like toxin II B subunit encoded by bacteriophage BP-933W [Stx (VF0206)] [Escherichia coli O157:H7 str. EDL933] |
| contig00188 | 1629 | 2297 | yagY/ecpB | 0/0 | 100 | 98.4 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00188 | 983 | 1570 | yagZ/ecpA | 0/0 | 100 | 99.2 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00188 | 318 | 908 | ykgK/ecpR | 0/0 | 100 | 97.3 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00834 | 45 | 1473 | aslA | 1/1 | 100.0 | 92.9 | AAG10151 | (aslA) putative arylsulfatase [AslA (VF0238)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00351 | 436 | 1182 | entA | 0/0 | 100.0 | 95.7 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00616 | 253 | 1440 | entC | 0/0 | 100.0 | 97.9 | NP_752611 | (entC) isochorismate synthase 1 [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00568 | 1033 | 1848 | fepC | 0/0 | 100.0 | 97.3 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00544 | 692 | 1708 | fepD | 0/0 | 100.0 | 96.1 | NP_752608 | (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01481 | 206 | 811 | fimA | 0/0 | 100.0 | 90.4 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01878 | 1 | 592 | fimB | 0/0 | 98.2 | 97.8 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00060 | 4751 | 5476 | fimC | 0/0 | 100.0 | 98.3 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00060 | 2048 | 4684 | fimD | 0/0 | 100.0 | 98.3 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00060 | 1508 | 2041 | fimF | 0/0 | 100.0 | 97.4 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00060 | 992 | 1495 | fimG | 0/0 | 100.0 | 98.4 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00060 | 70 | 981 | fimH | 0/0 | 100.0 | 97.4 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00058 | 500 | 1330 | gspC | 0/0 | 100.0 | 95.4 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00058 | 1570 | 3420 | gspD | 1/15 | 100.0 | 97.1 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00058 | 3420 | 4913 | gspE | 0/0 | 100.0 | 96.5 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01861 | 200 | 636 | gspG | 0/0 | 95.8 | 94.7 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01714 | 187 | 558 | gspI | 0/0 | 100.0 | 95.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00724 | 23 | 883 | gspL | 0/0 | 100.0 | 97.2 | YP_404608 | (gspL) general secretion pathway protein L [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig02101 | 103 | 490 | gspM | 0/0 | 91.7 | 97.9 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00787 | 413 | 1453 | ompA | 0/0 | 100.0 | 98.1 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig01075 | 459 | 1205 | entA | 0/0 | 100.0 | 96.0 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01095 | 1 | 1143 | entC | 0/0 | 96.2 | 97.4 | NP_752611 | (entC) isochorismate synthase 1 [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01474 | 1 | 928 | fepB | 0/0 | 97.0 | 97.5 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00434 | 1213 | 2028 | fepC | 0/0 | 100.0 | 97.3 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01489 | 386 | 976 | fimA | 1/1 | 97.5 | 90.4 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00566 | 406 | 909 | fimG | 0/0 | 100.0 | 98.2 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00566 | 920 | 1831 | fimH | 0/0 | 100.0 | 97.7 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00963 | 326 | 1156 | gspC | 0/0 | 100.0 | 95.1 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00088 | 330 | 1823 | gspE | 0/0 | 100.0 | 97.1 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00088 | 1823 | 3022 | gspF | 0/0 | 100.0 | 96.2 | YP_404602 | (gspF) general secretion pathway protein F [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00088 | 3063 | 3518 | gspG | 0/0 | 100.0 | 95.6 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01337 | 118 | 687 | gspJ | 0/0 | 100.0 | 97.2 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig02122 | 93 | 515 | gspM | 0/0 | 100.0 | 94.1 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01152 | 154 | 1206 | ompA | 1/12 | 100.0 | 94.3 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00142 | 779 | 1447 | yagY/ecpB | 0/0 | 100.0 | 98.7 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00142 | 134 | 721 | yagZ/ecpA | 0/0 | 100.0 | 99.3 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig01620 | 142 | 823 | entA | 0/0 | 91.3 | 95.5 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01918 | 74 | 679 | fimA | 0/0 | 100.0 | 90.9 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01743 | 194 | 780 | fimB | 0/0 | 97.3 | 97.8 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00462 | 786 | 1511 | fimC | 0/0 | 100.0 | 98.2 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00488 | 943 | 1476 | fimF | 0/0 | 100.0 | 96.6 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00488 | 427 | 930 | fimG | 0/0 | 100.0 | 97.8 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00139 | 1787 | 2356 | gspJ | 0/0 | 100.0 | 97.2 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00139 | 813 | 1790 | gspK | 0/0 | 100.0 | 97.5 | YP_404607 | (gspK) general secretion pathway protein K [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00063 | 1366 | 2034 | yagY/ecpB | 0/0 | 100.0 | 98.5 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00063 | 721 | 1308 | yagZ/ecpA | 0/0 | 100.0 | 99.3 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00063 | 56 | 646 | ykgK/ecpR | 0/0 | 100.0 | 97.6 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00668 | 795 | 1541 | entA | 0/0 | 100.0 | 96.0 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00668 | 1 | 795 | entB | 0/0 | 92.7 | 97.6 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00539 | 1025 | 2275 | entS | 0/0 | 100.0 | 95.8 | NP_752609 | (entS) enterobactin exporter iron-regulated [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00539 | 65 | 1021 | fepB | 0/0 | 100.0 | 97.4 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00494 | 725 | 1927 | fes | 0/0 | 100.0 | 96.8 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig02179 | 1 | 550 | fimA | 1/1 | 90.8 | 90.2 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01682 | 242 | 844 | fimB | 0/0 | 100.0 | 98.0 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01023 | 223 | 948 | fimC | 0/0 | 100.0 | 98.3 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00415 | 319 | 852 | fimF | 0/0 | 100.0 | 97.8 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01403 | 50 | 961 | fimH | 0/0 | 100.0 | 97.7 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01023 | 985 | 1524 | fimI | 0/0 | 100.0 | 99.1 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00212 | 775 | 1605 | gspC | 0/0 | 100.0 | 95.1 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00212 | 1845 | 3648 | gspD | 1/15 | 97.4 | 97.1 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00173 | 1 | 1448 | gspE | 0/0 | 96.9 | 97.0 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00173 | 1448 | 2647 | gspF | 0/0 | 100.0 | 96.2 | YP_404602 | (gspF) general secretion pathway protein F [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00173 | 2688 | 3143 | gspG | 0/0 | 100.0 | 95.6 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00173 | 3180 | 3710 | gspH | 0/0 | 100.0 | 96.0 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01267 | 301 | 1054 | yagV/ecpE | 0/0 | 99.7 | 96.8 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00396 | 1 | 2330 | yagX/ecpC | 0/0 | 92.2 | 98.5 | NP_286008 | (yagX/ecpC) E. coli common pilus usher EcpC [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig01851 | 51 | 641 | ykgK/ecpR | 0/0 | 100.0 | 97.6 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00761 | 247 | 1675 | aslA | 1/1 | 100.0 | 92.7 | AAG10151 | (aslA) putative arylsulfatase [AslA (VF0238)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00297 | 3931 | 4677 | entA | 0/0 | 100.0 | 95.7 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00297 | 3074 | 3931 | entB | 0/0 | 100.0 | 98.1 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00297 | 253 | 1440 | entC | 0/0 | 100.0 | 97.8 | NP_752611 | (entC) isochorismate synthase 1 [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00297 | 1450 | 3060 | entE | 0/0 | 100.0 | 95.4 | NP_752612 | (entE) 23-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00720 | 39 | 1289 | entS | 0/0 | 100.0 | 95.4 | NP_752609 | (entS) enterobactin exporter iron-regulated [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00634 | 169 | 2409 | fepA | 0/0 | 100.0 | 96.7 | NP_752600 | (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00437 | 1571 | 2386 | fepC | 0/0 | 100.0 | 97.2 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00437 | 2383 | 3375 | fepG | 0/0 | 100.0 | 94.1 | NP_752607 | (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00513 | 23 | 1225 | fes | 0/0 | 100.0 | 96.7 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig01083 | 234 | 836 | fimB | 0/0 | 100.0 | 98.2 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00188 | 4090 | 4815 | fimC | 0/0 | 100.0 | 98.9 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00188 | 1387 | 4023 | fimD | 0/0 | 100.0 | 98.6 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01187 | 1 | 580 | fimE | 0/0 | 97.2 | 99.5 | NP_757240 | (fimE) Type 1 fimbriae Regulatory protein fimE [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00188 | 847 | 1380 | fimF | 0/0 | 100.0 | 97.9 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00188 | 331 | 834 | fimG | 0/0 | 100.0 | 97.8 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00188 | 4852 | 5391 | fimI | 0/0 | 100.0 | 98.5 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00306 | 653 | 2503 | gspD | 1/15 | 100.0 | 96.0 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00306 | 2503 | 3996 | gspE | 0/0 | 100.0 | 95.6 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00616 | 1876 | 2331 | gspG | 0/0 | 100.0 | 96.0 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00616 | 1309 | 1839 | gspH | 0/0 | 100.0 | 96.2 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00616 | 941 | 1312 | gspI | 0/0 | 100.0 | 94.6 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00616 | 339 | 908 | gspJ | 0/0 | 100.0 | 94.7 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00752 | 193 | 1053 | gspL | 0/0 | 100.0 | 95.2 | YP_404608 | (gspL) general secretion pathway protein L [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00799 | 725 | 1501 | kpsM | 0/0 | 100.0 | 95.0 | AAA24046 | (kpsM) KpsM [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00530 | 1006 | 2046 | ompA | 0/0 | 100.0 | 98.1 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00280 | 837 | 1590 | yagV/ecpE | 0/0 | 99.7 | 97.0 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00255 | 2055 | 4580 | yagX/ecpC | 0/0 | 100.0 | 98.7 | NP_286008 | (yagX/ecpC) E. coli common pilus usher EcpC [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00255 | 1361 | 2029 | yagY/ecpB | 0/0 | 100.0 | 99.0 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00255 | 716 | 1303 | yagZ/ecpA | 0/0 | 100.0 | 99.3 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00255 | 51 | 641 | ykgK/ecpR | 0/0 | 100.0 | 97.3 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00228 | 125 | 2365 | fepA | 0/0 | 100.0 | 97.6 | NP_752600 | (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00886 | 27 | 530 | fimG | 0/0 | 100.0 | 97.8 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01120 | 156 | 986 | gspC | 0/0 | 100.0 | 95.1 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00175 | 38 | 1888 | gspD | 1/15 | 100.0 | 97.6 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00117 | 665 | 1864 | gspF | 0/0 | 100.0 | 96.2 | YP_404602 | (gspF) general secretion pathway protein F [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00117 | 1905 | 2360 | gspG | 0/0 | 100.0 | 95.6 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00117 | 2397 | 2927 | gspH | 0/0 | 100.0 | 96.0 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00200 | 1722 | 2291 | gspJ | 0/0 | 100.0 | 97.2 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00200 | 748 | 1725 | gspK | 0/0 | 100.0 | 97.5 | YP_404607 | (gspK) general secretion pathway protein K [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00190 | 1577 | 2330 | yagV/ecpE | 0/0 | 99.7 | 96.8 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00190 | 10 | 1653 | yagW/ecpD | 0/0 | 100.0 | 98.7 | NP_286007 | (yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00726 | 688 | 1356 | yagY/ecpB | 0/0 | 100.0 | 98.2 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00726 | 43 | 630 | yagZ/ecpA | 0/0 | 100.0 | 99.3 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00139 | 286 | 819 | fimF | 0/0 | 100 | 96.6 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00401 | 21 | 392 | gspI | 0/0 | 100 | 95.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00577 | 1 | 2446 | aggC | 0/0 | 96.7 | 99.7 | AAA57452 | (aggC) usher protein [AAFs (VF0214)] [Escherichia coli 17-2] |
| contig00825 | 1118 | 1234 | astA | 0/0 | 100.0 | 98.3 | BAA94855 | (astA) heat-stable enterotoxin 1 [EAST1 (VF0216)] [Escherichia coli O44:H18 042] |
| contig00141 | 1640 | 2632 | chuU | 0/0 | 100.0 | 98.6 | NP_756179 | (chuU) heme permease protein ChuU [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00141 | 873 | 1673 | chuV | 0/0 | 100.0 | 98.9 | NP_756180 | (chuV) ATP-binding hydrophilic protein ChuV [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00141 | 3811 | 5148 | chuW | 0/0 | 100.0 | 96.7 | NP_756176 | (chuW) Putative oxygen independent coproporphyrinogen III oxidase [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00141 | 2681 | 3304 | chuY | 0/0 | 100.0 | 97.0 | NP_756178 | (chuY) ChuY [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00579 | 1393 | 2250 | entB | 0/0 | 100.0 | 97.8 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00664 | 516 | 2414 | espL1 | 0/0 | 100.0 | 96.7 | NP_288154 | (espL1) Type III secretion system effector espL1 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig00424 | 98 | 667 | espY2 | 0/0 | 100.0 | 94.4 | NP_285765 | (espY2) Type III secretion system effector EspY2 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig01061 | 654 | 1431 | fepC | 0/0 | 95.3 | 97.3 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00718 | 837 | 1853 | fepD | 0/0 | 100.0 | 96.1 | NP_752608 | (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00666 | 479 | 1681 | fes | 0/0 | 100.0 | 96.8 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00669 | 1727 | 2332 | fimA | 0/0 | 100.0 | 92.2 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01052 | 790 | 1391 | fimB | 1/1 | 99.8 | 98.0 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00669 | 361 | 1086 | fimC | 0/0 | 100.0 | 98.6 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01311 | 171 | 765 | fimE | 0/0 | 99.7 | 99.2 | NP_757240 | (fimE) Type 1 fimbriae Regulatory protein fimE [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01014 | 32 | 535 | fimG | 0/0 | 100.0 | 98.0 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01014 | 546 | 1457 | fimH | 0/0 | 100.0 | 97.7 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00669 | 1123 | 1662 | fimI | 0/0 | 100.0 | 98.3 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00107 | 1511 | 2341 | gspC | 0/0 | 100.0 | 94.6 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00107 | 2581 | 4431 | gspD | 1/15 | 100.0 | 95.4 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00107 | 4431 | 5924 | gspE | 0/0 | 100.0 | 95.0 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00399 | 115 | 570 | gspG | 0/0 | 100.0 | 97.8 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00399 | 607 | 1137 | gspH | 0/0 | 100.0 | 95.9 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00399 | 1134 | 1505 | gspI | 0/0 | 100.0 | 96.0 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00399 | 1538 | 2107 | gspJ | 0/0 | 100.0 | 95.3 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00399 | 2104 | 3081 | gspK | 0/0 | 100.0 | 97.0 | YP_404607 | (gspK) general secretion pathway protein K [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01345 | 444 | 853 | gspM | 0/0 | 96.9 | 97.6 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01015 | 511 | 873 | gtrA | 0/0 | 100.0 | 90.1 | NP_706257 | (gtrA) bactoprenol-linked glucose translocase/flippase [LPS (VF0124)] [Shigella flexneri 2a str. 301] |
| contig00541 | 1 | 1586 | kpsD | 0/0 | 94.6 | 96.9 | AAA21682 | (kpsD) KpsD [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00917 | 626 | 1402 | kpsM | 0/0 | 100.0 | 94.1 | AAA24046 | (kpsM) KpsM [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00071 | 1015 | 2055 | ompA | 0/0 | 100.0 | 98.9 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00327 | 1160 | 2188 | shuS | 0/0 | 100.0 | 96.5 | YP_405020 | (shuS) heme/hemoglobin transport protein ShuS [Shu (VF0256)] [Shigella dysenteriae Sd197] |
| contig00141 | 3304 | 3798 | shuX | 0/0 | 100.0 | 96.4 | YP_405016 | (shuX) shu locus protein ShuX [Shu (VF0256)] [Shigella dysenteriae Sd197] |
| contig00215 | 856 | 1609 | yagV/ecpE | 0/0 | 99.7 | 97.0 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00468 | 1031 | 1699 | yagY/ecpB | 0/0 | 100.0 | 98.4 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00468 | 386 | 973 | yagZ/ecpA | 0/0 | 100.0 | 98.8 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00347 | 1563 | 2813 | entS | 0/0 | 100.0 | 95.6 | NP_752609 | (entS) enterobactin exporter iron-regulated [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00083 | 2562 | 4460 | espL1 | 0/0 | 100.0 | 94.9 | NP_288154 | (espL1) Type III secretion system effector espL1 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig00153 | 278 | 4503 | fdeC | 1/3 | 99.4 | 91.0 | YP_002390132 | (fdeC) adhesin FdeC [FdeC (VF0506)] [Escherichia coli O45:K1:H7 str. S88] |
| contig00347 | 603 | 1559 | fepB | 0/0 | 100.0 | 97.4 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00745 | 794 | 1609 | fepC | 0/0 | 100.0 | 97.1 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01602 | 208 | 810 | fimB | 0/0 | 100.0 | 98.0 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00552 | 343 | 1068 | fimC | 0/0 | 100.0 | 98.6 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00175 | 1488 | 2021 | fimF | 0/0 | 100.0 | 97.8 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00175 | 972 | 1475 | fimG | 0/0 | 100.0 | 98.4 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00175 | 50 | 961 | fimH | 0/0 | 100.0 | 97.7 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00552 | 1105 | 1644 | fimI | 0/0 | 100.0 | 97.6 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00433 | 1535 | 2365 | gspC | 0/0 | 100.0 | 95.0 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00567 | 200 | 655 | gspG | 0/0 | 100.0 | 95.6 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00567 | 692 | 1222 | gspH | 0/0 | 100.0 | 96.0 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00567 | 1219 | 1590 | gspI | 0/0 | 100.0 | 95.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00567 | 1623 | 2192 | gspJ | 0/0 | 100.0 | 97.4 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01929 | 103 | 525 | gspM | 0/0 | 100.0 | 93.8 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00382 | 56 | 1096 | ompA | 0/0 | 100.0 | 98.1 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00108 | 1461 | 2214 | yagV/ecpE | 0/0 | 99.7 | 96.8 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00108 | 1 | 1537 | yagW/ecpD | 0/0 | 93.5 | 98.8 | NP_286007 | (yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00080 | 3997 | 4665 | yagY/ecpB | 0/0 | 100.0 | 98.7 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00080 | 3352 | 3939 | yagZ/ecpA | 0/0 | 100.0 | 99.2 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00080 | 2687 | 3277 | ykgK/ecpR | 0/0 | 100.0 | 97.6 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00831 | 996 | 1598 | fimB | 0/0 | 100.0 | 97.7 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00203 | 1 | 2453 | fimD | 0/0 | 93.0 | 98.4 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01733 | 259 | 792 | fimF | 0/0 | 100.0 | 97.6 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01265 | 222 | 1133 | fimH | 0/0 | 100.0 | 97.3 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00888 | 68 | 607 | fimI | 0/0 | 100.0 | 98.7 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00695 | 92 | 922 | gspC | 0/0 | 100.0 | 96.6 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00115 | 1161 | 2360 | gspF | 0/0 | 100.0 | 96.0 | YP_404602 | (gspF) general secretion pathway protein F [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00115 | 2401 | 2856 | gspG | 0/0 | 100.0 | 95.0 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00115 | 2893 | 3423 | gspH | 0/0 | 100.0 | 95.5 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00115 | 3420 | 3788 | gspI | 0/0 | 99.2 | 95.1 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig02063 | 1 | 556 | gspJ | 0/0 | 97.5 | 96.8 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01302 | 640 | 1062 | gspM | 0/0 | 100.0 | 94.6 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01247 | 350 | 1103 | yagV/ecpE | 0/0 | 99.7 | 97.1 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00736 | 24 | 692 | yagY/ecpB | 0/0 | 100.0 | 99.0 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig01011 | 830 | 1398 | yagZ/ecpA | 0/0 | 96.8 | 99.3 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig01011 | 165 | 755 | ykgK/ecpR | 0/0 | 100.0 | 97.1 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00840 | 1047 | 1750 | entA | 0/0 | 94.2 | 96.3 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00507 | 588 | 2198 | entE | 0/0 | 100.0 | 95.9 | NP_752612 | (entE) 23-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00010 | 1 | 1214 | espX5 | 1/12 | 93.0 | 94.7 | NP_290699 | (espX5) Type III secretion system effector EspX5 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig00647 | 133 | 2373 | fepA | 0/0 | 100.0 | 96.8 | NP_752600 | (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00916 | 496 | 1452 | fepB | 0/0 | 100.0 | 97.3 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00401 | 759 | 1775 | fepD | 0/0 | 100.0 | 95.7 | NP_752608 | (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00401 | 1772 | 2764 | fepG | 0/0 | 100.0 | 94.6 | NP_752607 | (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00715 | 869 | 2071 | fes | 0/0 | 100.0 | 96.8 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig01265 | 221 | 823 | fimB | 0/0 | 100.0 | 97.8 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00444 | 786 | 1511 | fimC | 0/0 | 100.0 | 98.6 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00806 | 370 | 873 | fimG | 0/0 | 100.0 | 98.4 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00806 | 884 | 1795 | fimH | 0/0 | 100.0 | 97.6 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00444 | 1548 | 2087 | fimI | 0/0 | 100.0 | 97.8 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00021 | 9031 | 9861 | gspC | 0/0 | 100.0 | 95.1 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00021 | 6941 | 8791 | gspD | 1/15 | 100.0 | 97.3 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00021 | 5448 | 6941 | gspE | 0/0 | 100.0 | 96.2 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00021 | 4249 | 5448 | gspF | 0/0 | 100.0 | 96.3 | YP_404602 | (gspF) general secretion pathway protein F [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00021 | 3753 | 4208 | gspG | 0/0 | 100.0 | 95.6 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00021 | 3186 | 3716 | gspH | 0/0 | 100.0 | 95.9 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00021 | 2818 | 3189 | gspI | 0/0 | 100.0 | 95.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00021 | 2216 | 2785 | gspJ | 0/0 | 100.0 | 96.5 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00021 | 1242 | 2219 | gspK | 0/0 | 100.0 | 96.1 | YP_404607 | (gspK) general secretion pathway protein K [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00021 | 67 | 927 | gspL | 0/0 | 100.0 | 97.6 | YP_404608 | (gspL) general secretion pathway protein L [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01499 | 103 | 518 | gspM | 0/0 | 98.3 | 94.0 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00562 | 15 | 1067 | ompA | 1/12 | 100.0 | 94.3 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00206 | 950 | 1703 | yagV/ecpE | 0/0 | 99.7 | 96.7 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00029 | 7636 | 10161 | yagX/ecpC | 0/0 | 100.0 | 98.6 | NP_286008 | (yagX/ecpC) E. coli common pilus usher EcpC [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00029 | 6942 | 7610 | yagY/ecpB | 0/0 | 100.0 | 98.7 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00029 | 6297 | 6884 | yagZ/ecpA | 0/0 | 100.0 | 99.3 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00703 | 599 | 2176 | ybtE | 0/0 | 100.0 | 99.8 | NP_405468 | (ybtE) yersiniabactin siderophore biosynthetic protein [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00238 | 1606 | 2910 | ybtS | 0/0 | 100.0 | 97.5 | NP_405477 | (ybtS) salicylate synthase Irp9 [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00156 | 4921 | 6021 | ybtU | 0/0 | 100.0 | 99.6 | NP_405470 | (ybtU) yersiniabactin biosynthetic protein YbtU [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00238 | 2938 | 4218 | ybtX | 0/0 | 100.0 | 97.7 | NP_405476 | (ybtX) putative signal transducer [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00029 | 5632 | 6222 | ykgK/ecpR | 0/0 | 100.0 | 97.6 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
## [1] "NO VIRULENCE FACTORS DETECTED!!!"
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00512 | 53 | 1481 | aslA | 1/1 | 100.0 | 98.2 | AAG10151 | (aslA) putative arylsulfatase [AslA (VF0238)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00331 | 2261 | 4207 | chuA | 0/0 | 100.0 | 99.7 | NP_756170 | (chuA) Outer membrane heme/hemoglobin receptor ChuA [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00331 | 1184 | 2212 | chuS | 0/0 | 100.0 | 99.3 | NP_756169 | (chuS) heme oxygenase ChuS [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00414 | 107 | 1099 | chuT | 0/0 | 100.0 | 99.7 | NP_756175 | (chuT) periplasmic heme-binding protein ChuT [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00540 | 1614 | 2414 | chuV | 0/0 | 100.0 | 99.8 | NP_756180 | (chuV) ATP-binding hydrophilic protein ChuV [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00414 | 1119 | 2456 | chuW | 0/0 | 100.0 | 99.4 | NP_756176 | (chuW) Putative oxygen independent coproporphyrinogen III oxidase [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00414 | 2469 | 2963 | chuX | 0/0 | 100.0 | 100.0 | NP_756177 | (chuX) putative heme-binding protein ChuX [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00414 | 2963 | 3586 | chuY | 0/0 | 100.0 | 99.5 | NP_756178 | (chuY) ChuY [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00083 | 6631 | 7488 | entB | 0/0 | 100.0 | 99.3 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00083 | 3810 | 4997 | entC | 0/0 | 100.0 | 99.5 | NP_752611 | (entC) isochorismate synthase 1 [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00083 | 5007 | 6617 | entE | 0/0 | 100.0 | 98.8 | NP_752612 | (entE) 23-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00247 | 1443 | 5296 | entF | 0/0 | 99.3 | 98.6 | NP_752604 | (entF) enterobactin synthase multienzyme complex component ATP-dependent [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00083 | 1423 | 2673 | entS | 0/0 | 100.0 | 97.9 | NP_752609 | (entS) enterobactin exporter iron-regulated [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00062 | 2793 | 7043 | fdeC | 0/0 | 100.0 | 99.2 | YP_002390132 | (fdeC) adhesin FdeC [FdeC (VF0506)] [Escherichia coli O45:K1:H7 str. S88] |
| contig00655 | 125 | 2365 | fepA | 0/0 | 100.0 | 99.5 | NP_752600 | (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00083 | 2677 | 3633 | fepB | 0/0 | 100.0 | 99.4 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00603 | 1232 | 2047 | fepC | 0/0 | 100.0 | 99.0 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00083 | 308 | 1324 | fepD | 0/0 | 100.0 | 98.2 | NP_752608 | (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00247 | 23 | 1225 | fes | 0/0 | 100.0 | 99.7 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00377 | 3142 | 3747 | fimA | 0/0 | 100.0 | 91.1 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01154 | 183 | 775 | fimB | 0/0 | 98.3 | 99.8 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00377 | 1776 | 2501 | fimC | 0/0 | 100.0 | 99.2 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00554 | 1514 | 2047 | fimF | 0/0 | 100.0 | 98.9 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00554 | 998 | 1501 | fimG | 0/0 | 100.0 | 99.2 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00554 | 76 | 987 | fimH | 0/0 | 100.0 | 99.7 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00377 | 2538 | 3077 | fimI | 0/0 | 100.0 | 99.3 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00622 | 519 | 2369 | gspD | 1/15 | 100.0 | 94.7 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00451 | 2025 | 2480 | gspG | 0/0 | 100.0 | 95.6 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00451 | 1458 | 1988 | gspH | 0/0 | 100.0 | 94.9 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00451 | 1090 | 1461 | gspI | 0/0 | 100.0 | 91.4 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00451 | 488 | 1057 | gspJ | 0/0 | 100.0 | 94.6 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00741 | 542 | 1402 | gspL | 0/0 | 100.0 | 95.5 | YP_404608 | (gspL) general secretion pathway protein L [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00741 | 5 | 426 | gspM | 0/0 | 99.8 | 93.6 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00317 | 1668 | 3038 | ibeA | 2/2 | 99.9 | 98.5 | AAF98391 | (ibeA) invasion protein IbeA [Ibes (VF0237)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00082 | 2448 | 4124 | kpsD | 0/0 | 100.0 | 99.2 | AAA21682 | (kpsD) KpsD [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00681 | 606 | 1382 | kpsM | 0/0 | 100.0 | 95.2 | AAA24046 | (kpsM) KpsM [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00941 | 15 | 1055 | ompA | 0/0 | 100.0 | 99.6 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00152 | 2749 | 3502 | yagV/ecpE | 0/0 | 99.7 | 98.4 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00152 | 1182 | 2825 | yagW/ecpD | 0/0 | 100.0 | 99.2 | NP_286007 | (yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00452 | 1532 | 2200 | yagY/ecpB | 0/0 | 100.0 | 98.1 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00452 | 888 | 1475 | yagZ/ecpA | 0/0 | 100.0 | 98.3 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00515 | 1215 | 2018 | ybtT | 0/0 | 100.0 | 99.6 | NP_405469 | (ybtT) yersiniabactin biosynthetic protein YbtT [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00515 | 2015 | 3115 | ybtU | 0/0 | 100.0 | 99.6 | NP_405470 | (ybtU) yersiniabactin biosynthetic protein YbtU [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00607 | 380 | 1660 | ybtX | 0/0 | 100.0 | 99.7 | NP_405476 | (ybtX) putative signal transducer [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00452 | 224 | 814 | ykgK/ecpR | 0/0 | 100.0 | 99.3 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00758 | 1 | 1380 | aslA | 1/1 | 96.6 | 92.9 | AAG10151 | (aslA) putative arylsulfatase [AslA (VF0238)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00931 | 439 | 1395 | fepB | 0/0 | 100.0 | 97.5 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00311 | 898 | 2100 | fes | 0/0 | 100.0 | 96.7 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00884 | 690 | 1295 | fimA | 0/0 | 100.0 | 92.4 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00906 | 692 | 1294 | fimB | 0/0 | 100.0 | 98.0 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00426 | 1508 | 2041 | fimF | 0/0 | 100.0 | 97.0 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00426 | 992 | 1495 | fimG | 0/0 | 100.0 | 98.2 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00426 | 70 | 981 | fimH | 0/0 | 100.0 | 97.7 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00884 | 86 | 625 | fimI | 0/0 | 100.0 | 98.5 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00076 | 177 | 2027 | gspD | 1/15 | 100.0 | 97.1 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00076 | 2027 | 3520 | gspE | 0/0 | 100.0 | 96.5 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00775 | 154 | 609 | gspG | 0/0 | 100.0 | 95.0 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00775 | 646 | 1176 | gspH | 0/0 | 100.0 | 95.5 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00775 | 1173 | 1544 | gspI | 0/0 | 100.0 | 95.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00928 | 1 | 823 | gspL | 0/0 | 95.6 | 97.0 | YP_404608 | (gspL) general secretion pathway protein L [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00928 | 939 | 1361 | gspM | 0/0 | 100.0 | 97.9 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00304 | 1164 | 2204 | ompA | 0/0 | 100.0 | 98.1 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig01129 | 4 | 757 | yagV/ecpE | 0/0 | 99.7 | 97.1 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00100 | 734 | 1402 | yagY/ecpB | 0/0 | 100.0 | 98.1 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00100 | 89 | 676 | yagZ/ecpA | 0/0 | 100.0 | 99.2 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00795 | 41 | 1469 | aslA | 1/1 | 100.0 | 94.0 | AAG10151 | (aslA) putative arylsulfatase [AslA (VF0238)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00355 | 891 | 2228 | chuW | 0/0 | 100.0 | 96.3 | NP_756176 | (chuW) Putative oxygen independent coproporphyrinogen III oxidase [Chu (VF0227)] [Escherichia coli CFT073] |
| contig01641 | 26 | 775 | espY1 | 1/3 | 99.6 | 95.6 | NP_285753 | (espY1) Type III secretion system effector EspY1 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig00728 | 684 | 1499 | fepC | 0/0 | 100.0 | 96.9 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00558 | 991 | 2183 | fes | 0/0 | 99.2 | 96.7 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00019 | 6099 | 6704 | fimA | 0/0 | 100.0 | 96.9 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00019 | 4733 | 5458 | fimC | 0/0 | 100.0 | 98.3 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00019 | 2030 | 4666 | fimD | 0/0 | 100.0 | 98.6 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00019 | 1490 | 2023 | fimF | 0/0 | 100.0 | 96.4 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00019 | 974 | 1477 | fimG | 0/0 | 100.0 | 98.0 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00019 | 52 | 963 | fimH | 0/0 | 100.0 | 97.4 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00019 | 5495 | 6034 | fimI | 0/0 | 100.0 | 98.5 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00591 | 278 | 2112 | gspD | 1/15 | 99.1 | 97.5 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00854 | 189 | 1637 | gspE | 0/0 | 97.0 | 97.8 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00138 | 3396 | 3851 | gspG | 0/0 | 100.0 | 96.7 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00138 | 2829 | 3359 | gspH | 0/0 | 100.0 | 97.0 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00138 | 2461 | 2832 | gspI | 0/0 | 100.0 | 94.9 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00138 | 1859 | 2428 | gspJ | 0/0 | 100.0 | 97.2 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00138 | 885 | 1862 | gspK | 0/0 | 100.0 | 96.3 | YP_404607 | (gspK) general secretion pathway protein K [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01914 | 325 | 726 | gspM | 0/0 | 95.0 | 95.8 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00491 | 1639 | 2334 | shuV | 0/0 | 90.3 | 98.8 | YP_405013 | (shuV) ATP-binding component of hemin transport system [Shu (VF0256)] [Shigella dysenteriae Sd197] |
| contig00355 | 2241 | 2735 | shuX | 0/0 | 100.0 | 98.2 | YP_405016 | (shuX) shu locus protein ShuX [Shu (VF0256)] [Shigella dysenteriae Sd197] |
| contig01176 | 337 | 1092 | yagV/ecpE | 0/0 | 100.0 | 98.3 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig01169 | 326 | 994 | yagY/ecpB | 0/0 | 100.0 | 98.1 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig01496 | 80 | 670 | ykgK/ecpR | 0/0 | 100.0 | 97.6 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig01102 | 917 | 1313 | agg3B | 0/0 | 90.0 | 99.8 | AAM88297 | (agg3B) invasin protein [AAFs (VF0214)] [Escherichia coli 55989] |
| contig01774 | 551 | 667 | astA | 0/0 | 100.0 | 100.0 | BAA94855 | (astA) heat-stable enterotoxin 1 [EAST1 (VF0216)] [Escherichia coli O44:H18 042] |
| contig00143 | 1183 | 1929 | entA | 0/0 | 100.0 | 95.0 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00143 | 326 | 1183 | entB | 0/0 | 100.0 | 97.4 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00494 | 243 | 1430 | entC | 0/0 | 100.0 | 97.6 | NP_752611 | (entC) isochorismate synthase 1 [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00773 | 241 | 1491 | entS | 0/0 | 100.0 | 95.6 | NP_752609 | (entS) enterobactin exporter iron-regulated [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00408 | 845 | 1660 | fepC | 0/0 | 100.0 | 97.1 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00951 | 185 | 1015 | gspC | 0/0 | 100.0 | 94.6 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00008 | 4919 | 6412 | gspE | 0/0 | 100.0 | 96.5 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00008 | 3720 | 4919 | gspF | 0/0 | 100.0 | 96.3 | YP_404602 | (gspF) general secretion pathway protein F [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00008 | 3224 | 3679 | gspG | 0/0 | 100.0 | 95.6 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00008 | 2657 | 3187 | gspH | 0/0 | 100.0 | 95.7 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00008 | 2289 | 2660 | gspI | 0/0 | 100.0 | 94.6 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00008 | 1687 | 2256 | gspJ | 0/0 | 100.0 | 96.3 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00008 | 713 | 1690 | gspK | 0/0 | 100.0 | 96.4 | YP_404607 | (gspK) general secretion pathway protein K [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig02408 | 93 | 480 | gspM | 0/0 | 91.7 | 93.8 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00409 | 826 | 1773 | iucB | 0/0 | 100.0 | 99.8 | NP_755501 | (iucB) aerobactin siderophore biosynthesis protein IucB [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig01249 | 221 | 974 | yagV/ecpE | 0/0 | 99.7 | 96.8 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00071 | 894 | 3419 | yagX/ecpC | 0/0 | 100.0 | 98.7 | NP_286008 | (yagX/ecpC) E. coli common pilus usher EcpC [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00071 | 200 | 868 | yagY/ecpB | 0/0 | 100.0 | 98.2 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig01551 | 34 | 937 | ybtA | 0/0 | 94.2 | 99.7 | NP_405473 | (ybtA) transcriptional regulator YbtA [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00307 | 530 | 2332 | ybtQ | 0/0 | 100.0 | 99.8 | NP_405475 | (ybtQ) inner membrane ABC-transporter YbtQ [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00248 | 1616 | 2920 | ybtS | 0/0 | 100.0 | 99.6 | NP_405477 | (ybtS) salicylate synthase Irp9 [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00842 | 524 | 1602 | ybtU | 0/0 | 98.0 | 99.7 | NP_405470 | (ybtU) yersiniabactin biosynthetic protein YbtU [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00563 | 180 | 1607 | aslA | 2/2 | 99.9 | 96.3 | AAG10151 | (aslA) putative arylsulfatase [AslA (VF0238)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00102 | 1283 | 2311 | chuS | 0/0 | 100.0 | 97.7 | NP_756169 | (chuS) heme oxygenase ChuS [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00277 | 1672 | 2466 | chuV | 0/0 | 99.2 | 99.5 | NP_756180 | (chuV) ATP-binding hydrophilic protein ChuV [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00720 | 731 | 1225 | chuX | 0/0 | 100.0 | 97.4 | NP_756177 | (chuX) putative heme-binding protein ChuX [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00076 | 1833 | 3020 | entC | 0/0 | 100.0 | 97.5 | NP_752611 | (entC) isochorismate synthase 1 [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00076 | 700 | 1656 | fepB | 0/0 | 100.0 | 98.1 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00431 | 759 | 1574 | fepC | 0/0 | 100.0 | 97.3 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00861 | 115 | 570 | gspG | 0/0 | 100.0 | 94.5 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00861 | 607 | 1137 | gspH | 0/0 | 100.0 | 94.0 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00861 | 1134 | 1479 | gspI | 0/0 | 93.0 | 91.3 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00910 | 333 | 1310 | gspK | 0/0 | 100.0 | 96.1 | YP_404607 | (gspK) general secretion pathway protein K [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00571 | 1 | 1713 | iucA | 0/0 | 96.1 | 99.9 | NP_709454 | (iucA) aerobactin synthesis protein IucA [Aerobactin (VF0123)] [Shigella flexneri 2a str. 301] |
| contig00267 | 500 | 1837 | iucD | 0/0 | 100.0 | 99.8 | NP_709457 | (iucD) aerobactin synthesis protein IucC lysine 6-monooxygenase [Aerobactin (VF0123)] [Shigella flexneri 2a str. 301] |
| contig00087 | 1 | 1560 | kpsD | 0/0 | 93.0 | 99.0 | AAA21682 | (kpsD) KpsD [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00527 | 683 | 1459 | kpsM | 0/0 | 100.0 | 99.7 | AAA24046 | (kpsM) KpsM [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00527 | 27 | 686 | kpsT | 0/0 | 100.0 | 100.0 | AAA24047 | (kpsT) KpsT [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00868 | 3 | 1055 | ompA | 1/12 | 100.0 | 95.3 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00017 | 338 | 2860 | papC | 0/0 | 100.0 | 99.7 | NP_755465 | (papC) usher protein PapC [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00017 | 3060 | 3665 | papD | 0/0 | 100.0 | 99.7 | NP_755464 | (papD) chaperone protein PapD [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00017 | 4838 | 5377 | papE | 2/6 | 99.4 | 93.5 | NP_755460 | (papE) P pilus minor subunit PapE [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00017 | 5422 | 5955 | papF | 1/3 | 100.0 | 94.0 | NP_755459 | (papF) P pilus minor subunit PapF [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00856 | 508 | 1486 | papG | 0/0 | 96.8 | 99.2 | NP_755458 | (papG) P pilus tip adhesin PapG [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00017 | 3702 | 4283 | papJ | 0/0 | 100.0 | 97.9 | NP_755463 | (papJ) P pilus assembly protein PapJ [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00017 | 4290 | 4829 | papK | 0/0 | 100.0 | 99.3 | NP_755461 | (papK) P pilus minor subunit PapK [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00009 | 5505 | 6643 | senB | 0/0 | 99.9 | 99.7 | YP_406304 | (senB) enterotoxin [ShET2 (VF0258)] [Shigella flexneri 2a str. 301] |
| contig01458 | 221 | 974 | yagV/ecpE | 0/0 | 99.7 | 97.6 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00173 | 382 | 1050 | yagY/ecpB | 0/0 | 100.0 | 98.8 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00773 | 659 | 1564 | ybtA | 0/0 | 94.4 | 99.7 | NP_405473 | (ybtA) transcriptional regulator YbtA [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig01894 | 3 | 553 | ykgK/ecpR | 0/0 | 93.2 | 99.8 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00085 | 10279 | 11025 | entA | 0/0 | 100.0 | 95.0 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00085 | 9422 | 10279 | entB | 0/0 | 100.0 | 97.8 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00085 | 6601 | 7788 | entC | 0/0 | 100.0 | 97.9 | NP_752611 | (entC) isochorismate synthase 1 [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00085 | 7798 | 9408 | entE | 0/0 | 100.0 | 95.9 | NP_752612 | (entE) 23-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00205 | 3936 | 7789 | entF | 0/0 | 99.3 | 95.4 | NP_752604 | (entF) enterobactin synthase multienzyme complex component ATP-dependent [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00085 | 4214 | 5464 | entS | 0/0 | 100.0 | 95.6 | NP_752609 | (entS) enterobactin exporter iron-regulated [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00038 | 1157 | 3025 | espL1 | 2/30 | 98.4 | 95.3 | NP_288154 | (espL1) Type III secretion system effector espL1 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig00016 | 9064 | 13289 | fdeC | 1/3 | 99.4 | 92.4 | YP_002390132 | (fdeC) adhesin FdeC [FdeC (VF0506)] [Escherichia coli O45:K1:H7 str. S88] |
| contig00205 | 33 | 2273 | fepA | 0/0 | 100.0 | 96.9 | NP_752600 | (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00085 | 5468 | 6424 | fepB | 0/0 | 100.0 | 97.4 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00085 | 1298 | 2113 | fepC | 0/0 | 100.0 | 97.1 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00085 | 3099 | 4115 | fepD | 0/0 | 100.0 | 95.8 | NP_752608 | (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00085 | 2110 | 3102 | fepG | 0/0 | 100.0 | 94.6 | NP_752607 | (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00205 | 2516 | 3718 | fes | 0/0 | 100.0 | 96.8 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00697 | 1 | 603 | fimA | 1/1 | 99.5 | 90.6 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00699 | 220 | 822 | fimB | 0/0 | 100.0 | 98.0 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00284 | 4731 | 5456 | fimC | 0/0 | 100.0 | 97.9 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00284 | 2028 | 4664 | fimD | 0/0 | 100.0 | 98.7 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00284 | 1488 | 2021 | fimF | 0/0 | 100.0 | 96.4 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00284 | 972 | 1475 | fimG | 0/0 | 100.0 | 97.6 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00284 | 50 | 961 | fimH | 0/0 | 100.0 | 97.7 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00104 | 9605 | 10435 | gspC | 0/0 | 100.0 | 95.1 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00104 | 7515 | 9365 | gspD | 1/15 | 100.0 | 97.2 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00104 | 6022 | 7515 | gspE | 0/0 | 100.0 | 96.5 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00104 | 4823 | 6022 | gspF | 0/0 | 100.0 | 96.2 | YP_404602 | (gspF) general secretion pathway protein F [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00104 | 4327 | 4782 | gspG | 0/0 | 100.0 | 95.4 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00104 | 3760 | 4290 | gspH | 0/0 | 100.0 | 96.0 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00104 | 3392 | 3763 | gspI | 0/0 | 100.0 | 95.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00104 | 2790 | 3359 | gspJ | 0/0 | 100.0 | 97.2 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00104 | 1816 | 2793 | gspK | 0/0 | 100.0 | 97.5 | YP_404607 | (gspK) general secretion pathway protein K [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00104 | 641 | 1501 | gspL | 0/0 | 100.0 | 97.6 | YP_404608 | (gspL) general secretion pathway protein L [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00104 | 103 | 525 | gspM | 0/0 | 100.0 | 93.8 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00041 | 5511 | 6551 | ompA | 0/0 | 100.0 | 98.1 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00016 | 22395 | 23148 | yagV/ecpE | 0/0 | 99.7 | 96.8 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00016 | 20828 | 22471 | yagW/ecpD | 0/0 | 100.0 | 98.6 | NP_286007 | (yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00016 | 18313 | 20838 | yagX/ecpC | 0/0 | 100.0 | 98.7 | NP_286008 | (yagX/ecpC) E. coli common pilus usher EcpC [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00016 | 17619 | 18287 | yagY/ecpB | 0/0 | 100.0 | 98.7 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00016 | 16974 | 17561 | yagZ/ecpA | 0/0 | 100.0 | 99.3 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00016 | 16309 | 16899 | ykgK/ecpR | 0/0 | 100.0 | 97.6 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00144 | 3019 | 3765 | entA | 0/0 | 100.0 | 95.7 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00144 | 2162 | 3019 | entB | 0/0 | 100.0 | 98.0 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00144 | 538 | 2148 | entE | 0/0 | 100.0 | 95.5 | NP_752612 | (entE) 23-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00267 | 133 | 702 | espY2 | 0/0 | 100.0 | 93.3 | NP_285765 | (espY2) Type III secretion system effector EspY2 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig00446 | 1178 | 2194 | fepD | 0/0 | 100.0 | 96.2 | NP_752608 | (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00446 | 2191 | 3149 | fepG | 0/0 | 96.6 | 93.8 | NP_752607 | (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01087 | 791 | 1362 | fimB | 0/0 | 94.9 | 97.5 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00215 | 2055 | 4691 | fimD | 0/0 | 100.0 | 97.7 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01470 | 39 | 635 | fimE | 0/0 | 100.0 | 98.8 | NP_757240 | (fimE) Type 1 fimbriae Regulatory protein fimE [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00215 | 1515 | 2048 | fimF | 0/0 | 100.0 | 96.6 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00215 | 999 | 1502 | fimG | 0/0 | 100.0 | 97.4 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00215 | 77 | 988 | fimH | 0/0 | 100.0 | 97.5 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00751 | 675 | 1214 | fimI | 0/0 | 100.0 | 98.3 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00190 | 951 | 2801 | gspD | 1/15 | 100.0 | 96.1 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00190 | 2801 | 4294 | gspE | 0/0 | 100.0 | 96.9 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00351 | 2897 | 3352 | gspG | 0/0 | 100.0 | 95.0 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00351 | 2330 | 2860 | gspH | 0/0 | 100.0 | 95.5 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00351 | 1962 | 2333 | gspI | 0/0 | 100.0 | 95.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00351 | 1360 | 1929 | gspJ | 0/0 | 100.0 | 96.5 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00351 | 386 | 1363 | gspK | 0/0 | 100.0 | 96.9 | YP_404607 | (gspK) general secretion pathway protein K [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00202 | 822 | 1244 | gspM | 0/0 | 100.0 | 98.3 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00148 | 768 | 1715 | iucB | 0/0 | 100.0 | 99.8 | NP_709455 | (iucB) aerobactin synthesis protein IucB [Aerobactin (VF0123)] [Shigella flexneri 2a str. 301] |
| contig00148 | 1715 | 3457 | iucC | 0/0 | 100.0 | 99.7 | NP_709456 | (iucC) aerobactin synthesis protein IucC [Aerobactin (VF0123)] [Shigella flexneri 2a str. 301] |
| contig00148 | 3454 | 4791 | iucD | 0/0 | 100.0 | 99.5 | NP_755499 | (iucD) L-lysine 6-monooxygenase IucD [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig00041 | 3577 | 4617 | ompA | 0/0 | 100.0 | 98.1 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00195 | 119 | 4237 | pic | 0/0 | 100.0 | 100.0 | YP_006098864 | (pic) Pic serine protease precursor autotransporter [Pic (VF0218)] [Escherichia coli O44:H18 042] |
| contig00127 | 3678 | 4431 | yagV/ecpE | 0/0 | 99.7 | 97.1 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00127 | 2111 | 3754 | yagW/ecpD | 0/0 | 100.0 | 99.0 | NP_286007 | (yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig01325 | 165 | 752 | yagZ/ecpA | 0/0 | 100.0 | 99.2 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00219 | 2862 | 3821 | ybtA | 0/0 | 100.0 | 99.5 | NP_405473 | (ybtA) transcriptional regulator YbtA [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00219 | 893 | 2695 | ybtP | 0/0 | 100.0 | 99.6 | NP_405474 | (ybtP) lipoprotein inner membrane ABC-transporter [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00299 | 1353 | 2657 | ybtS | 0/0 | 100.0 | 99.8 | NP_405477 | (ybtS) salicylate synthase Irp9 [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00405 | 536 | 1339 | ybtT | 0/0 | 100.0 | 99.6 | NP_405469 | (ybtT) yersiniabactin biosynthetic protein YbtT [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00405 | 1336 | 2436 | ybtU | 0/0 | 100.0 | 99.9 | NP_405470 | (ybtU) yersiniabactin biosynthetic protein YbtU [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00299 | 2685 | 3965 | ybtX | 0/0 | 100.0 | 99.7 | NP_405476 | (ybtX) putative signal transducer [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00903 | 81 | 1509 | aslA | 1/1 | 100.0 | 97.2 | AAG10151 | (aslA) putative arylsulfatase [AslA (VF0238)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00133 | 1290 | 2318 | chuS | 0/0 | 100.0 | 96.2 | NP_756169 | (chuS) heme oxygenase ChuS [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00159 | 2421 | 3413 | chuU | 0/0 | 100.0 | 98.6 | NP_756179 | (chuU) heme permease protein ChuU [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00159 | 1654 | 2454 | chuV | 0/0 | 100.0 | 98.9 | NP_756180 | (chuV) ATP-binding hydrophilic protein ChuV [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00159 | 3462 | 4085 | chuY | 0/0 | 100.0 | 97.0 | NP_756178 | (chuY) ChuY [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00561 | 103 | 849 | entA | 0/0 | 100.0 | 96.0 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00314 | 1 | 1147 | entC | 0/0 | 96.5 | 96.8 | NP_752611 | (entC) isochorismate synthase 1 [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00314 | 1157 | 2767 | entE | 0/0 | 100.0 | 96.6 | NP_752612 | (entE) 23-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00263 | 1124 | 2374 | entS | 0/0 | 100.0 | 95.8 | NP_752609 | (entS) enterobactin exporter iron-regulated [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00263 | 164 | 1120 | fepB | 0/0 | 100.0 | 97.9 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00263 | 2473 | 3489 | fepD | 0/0 | 100.0 | 96.2 | NP_752608 | (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01787 | 247 | 818 | fimB | 0/0 | 94.9 | 98.1 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00815 | 202 | 927 | fimC | 0/0 | 100.0 | 98.5 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00250 | 1280 | 3698 | fimD | 0/0 | 91.7 | 98.5 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00250 | 740 | 1273 | fimF | 0/0 | 100.0 | 97.4 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00250 | 224 | 727 | fimG | 0/0 | 100.0 | 98.0 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00815 | 964 | 1503 | fimI | 0/0 | 100.0 | 98.3 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00618 | 737 | 1596 | gspL | 1/1 | 99.9 | 94.7 | YP_404608 | (gspL) general secretion pathway protein L [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00618 | 200 | 621 | gspM | 0/0 | 99.8 | 92.4 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00123 | 2792 | 3955 | iroB | 0/0 | 100.0 | 98.7 | NP_753168 | (iroB) glucosyltransferase IroB [Salmochelin (IA013)] [Escherichia coli CFT073] |
| contig00164 | 960 | 1916 | iroE | 0/0 | 100.0 | 99.5 | NP_753165 | (iroE) esterase [Salmochelin (IA013)] [Escherichia coli CFT073] |
| contig00164 | 1961 | 4138 | iroN | 0/0 | 100.0 | 98.9 | NP_753164 | (iroN) salmochelin receptor IroN [IroN (VF0230)] [Escherichia coli CFT073] |
| contig00286 | 975 | 1922 | iucB | 0/0 | 100.0 | 100.0 | NP_755501 | (iucB) aerobactin siderophore biosynthesis protein IucB [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig00286 | 1922 | 3504 | iucC | 0/0 | 90.8 | 100.0 | NP_755500 | (iucC) aerobactin siderophore biosynthesis protein IucC [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig00219 | 86 | 1423 | iucD | 0/0 | 100.0 | 100.0 | NP_755499 | (iucD) L-lysine 6-monooxygenase IucD [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig00219 | 1345 | 3624 | iutA | 0/0 | 100.0 | 100.0 | NP_755498 | (iutA) ferric aerobactin receptor precusor IutA [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig00097 | 2448 | 4124 | kpsD | 0/0 | 100.0 | 98.8 | AAA21682 | (kpsD) KpsD [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00927 | 572 | 1348 | kpsM | 0/0 | 100.0 | 91.1 | AAA24046 | (kpsM) KpsM [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00138 | 3117 | 4157 | ompA | 0/0 | 100.0 | 99.1 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00218 | 179 | 2701 | papC | 0/0 | 100.0 | 99.7 | NP_755465 | (papC) usher protein PapC [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00218 | 2901 | 3506 | papD | 0/0 | 100.0 | 100.0 | NP_755464 | (papD) chaperone protein PapD [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig01112 | 46 | 1056 | papG | 0/0 | 100.0 | 98.8 | NP_755458 | (papG) P pilus tip adhesin PapG [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00386 | 63 | 296 | papI | 0/0 | 100.0 | 99.1 | NP_755468 | (papI) regulatory protein PapI [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig01942 | 197 | 715 | papK | 0/0 | 96.1 | 99.2 | NP_755461 | (papK) P pilus minor subunit PapK [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig01767 | 196 | 747 | papX | 0/0 | 100.0 | 100.0 | NP_755457 | (papX) PapX protein regulates flagellum synthesis to repress motility [P fimbriae (CVF425)] [Escherichia coli CFT073] |
| contig00133 | 2367 | 4349 | shuA | 0/0 | 100.0 | 98.1 | YP_405019 | (shuA) outer membrane heme/hemoglobin receptor ShuA [Shu (VF0256)] [Shigella dysenteriae Sd197] |
| contig00351 | 87 | 840 | yagV/ecpE | 0/0 | 99.7 | 97.2 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00328 | 1356 | 2024 | yagY/ecpB | 0/0 | 100.0 | 98.4 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00328 | 711 | 1298 | yagZ/ecpA | 0/0 | 100.0 | 98.8 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00153 | 733 | 2535 | ybtQ | 0/0 | 100.0 | 99.8 | NP_405475 | (ybtQ) inner membrane ABC-transporter YbtQ [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00476 | 963 | 1766 | ybtT | 0/0 | 100.0 | 99.8 | NP_405469 | (ybtT) yersiniabactin biosynthetic protein YbtT [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00153 | 2528 | 3808 | ybtX | 0/0 | 100.0 | 99.6 | NP_405476 | (ybtX) putative signal transducer [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00328 | 46 | 636 | ykgK/ecpR | 0/0 | 100.0 | 99.0 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00416 | 470 | 1216 | entA | 0/0 | 100.0 | 96.0 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00275 | 271 | 2511 | fepA | 0/0 | 100.0 | 96.8 | NP_752600 | (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00662 | 493 | 1308 | fepC | 0/0 | 100.0 | 97.4 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00915 | 434 | 1346 | fimH | 1/1 | 100.0 | 96.9 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00325 | 1579 | 2370 | gspC | 0/0 | 95.3 | 95.2 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00166 | 211 | 2061 | gspD | 1/15 | 100.0 | 97.1 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00775 | 400 | 930 | gspH | 0/0 | 100.0 | 95.5 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00775 | 927 | 1298 | gspI | 0/0 | 100.0 | 95.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00649 | 71 | 931 | gspL | 0/0 | 100.0 | 97.1 | YP_404608 | (gspL) general secretion pathway protein L [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00132 | 821 | 2563 | iucC | 0/0 | 100.0 | 98.1 | NP_755500 | (iucC) aerobactin siderophore biosynthesis protein IucC [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig00482 | 581 | 1621 | ompA | 0/0 | 100.0 | 98.1 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00151 | 2534 | 3067 | papF | 1/3 | 100.0 | 94.0 | NP_755459 | (papF) P pilus minor subunit PapF [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig02450 | 206 | 439 | papI | 0/0 | 100.0 | 95.3 | NP_755468 | (papI) regulatory protein PapI [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig01902 | 91 | 759 | yagY/ecpB | 0/0 | 100.0 | 98.1 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00085 | 3574 | 4246 | entA | 0/0 | 90.1 | 95.2 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00085 | 2717 | 3574 | entB | 0/0 | 100.0 | 98.1 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00085 | 1 | 1083 | entC | 0/0 | 91.2 | 97.7 | NP_752611 | (entC) isochorismate synthase 1 [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00085 | 1093 | 2703 | entE | 0/0 | 100.0 | 95.5 | NP_752612 | (entE) 23-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00218 | 681 | 1697 | fepD | 0/0 | 100.0 | 96.1 | NP_752608 | (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00218 | 1694 | 2686 | fepG | 0/0 | 100.0 | 94.1 | NP_752607 | (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01999 | 64 | 669 | fimA | 0/0 | 100.0 | 90.1 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00173 | 1488 | 2021 | fimF | 0/0 | 100.0 | 97.4 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00173 | 972 | 1475 | fimG | 0/0 | 100.0 | 98.4 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00173 | 50 | 961 | fimH | 0/0 | 100.0 | 97.3 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00775 | 398 | 1355 | iroE | 1/1 | 100.0 | 98.8 | NP_753165 | (iroE) esterase [Salmochelin (IA013)] [Escherichia coli CFT073] |
| contig00009 | 748 | 1695 | iucB | 0/0 | 100.0 | 99.9 | NP_709455 | (iucB) aerobactin synthesis protein IucB [Aerobactin (VF0123)] [Shigella flexneri 2a str. 301] |
| contig00009 | 1695 | 3437 | iucC | 0/0 | 100.0 | 99.9 | NP_709456 | (iucC) aerobactin synthesis protein IucC [Aerobactin (VF0123)] [Shigella flexneri 2a str. 301] |
| contig00009 | 3434 | 4771 | iucD | 0/0 | 100.0 | 99.8 | NP_709457 | (iucD) aerobactin synthesis protein IucC lysine 6-monooxygenase [Aerobactin (VF0123)] [Shigella flexneri 2a str. 301] |
| contig00009 | 4693 | 6972 | iutA | 0/0 | 100.0 | 99.5 | NP_755498 | (iutA) ferric aerobactin receptor precusor IutA [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig01264 | 158 | 1210 | ompA | 1/12 | 100.0 | 94.2 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00713 | 2 | 1627 | yagW/ecpD | 0/0 | 98.9 | 99.1 | NP_286007 | (yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig01155 | 32 | 700 | yagY/ecpB | 0/0 | 100.0 | 98.1 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig02000 | 115 | 702 | yagZ/ecpA | 0/0 | 100.0 | 99.2 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00137 | 777 | 1769 | fepG | 0/0 | 100 | 94.1 | NP_752607 | (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00952 | 305 | 1030 | fimC | 0/0 | 100.0 | 98.6 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00027 | 1082 | 1615 | fimF | 0/0 | 100.0 | 97.8 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00027 | 566 | 1069 | fimG | 0/0 | 100.0 | 97.8 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00299 | 445 | 1782 | iucD | 0/0 | 100.0 | 99.9 | NP_709457 | (iucD) aerobactin synthesis protein IucC lysine 6-monooxygenase [Aerobactin (VF0123)] [Shigella flexneri 2a str. 301] |
| contig00373 | 221 | 974 | yagV/ecpE | 0/0 | 99.7 | 97.1 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00372 | 510 | 1790 | ybtX | 0/0 | 100.0 | 99.4 | NP_405476 | (ybtX) putative signal transducer [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00379 | 2508 | 3936 | aslA | 1/1 | 100.0 | 98.2 | AAG10151 | (aslA) putative arylsulfatase [AslA (VF0238)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00262 | 3105 | 5051 | chuA | 0/0 | 100.0 | 99.5 | NP_756170 | (chuA) Outer membrane heme/hemoglobin receptor ChuA [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00262 | 2028 | 3056 | chuS | 0/0 | 100.0 | 99.0 | NP_756169 | (chuS) heme oxygenase ChuS [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00643 | 545 | 1537 | chuT | 0/0 | 100.0 | 99.8 | NP_756175 | (chuT) periplasmic heme-binding protein ChuT [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00193 | 3614 | 4606 | chuU | 0/0 | 100.0 | 99.2 | NP_756179 | (chuU) heme permease protein ChuU [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00193 | 2847 | 3647 | chuV | 0/0 | 100.0 | 99.8 | NP_756180 | (chuV) ATP-binding hydrophilic protein ChuV [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00193 | 5278 | 5772 | chuX | 0/0 | 100.0 | 100.0 | NP_756177 | (chuX) putative heme-binding protein ChuX [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00193 | 4655 | 5278 | chuY | 0/0 | 100.0 | 98.4 | NP_756178 | (chuY) ChuY [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00720 | 382 | 609 | daaF | 0/0 | 100.0 | 100.0 | AAA23662 | (daaF) DaaF protein [F1845 fimbrial adhesin (AI016)] [Escherichia coli str. C1845] |
| contig00722 | 1706 | 2149 | draD | 0/0 | 100.0 | 99.8 | AAK16478 | (draD) DraD periplasmic protein [Dr adhesins (VF0223)] [Escherichia coli O75:K5:H- str. IH11128] |
| contig00722 | 408 | 967 | draE2 | 1/1 | 99.6 | 99.6 | AAB65153 | (draE2) Dr-II structural adhesin precursor [Afa/Dr family (VF0212)] [Escherichia coli EC7372] |
| contig00722 | 1154 | 1327 | draP | 0/0 | 100.0 | 99.4 | AAK16479 | (draP) DraP [Dr adhesins (VF0223)] [Escherichia coli O75:K5:H- str. IH11128] |
| contig00076 | 8289 | 9035 | entA | 0/0 | 100.0 | 98.1 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00512 | 1009 | 2619 | entE | 0/0 | 100.0 | 99.1 | NP_752612 | (entE) 23-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00393 | 1233 | 2483 | entS | 0/0 | 100.0 | 98.2 | NP_752609 | (entS) enterobactin exporter iron-regulated [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00690 | 127 | 2367 | fepA | 0/0 | 100.0 | 98.8 | NP_752600 | (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00393 | 273 | 1229 | fepB | 0/0 | 100.0 | 99.7 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00639 | 1325 | 2140 | fepC | 0/0 | 100.0 | 99.1 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00393 | 2582 | 3598 | fepD | 0/0 | 100.0 | 97.8 | NP_752608 | (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00149 | 6124 | 6728 | fimA | 1/1 | 99.8 | 90.8 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00655 | 1007 | 1609 | fimB | 0/0 | 100.0 | 97.8 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00149 | 4758 | 5483 | fimC | 0/0 | 100.0 | 98.6 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00149 | 2055 | 4691 | fimD | 0/0 | 100.0 | 98.9 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00149 | 1515 | 2048 | fimF | 0/0 | 100.0 | 99.1 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00149 | 999 | 1502 | fimG | 0/0 | 100.0 | 98.2 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00149 | 77 | 988 | fimH | 0/0 | 100.0 | 97.6 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00149 | 5520 | 6059 | fimI | 0/0 | 100.0 | 98.5 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00668 | 710 | 2519 | gspD | 1/15 | 97.8 | 96.2 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00265 | 1233 | 2432 | gspF | 0/0 | 100.0 | 94.2 | YP_404602 | (gspF) general secretion pathway protein F [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00265 | 2473 | 2928 | gspG | 0/0 | 100.0 | 95.8 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00265 | 2965 | 3495 | gspH | 0/0 | 100.0 | 96.6 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00265 | 3492 | 3863 | gspI | 0/0 | 100.0 | 94.6 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00265 | 3896 | 4465 | gspJ | 0/0 | 100.0 | 94.4 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00675 | 551 | 1411 | gspL | 0/0 | 100.0 | 93.3 | YP_404608 | (gspL) general secretion pathway protein L [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00675 | 1527 | 1936 | gspM | 0/0 | 96.9 | 93.4 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00100 | 4056 | 5732 | kpsD | 0/0 | 100.0 | 99.5 | AAA21682 | (kpsD) KpsD [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00792 | 431 | 1207 | kpsM | 0/0 | 100.0 | 91.1 | AAA24046 | (kpsM) KpsM [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00036 | 1771 | 2823 | ompA | 1/12 | 100.0 | 95.8 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig01432 | 261 | 574 | papB | 1/1 | 99.7 | 98.4 | (papB) regulatory protein PapB [P fimbriae (VF0220)] [Escherichia coli CFT073] | |
| contig01348 | 282 | 515 | papI | 0/0 | 100.0 | 94.9 | NP_755468 | (papI) regulatory protein PapI [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig01080 | 254 | 805 | papX | 0/0 | 100.0 | 97.6 | NP_755457 | (papX) PapX protein regulates flagellum synthesis to repress motility [P fimbriae (CVF425)] [Escherichia coli CFT073] |
| contig00111 | 6081 | 7219 | senB | 0/0 | 99.9 | 99.7 | YP_406304 | (senB) enterotoxin [ShET2 (VF0258)] [Shigella flexneri 2a str. 301] |
| contig00282 | 2077 | 2830 | yagV/ecpE | 0/0 | 99.7 | 98.0 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00282 | 510 | 2153 | yagW/ecpD | 0/0 | 100.0 | 99.1 | NP_286007 | (yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00132 | 4797 | 5465 | yagY/ecpB | 0/0 | 100.0 | 98.1 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00132 | 4153 | 4740 | yagZ/ecpA | 0/0 | 100.0 | 98.3 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig01009 | 336 | 1295 | ybtA | 0/0 | 100.0 | 99.5 | NP_405473 | (ybtA) transcriptional regulator YbtA [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00225 | 3250 | 5052 | ybtQ | 0/0 | 100.0 | 99.6 | NP_405475 | (ybtQ) inner membrane ABC-transporter YbtQ [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00225 | 645 | 1949 | ybtS | 0/0 | 100.0 | 99.8 | NP_405477 | (ybtS) salicylate synthase Irp9 [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00329 | 3381 | 4184 | ybtT | 0/0 | 100.0 | 99.5 | NP_405469 | (ybtT) yersiniabactin biosynthetic protein YbtT [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00329 | 2284 | 3384 | ybtU | 0/0 | 100.0 | 99.6 | NP_405470 | (ybtU) yersiniabactin biosynthetic protein YbtU [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00225 | 1977 | 3257 | ybtX | 0/0 | 100.0 | 99.5 | NP_405476 | (ybtX) putative signal transducer [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00132 | 3488 | 4078 | ykgK/ecpR | 0/0 | 100.0 | 99.5 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00009 | 4506 | 4622 | astA | 0/0 | 100.0 | 99.1 | BAA94855 | (astA) heat-stable enterotoxin 1 [EAST1 (VF0216)] [Escherichia coli O44:H18 042] |
| contig00742 | 341 | 1087 | entA | 0/0 | 100.0 | 95.7 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00542 | 3 | 1304 | espX1 | 0/0 | 91.6 | 93.0 | NP_285716 | (espX1) Type III secretion system effector EspX1 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig01182 | 1 | 951 | fepB | 0/0 | 99.4 | 97.5 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00313 | 996 | 1598 | fimB | 0/0 | 100.0 | 97.7 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00126 | 167 | 700 | fimF | 0/0 | 100.0 | 96.8 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00814 | 285 | 1196 | fimH | 0/0 | 100.0 | 97.4 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00102 | 1 | 1254 | ybtS | 0/0 | 96.1 | 99.7 | NP_405477 | (ybtS) salicylate synthase Irp9 [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00102 | 1282 | 2527 | ybtX | 0/0 | 97.3 | 99.4 | NP_405476 | (ybtX) putative signal transducer [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00076 | 1638 | 2420 | chuV | 0/0 | 97.8 | 98.2 | NP_756180 | (chuV) ATP-binding hydrophilic protein ChuV [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00441 | 204 | 1385 | fes | 0/0 | 98.2 | 96.5 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00324 | 851 | 1456 | fimA | 0/0 | 100.0 | 92.2 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01983 | 13 | 615 | fimB | 0/0 | 100.0 | 99.5 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01193 | 12 | 515 | fimG | 0/0 | 100.0 | 98.0 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00324 | 247 | 786 | fimI | 0/0 | 100.0 | 99.4 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01866 | 1 | 549 | gspJ | 0/0 | 96.3 | 94.2 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig03019 | 2 | 423 | gspM | 0/0 | 99.8 | 92.9 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00002 | 1 | 1747 | iucA | 0/0 | 97.7 | 94.1 | NP_755502 | (iucA) aerobactin siderophore biosynthesis protein IucD [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig00002 | 1748 | 2695 | iucB | 0/0 | 100.0 | 95.6 | NP_755501 | (iucB) aerobactin siderophore biosynthesis protein IucB [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig00002 | 2695 | 4437 | iucC | 0/0 | 100.0 | 96.0 | NP_755500 | (iucC) aerobactin siderophore biosynthesis protein IucC [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig00724 | 158 | 1134 | ompA | 1/12 | 92.7 | 95.0 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00436 | 157 | 1149 | shuT | 0/0 | 100.0 | 98.1 | YP_405017 | (shuT) periplasmic binding protein ShuT [Shu (VF0256)] [Shigella dysenteriae Sd197] |
| contig00382 | 176 | 929 | yagV/ecpE | 0/0 | 99.7 | 97.0 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig01444 | 115 | 861 | entA | 0/0 | 100 | 95.5 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig02230 | 18 | 614 | fimE | 0/0 | 100 | 99.2 | NP_757240 | (fimE) Type 1 fimbriae Regulatory protein fimE [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00717 | 912 | 1445 | fimF | 0/0 | 100 | 98.1 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00717 | 396 | 899 | fimG | 0/0 | 100 | 97.8 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00647 | 417 | 956 | fimI | 0/0 | 100 | 99.1 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00642 | 663 | 1493 | gspC | 0/0 | 100 | 95.1 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00300 | 1064 | 1519 | gspG | 0/0 | 100 | 95.8 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00300 | 1556 | 2086 | gspH | 0/0 | 100 | 96.0 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01153 | 393 | 962 | gspJ | 0/0 | 100 | 97.2 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00613 | 436 | 858 | gspM | 0/0 | 100 | 94.1 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00232 | 558 | 1226 | yagY/ecpB | 0/0 | 100 | 98.2 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig01676 | 186 | 776 | ykgK/ecpR | 0/0 | 100 | 97.5 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00822 | 226 | 1654 | aslA | 1/1 | 100.0 | 93.6 | AAG10151 | (aslA) putative arylsulfatase [AslA (VF0238)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig01052 | 243 | 1430 | entC | 0/0 | 100.0 | 97.9 | NP_752611 | (entC) isochorismate synthase 1 [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01015 | 1 | 1505 | entE | 0/0 | 93.4 | 95.3 | NP_752612 | (entE) 23-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00627 | 125 | 2365 | fepA | 0/0 | 100.0 | 96.7 | NP_752600 | (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01175 | 235 | 1191 | fepB | 0/0 | 100.0 | 97.4 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00619 | 1318 | 2133 | fepC | 0/0 | 100.0 | 97.2 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00619 | 329 | 1321 | fepG | 0/0 | 100.0 | 94.1 | NP_752607 | (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00328 | 1 | 1191 | fes | 0/0 | 99.0 | 96.6 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig01253 | 428 | 1033 | fimA | 0/0 | 100.0 | 90.8 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01421 | 252 | 854 | fimB | 0/0 | 100.0 | 97.8 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00382 | 2520 | 3245 | fimC | 0/0 | 100.0 | 98.3 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00382 | 1 | 2453 | fimD | 0/0 | 93.0 | 98.2 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01386 | 124 | 720 | fimE | 0/0 | 100.0 | 99.0 | NP_757240 | (fimE) Type 1 fimbriae Regulatory protein fimE [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00729 | 1488 | 2021 | fimF | 0/0 | 100.0 | 97.4 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00729 | 972 | 1475 | fimG | 0/0 | 100.0 | 98.4 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00729 | 50 | 961 | fimH | 0/0 | 100.0 | 97.4 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00629 | 1015 | 2055 | ompA | 0/0 | 100.0 | 98.1 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00505 | 1198 | 1802 | fimA | 1/1 | 99.8 | 91.1 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00787 | 864 | 1466 | fimB | 0/0 | 100.0 | 97.8 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01204 | 215 | 940 | fimC | 0/0 | 100.0 | 98.6 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00089 | 1642 | 4077 | fimD | 0/0 | 92.4 | 98.8 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00505 | 178 | 774 | fimE | 0/0 | 100.0 | 99.2 | NP_757240 | (fimE) Type 1 fimbriae Regulatory protein fimE [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00089 | 1101 | 1634 | fimF | 0/0 | 100.0 | 97.8 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00089 | 585 | 1088 | fimG | 0/0 | 100.0 | 98.4 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00131 | 1166 | 2659 | gspE | 0/0 | 100.0 | 95.6 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00439 | 142 | 1119 | gspK | 0/0 | 100.0 | 96.9 | YP_404607 | (gspK) general secretion pathway protein K [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01240 | 716 | 1137 | gspM | 0/0 | 99.8 | 92.9 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00252 | 1 | 2066 | hlyB | 0/0 | 97.3 | 99.5 | NP_755448 | (hlyB) Hemolysin B [Hemolysin (VF0225)] [Escherichia coli CFT073] |
| contig00637 | 468 | 1805 | iucD | 0/0 | 100.0 | 100.0 | NP_755499 | (iucD) L-lysine 6-monooxygenase IucD [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig00668 | 295 | 1071 | kpsM | 0/0 | 100.0 | 95.2 | AAA24046 | (kpsM) KpsM [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00306 | 15 | 1067 | ompA | 1/12 | 100.0 | 94.3 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig02167 | 255 | 567 | papB | 0/0 | 99.4 | 99.7 | (papB) regulatory protein PapB [P fimbriae (VF0220)] [Escherichia coli CFT073] | |
| contig00011 | 644 | 3166 | papC | 0/0 | 100.0 | 99.8 | NP_755465 | (papC) usher protein PapC [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00011 | 3366 | 3971 | papD | 0/0 | 100.0 | 100.0 | NP_755464 | (papD) chaperone protein PapD [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00011 | 5734 | 6264 | papF | 0/0 | 100.0 | 99.2 | NP_755459 | (papF) P pilus minor subunit PapF [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00011 | 6308 | 7318 | papG | 0/0 | 100.0 | 99.4 | NP_755458 | (papG) P pilus tip adhesin PapG [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00011 | 10 | 597 | papH | 0/0 | 100.0 | 98.6 | NP_755466 | (papH) P pilus termination subunit PapH [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00011 | 4008 | 4589 | papJ | 0/0 | 100.0 | 98.3 | NP_755463 | (papJ) P pilus assembly protein PapJ [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00011 | 4596 | 5135 | papK | 0/0 | 100.0 | 99.4 | NP_755461 | (papK) P pilus minor subunit PapK [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig01881 | 196 | 747 | papX | 0/0 | 100.0 | 100.0 | NP_755457 | (papX) PapX protein regulates flagellum synthesis to repress motility [P fimbriae (CVF425)] [Escherichia coli CFT073] |
| contig00027 | 692 | 4591 | sat | 0/0 | 100.0 | 100.0 | NP_755494 | (sat) Aecreted auto transpoter toxin [Sat (VF0231)] [Escherichia coli CFT073] |
| contig00018 | 4535 | 5673 | senB | 0/0 | 99.9 | 99.7 | YP_406304 | (senB) enterotoxin [ShET2 (VF0258)] [Shigella flexneri 2a str. 301] |
| contig01241 | 268 | 1021 | yagV/ecpE | 0/0 | 99.7 | 96.8 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00046 | 3537 | 4124 | yagZ/ecpA | 0/0 | 100.0 | 99.3 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig01487 | 1 | 1023 | ybtU | 0/0 | 92.9 | 99.4 | NP_405470 | (ybtU) yersiniabactin biosynthetic protein YbtU [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00412 | 1061 | 2269 | ybtX | 0/0 | 94.4 | 97.4 | NP_405476 | (ybtX) putative signal transducer [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00046 | 2872 | 3462 | ykgK/ecpR | 0/0 | 100.0 | 97.6 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00394 | 1571 | 2317 | entA | 0/0 | 100.0 | 95.0 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00394 | 714 | 1571 | entB | 0/0 | 100.0 | 97.8 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00534 | 254 | 1441 | entC | 0/0 | 100.0 | 97.5 | NP_752611 | (entC) isochorismate synthase 1 [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00059 | 3826 | 7679 | entF | 0/0 | 99.3 | 95.6 | NP_752604 | (entF) enterobactin synthase multienzyme complex component ATP-dependent [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00059 | 11969 | 13219 | entS | 0/0 | 100.0 | 95.5 | NP_752609 | (entS) enterobactin exporter iron-regulated [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00035 | 5891 | 7759 | espL1 | 2/30 | 98.4 | 95.3 | NP_288154 | (espL1) Type III secretion system effector espL1 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig00046 | 12749 | 14041 | espX5 | 0/0 | 100.0 | 95.5 | NP_290699 | (espX5) Type III secretion system effector EspX5 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig00059 | 1 | 2163 | fepA | 0/0 | 96.5 | 97.1 | NP_752600 | (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00059 | 13223 | 14179 | fepB | 0/0 | 100.0 | 97.3 | NP_752610 | (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00059 | 9053 | 9868 | fepC | 0/0 | 100.0 | 97.1 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00059 | 10854 | 11870 | fepD | 0/0 | 100.0 | 95.8 | NP_752608 | (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00059 | 9865 | 10857 | fepG | 0/0 | 100.0 | 94.8 | NP_752607 | (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00059 | 2406 | 3608 | fes | 0/0 | 100.0 | 96.7 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00348 | 3818 | 4422 | fimA | 1/1 | 99.8 | 90.6 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00584 | 1002 | 1604 | fimB | 0/0 | 100.0 | 97.8 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00348 | 2452 | 3177 | fimC | 0/0 | 100.0 | 98.5 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00348 | 1 | 2385 | fimD | 0/0 | 90.4 | 98.5 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00752 | 15 | 611 | fimE | 0/0 | 100.0 | 99.2 | NP_757240 | (fimE) Type 1 fimbriae Regulatory protein fimE [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00535 | 1500 | 2033 | fimF | 0/0 | 100.0 | 98.1 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00535 | 984 | 1487 | fimG | 0/0 | 100.0 | 97.8 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00535 | 62 | 973 | fimH | 0/0 | 100.0 | 97.5 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00348 | 3214 | 3753 | fimI | 0/0 | 100.0 | 99.1 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00095 | 9605 | 10435 | gspC | 0/0 | 100.0 | 95.0 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00095 | 7515 | 9365 | gspD | 1/15 | 100.0 | 97.0 | YP_404600 | (gspD) general secretion pathway protein D [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00095 | 6022 | 7515 | gspE | 0/0 | 100.0 | 96.0 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00095 | 4823 | 6022 | gspF | 0/0 | 100.0 | 96.3 | YP_404602 | (gspF) general secretion pathway protein F [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00095 | 4327 | 4782 | gspG | 0/0 | 100.0 | 96.0 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00095 | 3760 | 4290 | gspH | 0/0 | 100.0 | 95.5 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00095 | 3392 | 3763 | gspI | 0/0 | 100.0 | 94.1 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00095 | 2790 | 3359 | gspJ | 0/0 | 100.0 | 97.2 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00095 | 1816 | 2793 | gspK | 0/0 | 100.0 | 97.3 | YP_404607 | (gspK) general secretion pathway protein K [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00095 | 641 | 1501 | gspL | 0/0 | 100.0 | 97.3 | YP_404608 | (gspL) general secretion pathway protein L [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00095 | 103 | 525 | gspM | 0/0 | 100.0 | 97.2 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00050 | 1576 | 2616 | ompA | 0/0 | 100.0 | 98.1 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00262 | 2424 | 3177 | yagV/ecpE | 0/0 | 99.7 | 96.8 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00262 | 857 | 2500 | yagW/ecpD | 0/0 | 100.0 | 98.7 | NP_286007 | (yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00145 | 1290 | 1958 | yagY/ecpB | 0/0 | 100.0 | 98.5 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00145 | 2016 | 2599 | yagZ/ecpA | 0/0 | 99.3 | 99.1 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00145 | 2677 | 3267 | ykgK/ecpR | 0/0 | 100.0 | 97.6 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00768 | 67 | 1494 | aslA | 2/2 | 99.9 | 96.3 | AAG10151 | (aslA) putative arylsulfatase [AslA (VF0238)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00126 | 2670 | 3662 | chuU | 0/0 | 100.0 | 99.2 | NP_756179 | (chuU) heme permease protein ChuU [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00126 | 154 | 1491 | chuW | 0/0 | 100.0 | 98.6 | NP_756176 | (chuW) Putative oxygen independent coproporphyrinogen III oxidase [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00126 | 1504 | 1998 | chuX | 0/0 | 100.0 | 97.4 | NP_756177 | (chuX) putative heme-binding protein ChuX [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00126 | 1998 | 2621 | chuY | 0/0 | 100.0 | 98.6 | NP_756178 | (chuY) ChuY [Chu (VF0227)] [Escherichia coli CFT073] |
| contig01198 | 123 | 1277 | entC | 0/0 | 97.2 | 97.4 | NP_752611 | (entC) isochorismate synthase 1 [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00471 | 1 | 1583 | entE | 0/0 | 98.3 | 98.3 | NP_752612 | (entE) 23-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00553 | 834 | 1403 | espY2 | 0/0 | 100.0 | 94.2 | NP_285765 | (espY2) Type III secretion system effector EspY2 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig00181 | 793 | 1608 | fepC | 0/0 | 100.0 | 97.3 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00181 | 1605 | 2597 | fepG | 0/0 | 100.0 | 94.5 | NP_752607 | (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00917 | 258 | 1460 | fes | 0/0 | 100.0 | 97.4 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00355 | 1174 | 2588 | gspE | 0/0 | 94.7 | 94.3 | YP_404601 | (gspE) general secretion pathway protein E [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00288 | 1655 | 2830 | gspF | 0/0 | 98.0 | 94.3 | YP_404602 | (gspF) general secretion pathway protein F [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00288 | 1159 | 1614 | gspG | 0/0 | 100.0 | 94.5 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00288 | 592 | 1122 | gspH | 0/0 | 100.0 | 94.0 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00288 | 224 | 595 | gspI | 0/0 | 100.0 | 91.9 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01201 | 181 | 1158 | gspK | 0/0 | 100.0 | 96.1 | YP_404607 | (gspK) general secretion pathway protein K [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00641 | 110 | 970 | gspL | 0/0 | 100.0 | 94.9 | YP_404608 | (gspL) general secretion pathway protein L [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00641 | 1086 | 1507 | gspM | 0/0 | 99.8 | 93.6 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00472 | 1 | 2084 | iutA | 0/0 | 94.9 | 99.9 | NP_709458 | (iutA) aerobactin receptor IutA [Aerobactin (VF0123)] [Shigella flexneri 2a str. 301] |
| contig00945 | 323 | 1099 | kpsM | 0/0 | 100.0 | 99.7 | AAA24046 | (kpsM) KpsM [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00011 | 260 | 2782 | papC | 0/0 | 100.0 | 99.7 | NP_755465 | (papC) usher protein PapC [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00011 | 2982 | 3587 | papD | 0/0 | 100.0 | 99.7 | NP_755464 | (papD) chaperone protein PapD [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00011 | 4760 | 5299 | papE | 2/6 | 99.4 | 93.5 | NP_755460 | (papE) P pilus minor subunit PapE [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00011 | 5344 | 5877 | papF | 1/3 | 100.0 | 94.0 | NP_755459 | (papF) P pilus minor subunit PapF [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00011 | 5921 | 6931 | papG | 0/0 | 100.0 | 99.0 | NP_755458 | (papG) P pilus tip adhesin PapG [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00011 | 3624 | 4205 | papJ | 0/0 | 100.0 | 97.9 | NP_755463 | (papJ) P pilus assembly protein PapJ [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00011 | 4212 | 4751 | papK | 0/0 | 100.0 | 99.3 | NP_755461 | (papK) P pilus minor subunit PapK [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00979 | 355 | 906 | papX | 0/0 | 100.0 | 97.8 | NP_755457 | (papX) PapX protein regulates flagellum synthesis to repress motility [P fimbriae (CVF425)] [Escherichia coli CFT073] |
| contig00127 | 2331 | 3469 | senB | 0/0 | 99.9 | 99.7 | YP_406304 | (senB) enterotoxin [ShET2 (VF0258)] [Shigella flexneri 2a str. 301] |
| contig00231 | 1338 | 2006 | yagY/ecpB | 0/0 | 100.0 | 98.8 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00231 | 693 | 1280 | yagZ/ecpA | 0/0 | 100.0 | 99.2 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00040 | 4148 | 4951 | ybtT | 0/0 | 100.0 | 99.5 | NP_405469 | (ybtT) yersiniabactin biosynthetic protein YbtT [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00040 | 3051 | 4151 | ybtU | 0/0 | 100.0 | 99.6 | NP_405470 | (ybtU) yersiniabactin biosynthetic protein YbtU [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00682 | 410 | 1690 | ybtX | 0/0 | 100.0 | 99.6 | NP_405476 | (ybtX) putative signal transducer [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00231 | 28 | 618 | ykgK/ecpR | 0/0 | 100.0 | 99.7 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig02589 | 186 | 374 | afaF-VII | 0/0 | 100 | 98.4 | AAK16195 | (afaF-VII) AfaF-VII [Afimbrial adhesin AfaE-VIII (AI015)] [Escherichia coli str. 239 KH 89] |
| contig00475 | 115 | 861 | entA | 0/0 | 100 | 95.7 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01584 | 342 | 875 | fimF | 0/0 | 100 | 97.9 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00132 | 1032 | 1487 | gspG | 0/0 | 100 | 95.0 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00132 | 1524 | 2054 | gspH | 0/0 | 100 | 95.3 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00132 | 2051 | 2422 | gspI | 0/0 | 100 | 95.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00132 | 2455 | 3024 | gspJ | 0/0 | 100 | 96.7 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00387 | 514 | 1851 | iucD | 0/0 | 100 | 100.0 | NP_755499 | (iucD) L-lysine 6-monooxygenase IucD [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig00303 | 537 | 1577 | ompA | 0/0 | 100 | 98.1 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig01105 | 853 | 1122 | stx1B | 0/0 | 100 | 100.0 | NP_288672 | (stx1B) shiga-like toxin 1 subunit B encoded within prophage CP-933V [Stx (VF0206)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00437 | 285 | 1313 | chuS | 0/0 | 100.0 | 96.9 | NP_756169 | (chuS) heme oxygenase ChuS [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00284 | 219 | 995 | eltA | 0/0 | 100.0 | 98.8 | AAA24685 | (eltA) heat-labile enterotoxin A prepeptide (from human) [Heat-labile toxin (LT) (VF0210)] [Escherichia coli] |
| contig00284 | 992 | 1366 | eltB | 0/0 | 100.0 | 99.2 | AAA98064 | (eltB) enterotoxin subunit B (from human) [Heat-labile toxin (LT) (VF0210)] [Escherichia coli] |
| contig00436 | 1605 | 2291 | entA | 0/0 | 92.0 | 94.0 | NP_752614 | (entA) 23-dihydro-23-dihydroxybenzoate dehydrogenase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00436 | 748 | 1603 | entB | 0/0 | 99.8 | 95.4 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00979 | 57 | 1244 | entC | 0/0 | 100.0 | 95.8 | NP_752611 | (entC) isochorismate synthase 1 [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00006 | 1 | 4169 | fdeC | 1/3 | 98.1 | 92.0 | YP_002390132 | (fdeC) adhesin FdeC [FdeC (VF0506)] [Escherichia coli O45:K1:H7 str. S88] |
| contig00459 | 1112 | 1927 | fepC | 0/0 | 100.0 | 96.1 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00478 | 632 | 1648 | fepD | 0/0 | 100.0 | 96.5 | NP_752608 | (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00937 | 369 | 1486 | fes | 0/0 | 92.9 | 96.0 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig02014 | 188 | 732 | fimB | 0/0 | 90.4 | 96.9 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01335 | 299 | 1024 | fimC | 0/0 | 100.0 | 96.7 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01457 | 219 | 752 | fimF | 0/0 | 100.0 | 96.8 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00681 | 332 | 1162 | gspC | 0/0 | 100.0 | 94.6 | YP_404599 | (gspC) general secretion pathway protein C [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00922 | 30 | 560 | gspH | 0/0 | 100.0 | 94.5 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00922 | 557 | 928 | gspI | 0/0 | 100.0 | 92.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00922 | 961 | 1500 | gspJ | 0/0 | 94.7 | 94.3 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01426 | 142 | 560 | gspM | 0/0 | 99.0 | 93.1 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00240 | 1784 | 2824 | ompA | 0/0 | 100.0 | 98.8 | AAF37887 | (ompA) outer membrane protein A [OmpA (VF0236)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00735 | 400 | 1392 | shuT | 0/0 | 100.0 | 98.4 | YP_405017 | (shuT) periplasmic binding protein ShuT [Shu (VF0256)] [Shigella dysenteriae Sd197] |
| contig01417 | 305 | 1047 | shuV | 0/0 | 96.4 | 98.9 | YP_405013 | (shuV) ATP-binding component of hemin transport system [Shu (VF0256)] [Shigella dysenteriae Sd197] |
| contig01321 | 305 | 973 | yagY/ecpB | 0/0 | 100.0 | 97.8 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00342 | 678 | 2106 | aslA | 1/1 | 100.0 | 97.3 | AAG10151 | (aslA) putative arylsulfatase [AslA (VF0238)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00416 | 998 | 1813 | fepC | 0/0 | 100.0 | 96.7 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig01042 | 156 | 1285 | fes | 0/0 | 93.9 | 96.5 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00077 | 1497 | 2030 | fimF | 0/0 | 100.0 | 97.6 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00077 | 981 | 1484 | fimG | 0/0 | 100.0 | 98.0 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00077 | 59 | 970 | fimH | 0/0 | 100.0 | 97.3 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00227 | 331 | 1530 | gspF | 0/0 | 100.0 | 94.0 | YP_404602 | (gspF) general secretion pathway protein F [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00227 | 1571 | 2026 | gspG | 0/0 | 100.0 | 96.3 | YP_404603 | (gspG) general secretion pathway protein G [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00227 | 2063 | 2593 | gspH | 0/0 | 100.0 | 95.7 | YP_404604 | (gspH) general secretion pathway protein H [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00002 | 6001 | 6754 | yagV/ecpE | 0/0 | 99.7 | 97.0 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00002 | 4434 | 6077 | yagW/ecpD | 0/0 | 100.0 | 99.1 | NP_286007 | (yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00002 | 1919 | 4444 | yagX/ecpC | 0/0 | 100.0 | 99.0 | NP_286008 | (yagX/ecpC) E. coli common pilus usher EcpC [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00002 | 1225 | 1893 | yagY/ecpB | 0/0 | 100.0 | 99.0 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00002 | 584 | 1167 | yagZ/ecpA | 0/0 | 99.3 | 99.1 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00843 | 1 | 1365 | aslA | 1/1 | 95.5 | 97.4 | AAG10151 | (aslA) putative arylsulfatase [AslA (VF0238)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig00283 | 1046 | 2074 | chuS | 0/0 | 100.0 | 96.2 | NP_756169 | (chuS) heme oxygenase ChuS [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00065 | 3431 | 4423 | chuU | 0/0 | 100.0 | 98.6 | NP_756179 | (chuU) heme permease protein ChuU [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00065 | 915 | 2252 | chuW | 0/0 | 100.0 | 96.7 | NP_756176 | (chuW) Putative oxygen independent coproporphyrinogen III oxidase [Chu (VF0227)] [Escherichia coli CFT073] |
| contig00065 | 2759 | 3382 | chuY | 0/0 | 100.0 | 97.0 | NP_756178 | (chuY) ChuY [Chu (VF0227)] [Escherichia coli CFT073] |
| contig01490 | 509 | 736 | daaF | 0/0 | 100.0 | 98.7 | AAA23662 | (daaF) DaaF protein [F1845 fimbrial adhesin (AI016)] [Escherichia coli str. C1845] |
| contig02616 | 190 | 495 | draA | 0/0 | 100.0 | 100.0 | AAK16475 | (draA) cytoplamic protein DraA [Dr adhesins (VF0223)] [Escherichia coli O75:K5:H- str. IH11128] |
| contig00872 | 709 | 1453 | draB | 1/1 | 100.0 | 99.9 | AAK16476 | (draB) chaperone protein DraB [Dr adhesins (VF0223)] [Escherichia coli O75:K5:H- str. IH11128] |
| contig01310 | 299 | 472 | draP | 0/0 | 100.0 | 98.3 | AAK16479 | (draP) DraP [Dr adhesins (VF0223)] [Escherichia coli O75:K5:H- str. IH11128] |
| contig00133 | 1 | 3563 | entF | 0/0 | 91.8 | 95.7 | NP_752604 | (entF) enterobactin synthase multienzyme complex component ATP-dependent [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00156 | 815 | 2065 | entS | 0/0 | 100.0 | 95.8 | NP_752609 | (entS) enterobactin exporter iron-regulated [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00633 | 546 | 1361 | fepC | 0/0 | 100.0 | 96.8 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00156 | 2164 | 3180 | fepD | 0/0 | 100.0 | 96.2 | NP_752608 | (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00627 | 1 | 559 | fimA | 0/0 | 92.2 | 90.2 | NP_757241 | (fimA) Type-1 fimbrial protein A chain precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig01719 | 254 | 856 | fimB | 0/0 | 100.0 | 97.8 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00627 | 1200 | 1900 | fimC | 0/0 | 96.6 | 98.9 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00056 | 2049 | 4685 | fimD | 0/0 | 100.0 | 98.5 | NP_757244 | (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00056 | 1509 | 2042 | fimF | 0/0 | 100.0 | 96.6 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00056 | 993 | 1496 | fimG | 0/0 | 100.0 | 98.4 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00056 | 71 | 982 | fimH | 0/0 | 100.0 | 97.5 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00627 | 624 | 1163 | fimI | 0/0 | 100.0 | 98.5 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00983 | 619 | 990 | gspI | 0/0 | 100.0 | 92.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00983 | 17 | 586 | gspJ | 0/0 | 100.0 | 94.4 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig02492 | 200 | 588 | gspM | 0/0 | 92.0 | 93.3 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00060 | 905 | 2226 | iucD | 1/1 | 98.8 | 96.3 | NP_755499 | (iucD) L-lysine 6-monooxygenase IucD [Aerobactin (VF0229)] [Escherichia coli CFT073] |
| contig00931 | 540 | 1316 | kpsM | 0/0 | 100.0 | 94.7 | AAA24046 | (kpsM) KpsM [K1 capsule (VF0239)] [Escherichia coli O18:K1:H7 str. RS218] |
| contig01543 | 747 | 1031 | papB | 1/1 | 90.5 | 98.2 | (papB) regulatory protein PapB [P fimbriae (VF0220)] [Escherichia coli CFT073] | |
| contig02677 | 222 | 455 | papI | 0/0 | 100.0 | 94.9 | NP_755468 | (papI) regulatory protein PapI [P fimbriae (VF0220)] [Escherichia coli CFT073] |
| contig00065 | 1 | 895 | shuT | 0/0 | 90.1 | 98.2 | YP_405017 | (shuT) periplasmic binding protein ShuT [Shu (VF0256)] [Shigella dysenteriae Sd197] |
| contig00065 | 2265 | 2759 | shuX | 0/0 | 100.0 | 96.4 | YP_405016 | (shuX) shu locus protein ShuX [Shu (VF0256)] [Shigella dysenteriae Sd197] |
| contig00025 | 3022 | 3775 | yagV/ecpE | 0/0 | 99.7 | 97.2 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00025 | 1455 | 3098 | yagW/ecpD | 0/0 | 100.0 | 99.0 | NP_286007 | (yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00244 | 2114 | 2782 | yagY/ecpB | 0/0 | 100.0 | 98.4 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00244 | 1469 | 2056 | yagZ/ecpA | 0/0 | 100.0 | 98.8 | NP_286010 | (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00189 | 1388 | 2965 | ybtE | 0/0 | 100.0 | 99.9 | NP_405468 | (ybtE) yersiniabactin siderophore biosynthetic protein [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00189 | 581 | 1384 | ybtT | 0/0 | 100.0 | 99.2 | NP_405469 | (ybtT) yersiniabactin biosynthetic protein YbtT [Yersiniabactin (VF0136)] [Yersinia pestis CO92] |
| contig00244 | 804 | 1394 | ykgK/ecpR | 0/0 | 100.0 | 99.0 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Contig | Start | End | Gene | Gaps | Coverage | Identity | Accession | Product |
|---|---|---|---|---|---|---|---|---|
| contig00974 | 316 | 1173 | entB | 0/0 | 100.0 | 97.8 | NP_752613 | (entB) isochorismatase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00753 | 97 | 1347 | entS | 0/0 | 100.0 | 95.6 | NP_752609 | (entS) enterobactin exporter iron-regulated [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig00093 | 1084 | 2982 | espL1 | 0/0 | 100.0 | 97.6 | NP_288154 | (espL1) Type III secretion system effector espL1 [LEE encoded T3SS (SS020)] [Escherichia coli O157:H7 str. EDL933] |
| contig00468 | 1485 | 2300 | fepC | 0/0 | 100.0 | 97.3 | NP_752606 | (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00468 | 496 | 1488 | fepG | 0/0 | 100.0 | 94.0 | NP_752607 | (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228)] [Escherichia coli CFT073] |
| contig00550 | 931 | 2133 | fes | 0/0 | 100.0 | 96.8 | NP_752602 | (fes) enterobactin/ferric enterobactin esterase [enterobactin (IA019)] [Escherichia coli CFT073] |
| contig01098 | 744 | 1346 | fimB | 0/0 | 100.0 | 97.8 | NP_757239 | (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00242 | 1704 | 2429 | fimC | 0/0 | 100.0 | 98.3 | NP_757243 | (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00060 | 3858 | 4391 | fimF | 0/0 | 100.0 | 97.9 | NP_757245 | (fimF) FimF protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00060 | 3342 | 3845 | fimG | 0/0 | 100.0 | 98.2 | NP_757247 | (fimG) FimG protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00060 | 2420 | 3331 | fimH | 0/0 | 100.0 | 97.8 | NP_757248 | (fimH) FimH protein precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00242 | 2466 | 3005 | fimI | 0/0 | 100.0 | 99.1 | NP_757242 | (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221)] [Escherichia coli CFT073] |
| contig00965 | 151 | 522 | gspI | 0/0 | 100.0 | 95.2 | YP_404605 | (gspI) general secretion pathway protein I [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00965 | 555 | 1124 | gspJ | 0/0 | 100.0 | 97.4 | YP_404606 | (gspJ) general secretion pathway protein J [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig01628 | 222 | 644 | gspM | 0/0 | 100.0 | 94.1 | YP_404609 | (gspM) general secretion pathway protein M [T2SS (VF0333)] [Shigella dysenteriae Sd197] |
| contig00282 | 221 | 974 | yagV/ecpE | 0/0 | 99.7 | 96.8 | NP_286006 | (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00218 | 1 | 2322 | yagX/ecpC | 0/0 | 91.9 | 98.6 | NP_286008 | (yagX/ecpC) E. coli common pilus usher EcpC [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig01086 | 564 | 1232 | yagY/ecpB | 0/0 | 100.0 | 98.1 | NP_286009 | (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| contig00260 | 2553 | 3143 | ykgK/ecpR | 0/0 | 100.0 | 97.3 | NP_286011 | (ykgK/ecpR) regulator protein EcpR [ECP (VF0404)] [Escherichia coli O157:H7 str. EDL933] |
| Symbol | Meaning |
|---|---|
| ~ | novel full length allele similar to match |
| ? | partial match to known allele |
| - | allele missing |
| Scheme | ST | 1 | 2 | 3 | 4 | 5 | 6 | 7 | |
|---|---|---|---|---|---|---|---|---|---|
| Catt-BWE_048B | ecoli | - | adk(-) | fumC(1489?) | gyrB(14) | icd(16) | mdh(948?) | purA(8) | recA(14) |
| Catt-BWE_054A | ecoli | - | adk(18) | fumC(1238) | gyrB(764) | icd(1197?) | mdh(4) | purA(5) | recA(4) |
| Catt-BWE_113B | ecoli | - | adk(6) | fumC(6) | gyrB(3) | icd(1149?) | mdh(7) | purA(7) | recA(6) |
| Catt-HIM_031B | - | - | |||||||
| Catt-HIM_045B | ecoli | - | adk(6) | fumC(-) | gyrB(983?) | icd(1158?) | mdh(866?) | purA(2) | recA(779?) |
| Catt-HIM_048B | senterica | - | aroC(621) | dnaN(559) | hemD(496?) | hisD(764?) | purE(617) | sucA(281) | thrA(695) |
| Catt-HIM_068A | ecoli | - | adk(9) | fumC(65) | gyrB(5) | icd(1249?) | mdh(9) | purA(13) | recA(6) |
| Catt-HIM_073A | ecoli | - | adk(-) | fumC(1431?) | gyrB(3) | icd(1232?) | mdh(11) | purA(8) | recA(6) |
| Catt-HIM_082A1 | ecoli | - | adk(9) | fumC(-) | gyrB(5) | icd(1247?) | mdh(9) | purA(13) | recA(6) |
| Catt-KAT_009_A1 | ecoli | 10 | adk(10) | fumC(11) | gyrB(4) | icd(8) | mdh(8) | purA(8) | recA(2) |
| Catt-KAT_013A1 | ecoli | - | adk(1050?) | fumC(19) | gyrB(33) | icd(1232?) | mdh(11) | purA(8) | recA(6) |
| Catt-KAT_036B | - | - | |||||||
| Home-BWE_054A | ecoli | 2 | adk(5) | fumC(3) | gyrB(2) | icd(6) | mdh(5) | purA(5) | recA(4) |
| Home-HIM_031A | ecoli | - | adk(842?) | fumC(1518?) | gyrB(32) | icd(16) | mdh(11) | purA(8) | recA(14) |
| Home-HIM_032A | ecoli | - | adk(10) | fumC(1521?) | gyrB(5) | icd(364?) | mdh(949?) | purA(8) | recA(780?) |
| Home-HIM_045A | ecoli | - | adk(6) | fumC(4) | gyrB(14) | icd(1166?) | mdh(24) | purA(8) | recA(14) |
| Home-HIM_047B | ecloacae | - | dnaA(~93) | fusA(18) | gyrB(~276) | leuS(107) | pyrG(34) | rplB(110) | rpoB(29) |
| Home-HIM_048A | ecoli | - | adk(13) | fumC(888?) | gyrB(10) | icd(97) | mdh(17) | purA(94) | recA(93) |
| Home-HIM_068B | cfreundii | - | aspC(171) | clpX(193?) | fadD(112?) | mdh(172) | arcA(~114) | dnaG(84) | lysP(-) |
| Home-HIM_071A | ecoli | - | adk(351) | fumC(1467?) | gyrB(54) | icd(54) | mdh(1) | purA(35) | recA(151) |
| Home-HIM_072A | senterica | - | aroC(~622) | dnaN(559) | hemD(552) | hisD(765?) | purE(~690) | sucA(~580) | thrA(695) |
| Home-HIM_073B | ecoli | - | adk(27) | fumC(-) | gyrB(24) | icd(-) | mdh(26) | purA(168?) | recA(745?) |
| Home-HIM_075A | ecoli | - | adk(1081?) | fumC(579) | gyrB(3) | icd(16) | mdh(11) | purA(8) | recA(6) |
| Home-HIM_82A | ecoli | - | adk(10) | fumC(11) | gyrB(4) | icd(8) | mdh(949?) | purA(8) | recA(2) |
| Home-KAT_009A | ecoli | - | adk(21) | fumC(1394?) | gyrB(946?) | icd(6) | mdh(5) | purA(5) | recA(725?) |
| Home-KAT_013A | senterica | - | aroC(621) | dnaN(559) | hemD(~496) | hisD(-) | purE(617) | sucA(281?) | thrA(~633) |
| Home-KAT_023A | ecoli | 10 | adk(10) | fumC(11) | gyrB(4) | icd(8) | mdh(8) | purA(8) | recA(2) |
| Home-KAT_039B | ecoli | - | adk(-) | fumC(11) | gyrB(983?) | icd(1250?) | mdh(915?) | purA(8) | recA(2) |
| Hosp-BWE_048 | ecoli | - | adk(10) | fumC(1521?) | gyrB(979?) | icd(1250?) | mdh(923?) | purA(8) | recA(776?) |
| Hosp-BWE_054 | ecoli | - | adk(53) | fumC(40) | gyrB(945?) | icd(13) | mdh(36) | purA(28) | recA(29) |
| Hosp-BWE_076 | ecoli | - | adk(670?) | fumC(1487?) | gyrB(983?) | icd(-) | mdh(923?) | purA(8) | recA(2) |
| Hosp-BWE_106 | - | - | |||||||
| Hosp-HIM_031 | senterica | - | aroC(622?) | dnaN(559) | hemD(343?) | hisD(~763) | purE(~686) | sucA(~580) | thrA(~695) |
| Hosp-HIM_045 | senterica | - | aroC(621) | dnaN(559) | hemD(496) | hisD(764?) | purE(617) | sucA(281) | thrA(~695) |
| Hosp-HIM_048 | ecoli | - | adk(6) | fumC(4) | gyrB(983?) | icd(1149?) | mdh(24) | purA(8) | recA(14) |
| Hosp-HIM_068 | ecoli | - | adk(6) | fumC(23?) | gyrB(15) | icd(26) | mdh(9) | purA(8) | recA(7) |
| Hosp-HIM_071A | ecoli | - | adk(27) | fumC(32?) | gyrB(24) | icd(29) | mdh(944?) | purA(19) | recA(22) |
| Hosp-HIM_82 | ecoli | - | adk(10) | fumC(-) | gyrB(4) | icd(8) | mdh(775?) | purA(35) | recA(766?) |
| Hosp-KAT_009 | ecoli | - | adk(52) | fumC(403) | gyrB(76?) | icd(761?) | mdh(902?) | purA(40) | recA(278) |
| Hosp-KAT_013 | senterica | - | aroC(622?) | dnaN(559?) | hemD(496) | hisD(764?) | purE(~690) | sucA(281?) | thrA(695?) |
| Hosp-KAT_023 | cfreundii | - | aspC(69) | clpX(169?) | fadD(77) | mdh(175?) | arcA(~111) | dnaG(164?) | lysP(~101) |
| Hosp-KAT_039 | ecoli | - | adk(6) | fumC(6) | gyrB(33) | icd(1232?) | mdh(11) | purA(8) | recA(2) |
| Genes | Description | Number |
|---|---|---|
| Core genes | (99% <= strains <= 100%) | 0 |
| Soft core genes | (95% <= strains < 99%) | 27 |
| Shell genes | (15% <= strains < 95%) | 5645 |
| Cloud genes | (0% <= strains < 15%) | 17237 |
| Total genes | (0% <= strains <= 100%) | 22909 |